Results 51 to 60 of about 43,195 (149)

Decreased levels of platelet-derived soluble glycoprotein VI detected prior to the first diagnosis of coronary artery disease in HIV-positive individuals

Platelets, 2017
HIV-positive patients are at increased risk for coronary artery disease (CAD); changes in platelet activation may play a role. This study was performed to determine if levels of soluble glycoprotein VI (sGPVI), a platelet-specific marker of activation ...
J. M. Trevillyan, E. E. Gardiner, R. K. Andrews, A. Maisa, A. C. Hearps, M. Al-Tamimi, S. M. Crowe, J. F. Hoy   +7 more
doaj   +1 more source

Alboaggregin A activates platelets by a mechanism involving glycoprotein VI as well as glycoprotein Ib

Blood, 2001
Abstract The snake venom C-type lectin alboaggregin A (or 50-kd alboaggregin) from Trimeresurus albolabris was previously shown to be a platelet glycoprotein (GP) Ib agonist. However, investigations of the signal transduction induced in platelets showed patterns of tyrosine phosphorylation that were different from those of other GPIb ...
Dörmann, D, Clemetson, JM, Navdaev, A, Kehrel, BE, Clemetson, Kenneth John   +4 more
openaire   +4 more sources

The basement membrane protein nidogen-1 supports platelet adhesion and activation

Platelets, 2021
The core structure of the extracellular basement membrane is made up of self-assembling networks of collagen and laminin which associate with each other through the bridging adapter proteins including the sulfated monomeric glycoprotein nidogen.
Hari Hara Sudhan Lakshmanan, Alexander R. Melrose, Anna-Liisa I. Sepp, Annachiara Mitrugno, Anh T. P. Ngo, Ayesha Khader, Rachel Thompson, Daniel Sallee, Jiaqing Pang, Pierre H. Mangin, Martine Jandrot-Perrus, Joseph E. Aslan, Owen J.T. McCarty   +12 more
doaj   +1 more source

New potential biomarkers for early chronic kidney disease diagnosis in patients with different glucose tolerance status

Frontiers in Endocrinology, 2023
BackgroundThe purpose of the present study was to investigate the role of oxidative stress, platelet activation, and endocan levels in renal dysfunction in normal glucose tolerance (NGT) patients with 1-h plasma glucose values ≥155 mg/dl (NGT ≥ 155 ...
Velia Cassano, Corrado Pelaia, Giuseppe Armentaro, Sofia Miceli, Valeria Tallarico, Daniele Dallimonti Perini, Vanessa T. Fiorentino, Egidio Imbalzano, Raffaele Maio, Elena Succurro, Marta L. Hribal, Francesco Andreozzi, Giorgio Sesti, Angela Sciacqua   +13 more
doaj   +1 more source

A compound heterozygous mutation in glycoprotein VI in a patient with a bleeding disorder [PDF]

Journal of Thrombosis and Haemostasis, 2009
The physiological relevance of the collagen glycoprotein VI (GPVI) receptor was known prior to its recognition as a platelet membrane receptor as several patients lacking GPVI as a consequence of autoantibody inhibition presented with a mild bleeding diathesis.
Hermans, C., Wittevrongel, C., Thys, Cindy, Smethurst, P.A., Van Geet, Christel, Freson, Kathleen   +5 more
openaire   +2 more sources

Hinokitiol is a novel glycoprotein VI antagonist on human platelets

Platelets, 2014
Hinokitiol (4-isopropyl-tropolone) is a bioactive compound with various pharmacological activities that is found in the wood of cupressaceous plants. Platelet activation plays an important role in thrombogenesis. In our previous study, hinokitiol specifically inhibited collagen-induced platelet aggregation ex vivo and prolonged thrombogenesis in vivo ...
Wan-Jung, Lu, Ming-Ping, Wu, Kuan-Hung, Lin, Yu-Chen, Lin, Hsiu-Chu, Chou, Joen-Rong, Sheu   +5 more
openaire   +2 more sources

Comparative Analysis of Microfluidics Thrombus Formation in Multiple Genetically Modified Mice: Link to Thrombosis and Hemostasis

Frontiers in Cardiovascular Medicine, 2019
Genetically modified mice are indispensable for establishing the roles of platelets in arterial thrombosis and hemostasis. Microfluidics assays using anticoagulated whole blood are commonly used as integrative proxy tests for platelet function in mice ...
Magdolna Nagy, Johanna P. van Geffen, David Stegner, David J. Adams, Attila Braun, Susanne M. de Witt, Margitta Elvers, Mitchell J. Geer, Marijke J. E. Kuijpers, Karl Kunzelmann, Jun Mori, Cécile Oury, Joachim Pircher, Irina Pleines, Alastair W. Poole, Yotis A. Senis, Remco Verdoold, Christian Weber, Christian Weber, Bernhard Nieswandt, Johan W. M. Heemskerk, Constance C. F. M. J. Baaten, Constance C. F. M. J. Baaten   +22 more
doaj   +1 more source

Effect of verapamil on systemic exposure and safety of umeclidinium and vilanterol: a randomized and open-label study

International Journal of COPD, 2013
Rashmi Mehta,1 Dennis Kelleher,1 Andrew Preece,2 Stephen Hughes,3 Glenn Crater4 1Respiratory Medicines Development Center, GlaxoSmithKline, Research Triangle Park, NC, USA; 2Respiratory Medicines Development Center, GlaxoSmithKline, Stockley Park West ...
Mehta R, Kelleher D, Preece A, Hughes S, Crater G   +4 more
doaj  

The role of Nox1 and Nox2 in GPVI-dependent platelet activation and thrombus formation

Redox Biology, 2014
Background: Activation of the platelet-specific collagen receptor, glycoprotein (GP) VI, induces intracellular reactive oxygen species (ROS) production; however the relevance of ROS to GPVI-mediated platelet responses remains unclear.
T.G. Walsh, M.C. Berndt, N. Carrim, J. Cowman, D. Kenny, P. Metharom   +5 more
doaj   +1 more source

ADPase CD39 Fused to Glycoprotein VI‐Fc Boosts Local Antithrombotic Effects at Vascular Lesions

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundGPVI (Glycoprotein VI) is the essential platelet collagen receptor in atherothrombosis. Dimeric GPVI‐Fc (Revacept) binds to GPVI binding sites on plaque collagen. As expected, it did not increase bleeding in clinical studies.
Heidrun Degen, Oliver Borst, Melanie Ziegler, Ann‐Katrin Mojica Munoz, Janina Jamasbi, Britta Walker, Silvia Göbel, Julia Fassbender, Kristin Adler, Richard Brandl, Götz Münch, Reinhard Lorenz, Wolfgang Siess, Meinrad Gawaz, Martin Ungerer   +14 more
doaj   +1 more source