Results 111 to 120 of about 872,770 (359)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

Lynch Heads Into Final Year With High Approval Ratings, Concerns About Economy Remain 2/6/2012 [PDF]

open access: yes, 2012
Entering his last year in office, New Hampshire Governor John Lynch’s job approval rating remains very high. Economic problems continue to be the top concerns for Granite Staters, but have moderated somewhat in recent ...
Survey Center, UNH
core   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

Key Challenges in Economic Management of Pakistan

open access: yesLahore Journal of Economics
This paper points out that GDP growth is fundamentally on track although a little below the expected 7% target owing to commodity sector weaknesses. The rising trend in unemployment has been reversed over 2002-04. It is expected that longer trend growth
Taufiq A. Hussain
doaj  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Do Markets Care about Central Bank Governor Changes? Evidence from Emerging Markets [PDF]

open access: yes
Central bank governor changes in emerging markets may convey important signals about future monetary policy. Based on a new daily data set, this paper examines the reactions of foreign exchange markets, domestic stock market indices and sovereign bond ...
Axel Dreher, Christoph Moser
core  

Reflections on public service: An evening with Micheal and Kitty Dukakis [PDF]

open access: yes, 2017
Discussion with Massachusetts governor and 1988 candidate for President, Michael Dukakis, and his wife, Kitty Dukakis, reflect on lives devoted to public service and politicsBoston University Howard Thurman Center for Common ...
Boston University Howard Thurman Center for Common Ground
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

The Policy of the Russian State on the Governance of Nomadic Peoples in the First Half of the XIX Century (the Case Study of Kalmyks)

open access: yesOriental Studies, 2018
The article deals with the policy of the Russian state on the governance of Kalmyks in the first half of the XIXth century. After the departure of the most part of the Kalmyk people to the territory of Qing China, the status of its statehood was ...
M. .. Goryaev, A. .. Komandzhaev
doaj  

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