Results 41 to 50 of about 165,440 (238)
Gaceta Sanitaria, 2020 Resumen: Existe un creciente interés por encontrar respuestas innovadoras para evaluar intervenciones complejas en salud pública. En esta nota metodológica, se presenta la teoría del cambio como una herramienta útil para facilitar tanto la planificación ...
Viola Cassetti +1 more
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Advanced Science, EarlyView.Cancer cell‐intrinsic cholesterol promotes the S‐palmitoylation of SP1, increasing its nuclear translocation and driving the transcription and secretion of MDK, which in turn facilitates the differentiation of macrophages into a lipid‐associated phenotype.
Shirong Peng +12 more
wiley +1 more source
LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1
Advanced Science, EarlyView.LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li +12 more
wiley +1 more source
Streptococcus pneumoniae - an uncommon cause of neonatal sepsis: two case reports
Sri Lankan Journal of Infectious Diseases, 2022 Streptococcus pneumoniae is a rare but recognized aetiological agent for neonatal sepsis. In the context of scarce local data, we report two cases of early-onset neonatal sepsis (EONS) due to pneumococci that probably occurred following ascending ...
GCS Gunasekera +3 more
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Cleavage‐Resistant CYLD Protects Against Autoimmune Hepatitis
Advanced Science, EarlyView.Proteolytic cleavage of the deubiquitinase CYLD emerges as a critical driver of autoimmune hepatitis. TNFα‐induced CYLD loss in macrophages amplifies S100A9‐triggered MAPK activation, leading to excessive chemokine production and hepatic inflammation. Pharmacological inhibition of MEK signaling effectively attenuates experimental disease, highlighting ...
Han Liu +13 more
wiley +1 more source
Advanced Science, EarlyView.Elevated exogenous palmitic acid promotes the S‐palmitoylation of SRPK1 in endothelial cells, a dynamic process governed by ZDHHC24 and APT1. This post‐translational modification strengthens the interaction between SRPK1 and the E3 ubiquitin ligase MIB1, thereby facilitating the proteasomal degradation of SRPK1.
Xiao‐Hui Tan +11 more
wiley +1 more source
Advanced Science, EarlyView.Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen +9 more
wiley +1 more source
RTDGPS Implementation by Online Prediction of GPS Position Components Error Using GA-ANN Model [PDF]
Journal of Electrical and Computer Engineering Innovations, 2013 If both Reference Station (RS) and navigational device in Differential Global Positioning System (DGPS) receive signals from the same satellite, RS Position Components Error (RPCE) can be used to compensate for navigational device error.
M. H. Refan, A. Dameshghi
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Advanced Science, EarlyView.This review comprehensively overviews attenuated bacteria‐based tumor therapy, highlighting key methodologies and recent progress. It examines strategies for enhancing safety, stabilizing efficacy, optimizing manufacturing, and navigating regulatory pathways.
Yucheng Liu +8 more
wiley +1 more source
ASSESSMENT OF THE FIRE RISK IN OIL PRODUCTS TRANSPORT DEPENDING ON THE AREA OF SPILL
Известия высших учебных заведений: Нефть и газ, 2015 The character of impact of the flammable liquids spill area in assessing the fire hazard of transport facilities in oil and gas industry was determined. The area of spill was defined for gasoline of trademark AI-92.
V. D. Khalikov, F. Sh. Hafizov
doaj +1 more source