Results 171 to 180 of about 2,352 (193)

GP43 from Paracoccidioides brasiliensis inhibits macrophage functions. An evasion mechanism of the fungus

Cellular Immunology, 2002
Macrophages constitute one of the primary cellular mechanisms that impairs parasite invasion of host tissues. The phagocytic and microbicidal properties of these cells can be modulated by specific membrane receptors involved in cell-microorganism interactions.
Ana Flavia Popi
exaly   +3 more sources

Virulence of Paracoccidioides brasiliensis and gp43 expression in isolates bearing known PbGP43 genotype

Microbes and Infection, 2005
Paracoccidioides brasiliensis is the dimorphic fungus responsible for human paracoccidioidomycosis (PCM). We previously observed that P. brasiliensis isolates bearing highly polymorphic PbGP43 of genotype A (Pb2, Pb3 and Pb4) were phylogenetically distant from the others.
Flavia Villaça Morais, Gustavo H. Goldman, Rosana Puccia   +2 more
exaly   +3 more sources

Diversity of structure and function of DNA polymerase (gp43) of T4-related bacteriophages

Biochemistry (Moscow), 2004
The replication DNA polymerase (gp43) of the bacteriophage T4 is a member of the pol B family of DNA polymerases, which are found in all divisions of life in the biosphere. The enzyme is a modularly organized protein that has several activities in one polypeptide chain (approximately 900 amino acid residues). These include two catalytic functions, POL (
V M, Petrov, J D, Karam
exaly   +5 more sources

Interaction between the T4 Helicase Loading Protein (gp59) and the DNA Polymerase (gp43):  Unlocking of the gp59−gp43−DNA Complex to Initiate Assembly of A Fully Functional Replisome

Biochemistry, 2005
Single-molecule fluorescence resonance energy transfer and functional assays have been used to study the initiation and regulation of the bacteriophage T4 DNA replication system. Previous work has demonstrated that a complex of the helicase loading protein (gp59) and the DNA polymerase (gp43) on forked DNA totally inhibits the polymerase and ...
Jun, Xi, Zhiquan, Zhang, Zhihao, Zhuang, Jingsong, Yang, Michelle M, Spiering, Gordon G, Hammes, Stephen J, Benkovic   +6 more
openaire   +2 more sources

Immunization of susceptible mice with gp43-pulsed dendritic cells induce an increase of pulmonary Paracoccidioidomycosis

Immunology Letters, 2006
The development of the appropriate CD4 Th subset is important for disease resolution and several studies have shown that different outcomes of a disease can be obtained by influencing the commitment of precursors to either, Th1 or Th2 lineage. Dendritic cells (DCs) are able to initiate response in naïve T cells and they also participate in Th cell ...
Karen Spadari Ferreira
exaly   +3 more sources

DNA-based vaccination against murine paracoccidioidomycosis using the gp43 gene from Paracoccidioides brasiliensis

Vaccine, 2000
Gp43, the major 43-kDa antigenic glycoprotein of Paracoccidioides brasiliensis, or its 15-amino acid inner peptide (P10), induces a T-CD4(+), Th1 cellular immune response which protects BALB/c mice from intratracheal infection by virulent yeast forms. We investigated whether DNA vaccination using the gp43 gene could elicit protective immunity against P.
Aguinaldo R Pinto, Rosana Puccia, Susana N Diniz   +2 more
exaly   +4 more sources

Yeast Expressing Gp43 Protein as a Vaccine Against Paracoccidioides brasiliensis Infection

2017
Paracoccidioidomycosis (PCM) represents the most frequent systemic mycosis in Latin American. The disease is caused by the pathogenic thermally dimorphic fungus Paracoccidioides brasiliensis, and is initially characterized by pulmonary lesions, which can subsequently disseminate to other organs, resulting in secondary injuries.
Aline Ferreira, Oliveira, Paulo S R, Coelho   +1 more
openaire   +2 more sources

Augmentation of IgM Antibody to gp43 Tumor-Associated Antigen Peptide by Melanoma Cell Vaccine

Journal of Clinical Immunology, 1998
We previously reported that gp43 tumor-associated antigen peptide (DLTMKYQIF; designated 810 antigen) on human melanoma cells is recognized by IgM human monoclonal antibody L92 and by cytotoxic T lymphocytes (CTL). In this study, we retrospectively tested sera of 44 patients with regional metastatic melanoma (22 who recurred within 1 year and 22 who ...
T, Takahashi, A, Conforti, Y, Kikumoto, D S, Hoon, D L, Morton, R F, Irie   +5 more
openaire   +2 more sources

Diagnosis of paracoccidioidomycosis by passive haemagglutination assay of antibody using a purified and specific antigen-gp43

Medical Mycology, 1993
Sheep red blood cells, treated with glutaraldehyde and sensitized with a purified Paracoccidioides brasiliensis antigen of molecular mass 43 kDa (gp43), were used to detect antibodies to P. brasiliensis by passive haemagglutination (PHA). Sera from 50 patients with paracoccidioidomycosis had PHA titres of > 1/800, and had antibodies detectable by ...
C P, Taborda, Z P, Camargo
openaire   +2 more sources

Genetic Insertions and Diversification of the PolB-Type DNA Polymerase (gp43) of T4-Related Phages

Journal of Molecular Biology, 2010
In Escherichia coli phage T4 and many of its phylogenetic relatives, gene 43 consists of a single cistron that encodes a PolB family (PolB-type) DNA polymerase. We describe the divergence of this phage gene and its protein product (gp43) (gene product 43) among 26 phylogenetic relatives of T4 and discuss our observations in the context of diversity ...
Vasiliy M, Petrov, Swarnamala, Ratnayaka, Jim D, Karam   +2 more
openaire   +2 more sources