Results 121 to 130 of about 1,699 (149)
Some of the next articles are maybe not open access.
Orphan G Protein-Coupled Receptor GPR37 as an Emerging Therapeutic Target
ACS Chemical Neuroscience, 2023G protein-coupled receptors (GPCRs) are successful druggable targets, making up around 35% of all FDA-approved medications. However, a large number of receptors remain orphaned, with no known endogenous ligand, representing a challenging but untapped area to discover new therapeutic targets.
Andrew A. Bolinger +4 more
openaire +2 more sources
GPR37 modulates progenitor cell dynamics in a mouse model of ischemic stroke
Experimental Neurology, 2021The generation of neural stem and progenitor cells following injury is critical for the function of the central nervous system, but the molecular mechanisms modulating this response remain largely unknown. We have previously identified the G protein-coupled receptor 37 (GPR37) as a modulator of ischemic damage in a mouse model of stroke.
Owino, Sharon +11 more
openaire +3 more sources
Loss of GPR37 Increases Susceptibility to Demyelination
The FASEB Journal, 2016GPR37 is an orphan G protein‐coupled receptor that is highly expressed in the brain. Previous work has shown that GPR37 is a receptor for the secreted neuroprotective and glioprotective factor prosaposin and that prosaposin acts through GPR37 to protect cultured astrocytes from oxidative stress‐induced cell death (Meyer et al., Proc. Natl. Acad.
Brilee M. Coleman +3 more
openaire +1 more source
Induction of macroautophagy by overexpression of the Parkinson's disease‐associated GPR37 receptor
The FASEB Journal, 2009ABSTRACT The orphan G‐protein‐coupled receptor 37 (GPR37) is a substrate of parkin, and its insoluble aggregates accumulate in brain tissue samples of Parkinson's disease patients, including Lewy bodies and neurites. Parkin activates the clearance of the unfolded receptor, while the overexpression of GPR37, in the
Marazziti D +5 more
openaire +3 more sources
Folding Underlies Bidirectional Role of GPR37/Pael-R in Parkinson Disease
Trends in Pharmacological Sciences, 2017Since conformational flexibility, which is required for the function of a protein, comes at the expense of structural stability, many proteins, including G-protein-coupled receptors (GPCRs), are under constant risk of misfolding and aggregation. In this regard GPR37 (also named PAEL-R and ETBR-LP-1) takes a prominent role, particularly in relation to ...
Lina, Leinartaité, Per, Svenningsson
openaire +2 more sources
The pathological role of Pael-receptor/GPR37 in AR-JP
Parkinsonism & Related Disorders, 2006Autosomal recessive juvenile parkinsonism (AR-JP) is caused by mutations in the parkin gene. Parkin is a ubiquitin ligase that ubiquitinates and promotes the proteasome-mediated degradation of its substrate protein. Therefore, the accumulation of the substrate(s) of Parkin is thought to lead to AR-JP.
openaire +1 more source
Clinica Chimica Acta
G protein-coupled receptor 37 (GPR37) has recently been earmarked as a rising candidate for use as a marker for central nervous system (CNS) demyelinating illness. In this study, we explored the ability of serum GPR37 to assess disease activity, functional impairment, and the efficacy of therapeutic interventions in patient cases of neuromyelitis ...
Xiaotong Li +9 more
openaire +2 more sources
G protein-coupled receptor 37 (GPR37) has recently been earmarked as a rising candidate for use as a marker for central nervous system (CNS) demyelinating illness. In this study, we explored the ability of serum GPR37 to assess disease activity, functional impairment, and the efficacy of therapeutic interventions in patient cases of neuromyelitis ...
Xiaotong Li +9 more
openaire +2 more sources
Elucidating Signaling Mechanisms and Pharmacology for the Brain Orphan Receptor GPR37
The Journal of Pharmacology and Experimental Therapeutics, 2023Andrew Frazier, John A. Allen
openaire +1 more source