Platelet surface receptor glycoprotein VI-dimer is overexpressed in stroke: The Glycoprotein VI in Stroke (GYPSIE) study results. [PDF]
PLoS ONE, 2022 ObjectivesPlatelet activation underpins thrombus formation in ischemic stroke. The active, dimeric form of platelet receptor glycoprotein (GP) VI plays key roles by binding platelet ligands collagen and fibrin, leading to platelet activation.
Isuru Induruwa +17 more
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Sequence-specific 2'-O-methoxyethyl antisense oligonucleotides activate human platelets through glycoprotein VI, triggering formation of platelet-leukocyte aggregates [PDF]
Haematologica, 2021 Antisense oligonucleotides (ASO) are DNA-based, disease-modifying drugs. Clinical trials with 2'-O-methoxyethyl (2’MOE) ASO have shown dose- and sequence-specific lowering of platelet counts according to two phenotypes.
Martina H. Lundberg Slingsby +14 more
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Sinomenium acutum Modulates Platelet Aggregation and Thrombus Formation by Regulating the Glycoprotein VI-Mediated Signalosome in Mice [PDF]
Pharmaceuticals, 2023 Sinomenium acutum (SA) has long been used as a traditional medicine in China, Japan, and Korea to treat a wide range of diseases. It has been traditionally used to ameliorate inflammation and improve blood circulation.
Yeon-Ji Kim +4 more
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Minimal Collagen-Binding Epitope of Glycoprotein VI in Human and Mouse Platelets [PDF]
Biomedicines, 2023 Glycoprotein VI (GPVI) is a platelet-specific receptor for collagen and fibrin, regulating important platelet functions such as platelet adhesion and thrombus growth. Although the blockade of GPVI function is widely recognized as a potent anti-thrombotic
Chao Han +15 more
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Research advances on platelet glycoprotein VI in ischemic stroke [PDF]
Thrombosis JournalAtherosclerosis is one cause of ischemic stroke. Subcutaneous collagen is exposed when the fibrous cap of an atherosclerotic plaque ruptures. Platelets bind to collagen, leading to platelet activation, aggregation, and thrombus formation.
Hanlu Xiang +5 more
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Colchicine inhibits ROS generation in response to glycoprotein VI stimulation [PDF]
Scientific Reports, 2021 Colchicine inhibits coronary and cerebrovascular events in patients with coronary artery disease (CAD), and although known to have anti-inflammatory properties, its mechanisms of action are incompletely understood.
G. J. Pennings +5 more
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Immobilized fibrinogen activates human platelets through glycoprotein VI [PDF]
Haematologica, 2018 Glycoprotein VI, a major platelet activation receptor for collagen and fibrin, is considered a particularly promising, safe antithrombotic target. In this study, we show that human glycoprotein VI signals upon platelet adhesion to fibrinogen.
Pierre H Mangin +18 more
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Functional characterization of a nanobody-based glycoprotein VI-specific platelet agonist [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Glycoprotein (GP)VI is a platelet-specific collagen receptor required for platelet activation during hemostasis. Platelet reactivity toward collagen is routinely assessed during diagnostic workup of platelet disorders.
Minka Zivkovic +74 more
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Janus kinase inhibitors ruxolitinib and baricitinib impair glycoprotein-VI mediated platelet function [PDF]
Platelets, 2022 Several Janus kinase (JAK) inhibitors (jakinibs) have recently been approved to treat inflammatory, autoimmune and hematological conditions. Despite emerging roles for JAKs and downstream signal transducer and activator of transcription (STAT) proteins ...
Iván Parra-Izquierdo +9 more
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Platelet glycoprotein VI promotes folic acid-induced acute kidney injury through interaction with tubular epithelial cell-derived galectin-3 [PDF]
Cell Communication and SignalingBackground Acute kidney injury (AKI) is defined by a significant reduction in renal function, which subsequently impairs coagulation and activates the inflammatory immune response, ultimately resulting in damage to renal tubular epithelial cells (TECs ...
Ya-Wei Guo +8 more
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