Results 81 to 90 of about 855,405 (260)

RETHINKING MACROECONOMY AND CENTRAL BANKING IN THE NEW NORMAL

open access: yesBuletin Ekonomi Moneter dan Perbankan, 2021
Perry Warjiyo
doaj   +1 more source

Shaheen Approval Steady 2/21/2002 [PDF]

open access: yes, 2002
Governor Jeanne Shaheen currently receives moderate job approval ratings from Granite Staters.
Survey Center, UNH
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Human Capital as the Instrument of Public Administration in the Sphere of Increasing the Competitiveness of the Regional Economy: Theoretical Aspects

open access: yesУправленческое консультирование, 2018
This paper considers the current problem of human capital and its place in increasing the competitiveness of the regional economy. The aim of the article is to study the impact of human capital on improving the competitiveness of the regional economy ...
Dmitry Valerievich Gonin
doaj  

Hassan Widens Lead Over Havenstein In NH Governor\u27s Race, GOP Likely To Win Both Houses In Legislature 10/29/14 [PDF]

open access: yes, 2014
Incumbent Maggie Hassan has widened her lead over Republican challenger Walt Havenstein in the race for New Hampshire governor.
Survey Center, UNH
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

Inkle and Yarico; or, Love in a Cave. An Interesting Tale. [PDF]

open access: yes
Narcissa Curry and Thomas Inkle are informed in the beginning of the story that they are engaged to be married. In England, Thomas is happy to hear of his impending marriage, while Narcissa mourns in Barbadoes because of her love of Captain Campley ...
Wilkinson, Sarah Scudgell
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Instrukce pro hornolužické zeměpanské úředníky v 16. století | Instructions for Upper Lusatian officials in the 16th century [PDF]

open access: yesHistorie - Otázky - Problémy, 2019
The author focuses on the creation of the monarchical administration in Upper Lusatia as one of the Lands of the Bohemian Crown, after the mid-16th century, when significant changes in this area were made.
Tomáš Velička
doaj  

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