Results 131 to 140 of about 4,333 (173)

The Role of A-Kinase Anchoring Proteins for Inhibitory cAMP Signalling in Platelets. [PDF]

Cells
Barkey S, Smolenski A.
europepmc   +1 more source

Contrasting Effects of Platelet GPVI Deletion Versus Syk Inhibition on Mouse Jugular Vein Puncture Wound Structure. [PDF]

Int J Mol Sci
Pokrovskaya ID, Ball KK, Webb MW, Joshi S, Rhee SW, Ware J, Storrie B.   +6 more
europepmc   +1 more source

Correction: Thymidine phosphorylase in nucleotide metabolism: physiological functions and its implications in tumorigenesis and anti-cancer therapy. [PDF]

Front Immunol
Huang B, Yuan Q, Sun J, Wang C, Yang D.
europepmc   +1 more source

Rac Inhibition Causes Impaired GPVI Signalling in Human Platelets through GPVI Shedding and Reduction in PLCγ2 Phosphorylation

International Journal of Molecular Sciences, 2022
Rac1 is a small Rho GTPase that is activated in platelets upon stimulation with various ligands, including collagen and thrombin, which are ligands for the glycoprotein VI (GPVI) receptor and the protease-activated receptors, respectively. Rac1-deficient murine platelets have impaired lamellipodia formation, aggregation, and reduced PLCγ2 activation ...
Raluca A I Neagoe, Elizabeth E Gardiner, David Stegner   +2 more
exaly   +5 more sources

GPVI and CLEC‐2 in hemostasis and vascular integrity [PDF]

Journal of Thrombosis and Haemostasis, 2010
The glycoprotein VI (GPVI)-FcR gamma-chain complex initiates powerful activation of platelets by the subendothelial matrix proteins collagen and laminin through an immunoreceptor tyrosine-based activation motif (ITAM)-regulated signaling pathway. ITAMs are characterized by two YxxL sequences separated by 6-12 amino acids and are found associated with ...
Steve P Watson
exaly   +3 more sources

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EMMPRIN (CD147) is a novel receptor for platelet GPVI and mediates platelet rolling via GPVI-EMMPRIN interaction

Thrombosis and Haemostasis, 2009
SummaryThe Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, CD147, basigin) is an immunoglobulin-like receptor expressed in various cell types. During cellular interactions homotypic EMMPRIN-EMMPRIN interactions are known to induce the synthesis of matrix metalloproteinases. Recently, we have identified EMMPRIN as a novel receptor on platelets.
Peter Seizer, Harald F Langer, Konstantinos Stellos   +2 more
exaly   +3 more sources

Relative antithrombotic effect of soluble GPVI dimer compared with anti-GPVI antibodies in mice

Blood, 2005
AbstractGlycoprotein VI (GPVI) is an essential platelet collagen receptor; therefore, the inhibition of GPVI-collagen interactions may be an attractive antithrombotic strategy. We have previously shown that targeting of GPVI with antibodies leads to the depletion of the receptor and to long-term antithrombotic protection in mice.
Sabine, Grüner, Miroslava, Prostredna, Martina, Koch, Yoshiki, Miura, Valerie, Schulte, Stephanie M, Jung, Masaaki, Moroi, Bernhard, Nieswandt   +7 more
openaire   +2 more sources

Presence of platelet-associated anti-glycoprotein (GP)VI autoantibodies and restoration of GPVI expression in patients with GPVI deficiency [PDF]

Journal of Thrombosis and Haemostasis, 2009
Glycoprotein (GP)VI deficiency is a rare platelet disorder with a mild bleeding tendency. However, its pathophysiology remains unclear.We characterized a novel GPVI-deficient patient with immune thrombocytopenic purpura and searched for the presence of anti-GPVI autoantibodies in this and another patient with GPVI deficiency.A 12-year-old Japanese girl
Hirokazu Kashiwagi, M Moroi, M C Berndt   +2 more
exaly   +4 more sources