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Granuloma formation in vitro requires B-1 cells and is modulated by Paracoccidioides brasiliensis gp43 antigen

Microbes and Infection, 2006
The mechanisms that determine granuloma formation and the significance of this type of inflammatory response in the pathogenesis of fungal diseases such as paracoccidioidomycosis are far from fully understood. We developed a granuloma model in vitro using beads to evaluate the role of isolated mouse peritoneal macrophages and B-1 cells.
Ana Flávia, Vigna   +5 more
openaire   +2 more sources

The gp43 from Paracoccidioides brasiliensis: A Major Diagnostic Antigen and Vaccine Candidate

2004
The gp43, a 43,000 dalton glycoprotein from Paracoccidioides brasiliensis, is one of those rare examples of a major diagnostic antigen in serological assays (e.g., Mendes-Giannini et al. 1990) that also contains epitopes eliciting an immunoprotective cellular immune response.
Luiz R. Travassos   +4 more
openaire   +1 more source

Lack of reactivity of paracoccidioidomycosis sera in the double immunodiffusion test with the gp43 antigen: report of two cases

Medical Mycology, 1995
Sera from two patients with chronic active paracoccidioidomycosis yielded negative double immunodiffusion results with a culture filtrate antigen from Paracoccidioides brasiliensis routinely used in our laboratory. Complement fixation tests were positive for both sera using a polysaccharide-rich antigen.
G M, del Negro   +7 more
openaire   +2 more sources

Biochemical and genetic studies on GP43, a 43-kD glycoprotein detected immunologically in human urine and serum

Biochemical Genetics, 1989
A new and previously undescribed glycoprotein with a molecular weight of 43,000 has been isolated from human urine. This protein, designated GP43; copurified with ribonuclease, which has the same molecular weight, but ribonuclease activity was removed by passage through an affinity column of agarose-5'-(4-aminophenyl phosphoryl) uridine 2'(3 ...
K, Mizuta, T, Yasuda, K, Kishi
openaire   +2 more sources

Molecular basis for oviductin-mediated processing from gp43 to gp41, the predominant glycoproteins ofXenopus egg envelopes

Developmental Genetics, 1999
Acquisition of fertilizability in Xenopus coelomic eggs is correlated with the conversion from coelomic to vitelline envelope during passage of the eggs through the pars recta portion of oviduct. The conversion includes processing of a major envelope constituent gp43 of coelomic envelopes to gp41 of vitelline envelopes by a trypsin-type protease ...
H, Kubo   +7 more
openaire   +2 more sources

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