Results 151 to 160 of about 1,817 (168)

Succinate causes α-SMA production through GPR91 activation in hepatic stellate cells

Biochemical and Biophysical Research Communications, 2015
Succinate acts as an extracellular signaling molecule as well as an intermediate in the citric acid cycle. It binds to and activates its specific G protein-coupled receptor 91 (GPR91). GPR91 is present in hepatic stellate cells (HSCs), but its role in hepatic fibrogenesis remains unclear.
Eun-Hee Cho, Daehee Choi
exaly   +3 more sources

The succinate receptor GPR91 in neurons has a major role in retinal angiogenesis

Nature Medicine, 2008
Vascularization is essential for tissue development and in restoration of tissue integrity after an ischemic injury. In studies of vascularization, the focus has largely been placed on vascular endothelial growth factor (VEGF), yet other factors may also orchestrate this process.
Przemyslaw, Sapieha, Mirna, Sirinyan, David, Hamel, Karine, Zaniolo, Jean-Sébastien, Joyal, Jang-Hyeon, Cho, Jean-Claude, Honoré, Elsa, Kermorvant-Duchemin, Daya R, Varma, Sophie, Tremblay, Martin, Leduc, Lenka, Rihakova, Pierre, Hardy, William H, Klein, Xiuqian, Mu, Orval, Mamer, Pierre, Lachapelle, Adriana, Di Polo, Christian, Beauséjour, Gregor, Andelfinger, Grant, Mitchell, Florian, Sennlaub, Sylvain, Chemtob   +22 more
openaire   +2 more sources

Metformin ameliorates activation of hepatic stellate cells and hepatic fibrosis by succinate and GPR91 inhibition

Biochemical and Biophysical Research Communications, 2018
Chronic liver disease is becoming a major cause of morbidity and mortality worldwide. During liver injury, hepatic stellate cells (HSCs) trans-differentiate into activated myofibroblasts, which produce extracellular matrix. Succinate and succinate receptor (G-protein coupled receptor91, GPR91) signaling pathway has now emerged as a regulator of ...
Won Sun Park, Eun-Hee Cho, So Young Park
exaly   +3 more sources

From Mechanisms to Diseases: The Succinate-GPR91 Axis in Cardiometabolic Diseases

Journal of Cardiovascular Translational Research
Cardiometabolic diseases (CMD) encompass a cluster of cardiovascular disorders primarily driven by metabolic dysregulation, such as obesity-associated cardiomyopathy, hypertensive heart disease, and diabetic cardiomyopathy. The pathogenesis of CMD is closely linked to chronic inflammation, myocardial hypertrophy, and mitochondrial energy metabolism ...
Yumeng Jia, Lei Wang
exaly   +3 more sources

Neovascularization in retinopathy of prematurity: opposing actions of neuronal factors GPR91 and semaphorins 3A

Acta Paediatrica, 2012
AbstractRetinopathy of prematurity (ROP) is a major cause of severe visual deficits in children. This review focuses on the role of newly identified factors from retinal neurons, which through their opposing actions on vascular development contribute to ROP.
Jean-Sébastien, Joyal, Samy, Omri, Nicholas, Sitaras, José-Carlos, Rivera, Przemyslaw, Sapieha, Sylvain, Chemtob   +5 more
openaire   +2 more sources

Acod1 negatively impacts osteoclastogenesis via GPR91-mediated NFATc1 activation

2022
Abstract Immune cells undergo metabolic reprogramming upon exposure to inflammatory stimuli. The immuneresponsive gene 1 ( Irg1 ) encodes aconitate decarboxylase (Acod1), an enzyme that generates itaconate from cis-aconitate in the TCA cycle and is one of the most highly induced ...
Yue Gao, Franziska V. Kraus, Elisabeth Seebach, Sushmita Chakraborty, Dominik Schaack, Judith Schenz, Willi Wagner, Katharina F. Kubatzky   +7 more
openaire   +1 more source

Suppressing MASH fibrotic progression by blocking succinate-GPR91 signaling in HSCs

Hepatology
Background and Aims: The succinate receptor GPR91 is highly expressed in HSCs, with its expression further elevated during metabolic dysfunction–associated steatohepatitis (MASH)-induced fibrotic progression. However, convincing in vivo data on whether blocking GPR91 signaling leads to fibrotic regression in ...
Li Xie, Hui Chen, Li Zhang, Yong-Yu Yang, Yuan Zhou, Yue Ma, Chang Liu, Yu-Li Wang, Qin Zhu, Ya-Jun Yan, Jia Ding, Ning-Ping Zhang, Qiang Deng, Xiu-Ping Liu, Wei Jiang, Jian Wu   +15 more
openaire   +2 more sources

Role of the succinate and GPR91 pathway in atrial fibrillation mechanisms

Archives of Cardiovascular Diseases Supplements, 2023
Bastien Guillot, Guido Caluori, Richard Walton, Virginie Loyer, Pierre Jaïs, Philippe Pasdois, Olivier Bernus   +6 more
openaire   +1 more source

GPR91 and GPR99 in murine sympathetic and sensory neurons

Autonomic Neuroscience, 2013
R. Paddenberg, J. Diehl, B. Gries, L. Wessels, U. Pfeil, W. Kummer   +5 more
openaire   +1 more source

Succinate Receptor Gpr91 Knockout Attenuates Hypoxic Pulmonary Hypertension in Mice

C56. COW HOLLOW: PRECLINICAL MODELS OF PULMONARY HYPERTENSION, 2022
P.P. Jain, M. Xiong, N. Lai, J. Chen, A. Makino, J.X.-. Yuan   +5 more
openaire   +1 more source