Results 141 to 150 of about 1,817 (168)
Triggering the succinate receptor GPR91 on dendritic cells enhances immunity
Nature Immunology, 2008 Succinate acts as an extracellular mediator signaling through the G protein-coupled receptor GPR91. Here we show that dendritic cells had high expression of GPR91. In these cells, succinate triggered intracellular calcium mobilization, induced migratory responses and acted in synergy with Toll-like receptor ligands for the production of proinflammatory
José M Carballido +2 more
exaly +4 more sources
Insight into SUCNR1 (GPR91) structure and function [PDF]
Pharmacology & Therapeutics, 2016 SUCNR1 (or GPR91) belongs to the family of G protein-coupled receptors (GPCR), which represents the largest group of membrane proteins in human genome. The majority of marketed drugs targets GPCRs, directly or indirectly. SUCNR1 has been classified as an orphan receptor until a landmark study paired it with succinate, a citric acid cycle intermediate ...
Julien Hanson +2 more
exaly +5 more sources
Succinate receptor GPR91, a Gαi coupled receptor that increases intracellular calcium concentrations through PLCβ [PDF]
FEBS Letters, 2013 Succinate has been reported as the endogenous ligand for GPR91. In this study, succinate was confirmed to activate GPR91 resulting in both 3′–5′-cyclic adenosine monophosphate (cAMP) inhibition and inositol phosphate formation in a pertussis toxin (PTX ...
Peter J Greasley +2 more
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GPR91: expanding the frontiers of Krebs cycle intermediates [PDF]
Cell Communication and Signaling, 2016 Since it was discovered, the citric acid cycle has been known to be central to cell metabolism and energy homeostasis. Mainly found in the mitochondrial matrix, some of the intermediates of the Krebs cycle are also present in the blood stream. Currently, there are several reports that indicate functional roles for Krebs intermediates out of its cycle ...
Matheus C Fonseca, M Fatima Leite
exaly +4 more sources
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Expression and localization of GPR91 and GPR99 in murine organs
Cell and Tissue Research, 2015Energy substrates and metabolic intermediates are proven ligands of a growing number of G-protein coupled receptors. In 2004, GPR91 and GPR99 were identified as receptors for the citric acid cycle intermediates, succinate and α-ketoglutarate, respectively.
Wolfgang Kummer +2 more
exaly +3 more sources
Involvement of GPR91 in the perception of the umami-like shellfish taste of succinate
Food ChemistrySuccinate is a key component of the characteristic umami-like taste of shellfish, which is similar to the umami taste elicited by glutamate, but is slightly more persistent and astringent. The taste receptors involved in the perception of succinate currently remain unknown.
Motonaka Kuroda +2 more
exaly +3 more sources
Cell selectivity in succinate receptor SUCNR1/GPR91 signaling in skeletal muscle
American Journal of Physiology - Endocrinology and Metabolism, 2023 Succinate is released by skeletal muscle during exercise and activates SUCNR1/GPR91. Signaling of SUCNR1 is involved in cell-cell communication in skeletal muscle.
Anna Krook +2 more
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GPR91, a critical signaling mechanism in modulating pathophysiologic processes in chronic illnesses
The FASEB Journal, 2020Abstract Succinate receptor GPR91 is one of G protein‐coupled receptors (GPCRs), and is expressed in a variety of cell types and tissues. Succinate is its natural ligand, and its activation represents that an intrinsic metabolic intermediate exerts a regulatory role on many critical life processes involving pathophysiologic mechanisms,
Xinyi, Li +6 more
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Receptor GPR91 contributes to voiding function and detrusor relaxation mediated by succinate
Neurourology and Urodynamics, 2020AbstractAimSuccinate activates the receptor GPR91 identified in the bladder. The present study aims to unravel the mechanisms of bladder relaxation by succinate and how the receptor is involved in structural and functional changes of the bladder.MethodsPhysiological recordings of bladder function were carried out by cystometry and organ bath from C57BL/
Abubakr Mossa +3 more
openaire +2 more sources
Succinate, increased in metabolic syndrome, activates GPR91 receptor signaling in urothelial cells
Cellular Signalling, 2017Metabolic syndrome is associated with overactive bladder syndrome (OAB) and increased circulating levels of succinate, an intermediate of the Krebs cycle. The urothelium is an essential regulator of bladder muscle contraction. This study aimed to determine if GPR91, the succinate receptor, is expressed and functional in the bladder.
Lysanne Campeau +2 more
exaly +3 more sources