Results 181 to 190 of about 2,763 (200)

Virulence of Paracoccidioides brasiliensis and gp43 expression in isolates bearing known PbGP43 genotype.

Microbes and Infection, 2005
Paracoccidioides brasiliensis is the dimorphic fungus responsible for human paracoccidioidomycosis (PCM). We previously observed that P. brasiliensis isolates bearing highly polymorphic PbGP43 of genotype A (Pb2, Pb3 and Pb4) were phylogenetically distant from the others.
K. C. Carvalho, L. Ganiko, W. L. Batista, F. Morais, E. R. Marques, G. Goldman, M. Franco, R. Puccia   +7 more
semanticscholar   +3 more sources

Genetic insertions and diversification of the PolB-type DNA polymerase (gp43) of T4-related phages.

Journal of Molecular Biology, 2010
In Escherichia coli phage T4 and many of its phylogenetic relatives, gene 43 consists of a single cistron that encodes a PolB family (PolB-type) DNA polymerase. We describe the divergence of this phage gene and its protein product (gp43) (gene product 43) among 26 phylogenetic relatives of T4 and discuss our observations in the context of diversity ...
V. Petrov, Swarnamala Ratnayaka, J. Karam   +2 more
semanticscholar   +3 more sources

DNA-based vaccination against murine paracoccidioidomycosis using the gp43 gene from paracoccidioides brasiliensis.

Vaccine, 2000
Gp43, the major 43-kDa antigenic glycoprotein of Paracoccidioides brasiliensis, or its 15-amino acid inner peptide (P10), induces a T-CD4(+), Th1 cellular immune response which protects BALB/c mice from intratracheal infection by virulent yeast forms. We investigated whether DNA vaccination using the gp43 gene could elicit protective immunity against P.
Aguinaldo R. Pinto, Aguinaldo R. Pinto, R. Puccia, Susana N Diniz, Marcelo Franco, L. Travassos   +5 more
semanticscholar   +4 more sources

Interaction between the T4 helicase loading protein (gp59) and the DNA polymerase (gp43): unlocking of the gp59-gp43-DNA complex to initiate assembly of a fully functional replisome.

Biochemistry, 2005
Single-molecule fluorescence resonance energy transfer and functional assays have been used to study the initiation and regulation of the bacteriophage T4 DNA replication system. Previous work has demonstrated that a complex of the helicase loading protein (gp59) and the DNA polymerase (gp43) on forked DNA totally inhibits the polymerase and ...
J. Xi, Zhiquan Zhang, Zhihao Zhuang, Jingsong Yang, Michelle M. Spiering, G. Hammes, S. Benkovic   +6 more
semanticscholar   +3 more sources

Expression and isoforms of gp43 in different strains of Paracoccidioides brasiliensis.

Medical Mycology, 1995
Individual exoantigens from 13 Paracoccidioides brasiliensis isolates were obtained and tested against a panel of 50 sera from patients with paracoccidioidomycosis by immunodiffusion test. The index of positivity varied from 20 to 100% according to the isolate.
M. C. Campos, J. Gesztesi, A. P. Vincentini, J. D. Lopes, Z. P. Camargo   +4 more
semanticscholar   +3 more sources

Peptides from Paracoccidioides brasiliensis GP43 inhibit macrophage functions and inflammatory response

Microbes and Infection, 2009
Paracoccidioidomycosis (PCM) is a systemic granulomatous disease caused by Paracoccidioides brasiliensis (Pb), a thermal dimorphic fungus. Its major antigen is a 43-kDa glycoprotein. Gp43 embodies different functions: it participates in evasion mechanisms during the installation of primary infection, stimulates granuloma-like formation in vitro and ...
Adriana Y C, Konno, Juliana T, Maricato, Fabiana T C, Konno, Mário, Mariano, José Daniel, Lopes   +4 more
openaire   +2 more sources

The gp43 from Paracoccidioides brasiliensis: A Major Diagnostic Antigen and Vaccine Candidate

, 2004
The gp43, a 43,000 dalton glycoprotein from Paracoccidioides brasiliensis, is one of those rare examples of a major diagnostic antigen in serological assays (e.g., Mendes-Giannini et al. 1990) that also contains epitopes eliciting an immunoprotective cellular immune response.
L. Travassos, C. Taborda, L. Iwai, E. Cunha-Neto, R. Puccia   +4 more
semanticscholar   +2 more sources

Diversity of structure and function of DNA polymerase (gp43) of T4-related bacteriophages

Biochemistry (Moscow), 2004
The replication DNA polymerase (gp43) of the bacteriophage T4 is a member of the pol B family of DNA polymerases, which are found in all divisions of life in the biosphere. The enzyme is a modularly organized protein that has several activities in one polypeptide chain (approximately 900 amino acid residues). These include two catalytic functions, POL (
V M, Petrov, J D, Karam
openaire   +2 more sources

Oral Immunization of Mice with a Nonantibiotic Recombinant Lactobacillus plantarum Coexpressing Trichinella spiralis TsNd and gp43 Protein Vaccine Combined with a Murine Interleukin-33 Adjuvant

Foodborne pathogens and disease
Trichinellosis, a zoonotic disease transmitted through food and caused by Trichinella spiralis, is a significant health concern worldwide. Therefore, developing a safe and effective vaccine to combat T. spiralis infection is essential.
Hongye Li, Dan Wang, Qiu-Yu Xie, Xin Liu, Junyi Li, Haibin Huang, Nan Wang, C. Shi, Tianxu Pan, Minghan Li, Dongyu Zhao, Shuiping Yu, Jiayao Guan, Guilian Yang   +13 more
semanticscholar   +1 more source

Molecular basis for oviductin-mediated processing from gp43 to gp41, the predominant glycoproteins of Xenopus egg envelopes.

Developmental Genetics, 1999
Acquisition of fertilizability in Xenopus coelomic eggs is correlated with the conversion from coelomic to vitelline envelope during passage of the eggs through the pars recta portion of oviduct. The conversion includes processing of a major envelope constituent gp43 of coelomic envelopes to gp41 of vitelline envelopes by a trypsin-type protease ...
H. Kubo, Miyuki Matsushita, Masaharu Kotani, Hiroshi Kawasaki, T. Saido, Seiichi Kawashima, Chiaki Katagiri, Akemi Suzuki   +7 more
semanticscholar   +3 more sources