Results 91 to 100 of about 239,312 (339)

Instrukce pro hornolužické zeměpanské úředníky v 16. století | Instructions for Upper Lusatian officials in the 16th century [PDF]

open access: yesHistorie - Otázky - Problémy, 2019
The author focuses on the creation of the monarchical administration in Upper Lusatia as one of the Lands of the Bohemian Crown, after the mid-16th century, when significant changes in this area were made.
Tomáš Velička
doaj  

Особенности деятельности Полтавского земства в период Первой мировой войны (1914 – 1916 гг.)

open access: yesТеорія і практика правознавства, 2016
Раскрыто особенности деятельности земства в условиях военного положения и стремления правительства Российской империи максимально эффективно использовать земства для военных нужд.
А. І. Козаченко
doaj   +1 more source

Executive Office of Governor; Office of Governor

open access: yes, 2007
Updated irregularly; Began in 2002?; Title from HTML header (publisher's Web site, viewed Oct. 26, 2010).; Harvested from the web on 10/26/10This web site is a source of information about the Governor, news, policies, executive orders, legislative ...

core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

The Voivodeship Governor’s Role in Health Safety

open access: yesStudia Iuridica Lublinensia, 2018
One of the voivodeship governor’s areas of public activities encompasses health safety. Being the element of this safety, health protection is the area requiring both responsible and efficient measures, as well as considerable financial means. One of the
M. Karpiuk, J. Kostrubiec
semanticscholar   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

The Crisis Goes On: How to Respond? [PDF]

open access: yesRomanian Journal of European Affairs, 2009
The world seems to suffer the first crisis of the globalization. Prior to this, individual country or regional experience has been accumulated on financial crisis, which taught policymakers how to design remedial policies, but there has not been a World ...
Eugen Dijmarescu
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

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