Results 101 to 110 of about 239,312 (339)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Opening address:

open access: yesScientific Annals of Economics and Business
The invitation to open this conference, which I most gladly accepted, is both an honour for me, on a personal level, and for the institution I represent.
Luís Máximo dos Santos
doaj   +1 more source

STATE DEBT: A CONCEPTUAL TREATMENT [PDF]

open access: yesEconomy and Sociology, 2014
Government debt (also known as public debt and national debt) is the debt owed by a central government. (In the U.S. and other federal states, "government debt" may also refer to the debt of a state or provincial government, municipal or local
Ion STURZU
doaj  

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

Key Issues in Managing Pakistan’s Economy Inaugural address

open access: yesLahore Journal of Economics
Pakistan was one of the few developing countries that had achieved an average growth rate of over 5 percent over a four decade period ending in 1990. Consequently, the incidence of poverty had declined from 40 percent to 18 percent by the end of 1980s ...
Ishrat Husain
doaj  

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

open access: yesMolecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini   +1 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Office of Lieutenant Governor

open access: yes, 2007
Updated irregularly; Began in 2002?; Title from home page (publisher's Web site, viewed Oct. 26, 2010).; Harvested from the web on 10/26/10This web site provides information about the Lieutenant Governor, news and photographs, the text of speeches and ...

core   +1 more source

Key Challenges in Economic Management of Pakistan

open access: yesLahore Journal of Economics
This paper points out that GDP growth is fundamentally on track although a little below the expected 7% target owing to commodity sector weaknesses. The rising trend in unemployment has been reversed over 2002-04. It is expected that longer trend growth
Taufiq A. Hussain
doaj  

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