Results 31 to 40 of about 43,195 (149)

The relationship between platelet glycoprotein VI T13254C polymorphism and acute myocardial infarction (MI) [PDF]

open access: yesپیاورد سلامت, 2011
Background and Aim: Myocardial infarction (MI) is a major cause of morbidity and mortality worldwide. Epidemiological studies indicate that MI results from complex interactions between long-term environmental influences, concomitant disorders, and ...
A Fatemi   +4 more
doaj   +1 more source

Increased platelet reactivity as measured by plasma glycoprotein VI in gout

open access: yesPlatelets, 2018
Patients with gout have an increased risk of cardiovascular events. The glycoprotein VI (GPVI) receptor is found exclusively on platelets and megakaryocytes, is proteolytically cleaved upon platelet activation, and detectable in plasma as soluble GPVI ...
Richard Conway   +10 more
doaj   +1 more source

Sanguinarine Attenuates Collagen-Induced Platelet Activation and Thrombus Formation

open access: yesBiomedicines, 2021
Sanguinarine, a benzophenanthridine alkaloid, has been described to have an antiplatelet activity. However, its antithrombotic effect and the mechanism of platelet inhibition have not thoroughly been explored.
Dan Shu   +9 more
doaj   +1 more source

Posttranslational modifications of platelet adhesion receptors

open access: yesPharmacological Research, 2022
Platelets play a key role in normal hemostasis, whereas pathological platelet adhesion is involved in various cardiovascular events. The underlying cause in cardiovascular events involves plaque rupture leading to subsequent platelet adhesion, activation,
Shukun Sun   +5 more
doaj   +1 more source

Antiplatelet Activity of Tussilagone via Inhibition of the GPVI Downstream Signaling Pathway in Platelets

open access: yesFrontiers in Medicine, 2020
Tussilagone is a sesquiterpenoid extracted from Tussilago farfara and is used as an oriental medicine for asthma and bronchitis. Although previous studies have shown that tussilagone has an inhibitory effect on platelet aggregation, no studies have been ...
Jing Zhou   +4 more
doaj   +1 more source

Enhanced stability of the SARS CoV-2 spike glycoprotein following modification of an alanine cavity in the protein core.

open access: yesPLoS Pathogens, 2023
The spike (S) glycoprotein of SARS CoV-2 is the target of neutralizing antibodies (NAbs) that are crucial for vaccine effectiveness. The S1 subunit binds ACE2 while the S2 subunit mediates virus-cell membrane fusion.
Pantelis Poumbourios   +12 more
doaj   +1 more source

Polymerized fibrin activates glycoprotein VI [PDF]

open access: yesBlood, 2015
In this issue of Blood , [Mammadova-Bach et al][1] show that polymerized fibrin binds to the platelet receptor glycoprotein VI (GPVI), amplifying thrombin generation and enhancing thrombus growth.[1][2] ![Figure][3] GPVI amplifies thrombin generation and platelet aggregation. PS,
openaire   +2 more sources

Collagen can selectively trigger a platelet secretory phenotype via glycoprotein VI. [PDF]

open access: yesPLoS ONE, 2014
Platelets are not only central actors of hemostasis and thrombosis but also of other processes including inflammation, angiogenesis, and tissue regeneration.
Véronique Ollivier   +6 more
doaj   +1 more source

Atroxlysin-III, A Metalloproteinase from the Venom of the Peruvian Pit Viper Snake Bothrops atrox (Jergón) Induces Glycoprotein VI Shedding and Impairs Platelet Function

open access: yesMolecules, 2019
Atroxlysin-III (Atr-III) was purified from the venom of Bothrops atrox. This 56-kDa protein bears N-linked glycoconjugates and is a P-III hemorrhagic metalloproteinase.
Luciana S. Oliveira   +8 more
doaj   +1 more source

An optimized herbal medicine containing Scutellaria baicalensis Georgi, Alisma orientale Juzepzuk, and Atractylodes japonica Koidzumi has potent antiplatelet and antithrombotic activities

open access: yesJournal of Traditional and Complementary Medicine, 2023
Background and aim: Platelet-derived thrombosis is important in the pathogenesis of cardiovascular diseases. HTB is an optimized herbal medicine including Scutellaria baicalensis Georgi, Alisma orientale Juzepzuk, and Atractylodes japonica Koidzumi.
Yeon-Ji Kim, Tae In Kim, Kyungho Kim
doaj   +1 more source

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