Results 61 to 70 of about 29,049 (260)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

open access: yesFEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani   +3 more
wiley   +1 more source

RETHINKING MACROECONOMY AND CENTRAL BANKING IN THE NEW NORMAL

open access: yesBuletin Ekonomi Moneter dan Perbankan, 2021
Perry Warjiyo
doaj   +1 more source

The Governor of Saratov stolnik Danila Varfolomeevich Khitrovo (1659–1660) [PDF]

open access: yesИзвестия Саратовского университета. Новая серия: История. Международные отношения
The article for the first time presents the biography of the Saratov governor Danila Varfolomeevich Khitrovo, as well as brief information about his ancestors, the Bolkhov landowners. D. V.
Rabinovich, Yakov N.
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

The Crisis Goes On: How to Respond? [PDF]

open access: yesRomanian Journal of European Affairs, 2009
The world seems to suffer the first crisis of the globalization. Prior to this, individual country or regional experience has been accumulated on financial crisis, which taught policymakers how to design remedial policies, but there has not been a World ...
Eugen Dijmarescu
doaj  

Structure‐forward targeting of claudins with synthetic binders

open access: yesFEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

open access: yesFEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas   +4 more
wiley   +1 more source

Effects of vector preferential settling in the dynamics of a plant virus model with latent periods

open access: yesHeliyon
Insect vectors transmit many plant viruses of agricultural importance. In most cases, these viruses manipulate their vectors' behavior and movement leading to vector settling and feeding preferences that influence virus spread.
Kimben M. Gonzales, Juancho A. Collera
doaj   +1 more source

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