Results 61 to 70 of about 43,195 (149)

Regulation and Function of WASp in Platelets by the Collagen Receptor, Glycoprotein VI

Blood, 1999
Wiskott Aldrich syndrome (WAS) is an X-linked recessive disorder associated with abnormalities in platelets and lymphocytes giving rise to thrombocytopenia and immunodeficiency. WAS is caused by a mutation in the gene encoding the cytoskeletal protein (WASp). Despite its importance, the role of WASp in platelet function is not established.
Gross, B, Wilde, J, Quek, L, Chapel, H, Nelson, D, Watson, S   +5 more
openaire   +3 more sources

Platelets modulate cardiac remodeling via the collagen receptor GPVI after acute myocardial infarction

Frontiers in Immunology
IntroductionPlatelets play an important role in cardiovascular diseases. After acute myocardial infarction, platelets display enhanced activation and migrate into the infarct zone.
Friedrich Reusswig, Matthias Dille, E. Krüger, J. Ortscheid, Tobias Feige, S. Gorressen, J.-W. Fischer, Margitta Elvers   +7 more
doaj   +1 more source

Platelet glycoprotein VI in the regulation of thrombus growth

, 2022
Platelet glycoprotein VI (GPVI) is the principal signalling receptor for collagen, which is exposed upon damage to the extracellular matrix and at site of rupture of an atherosclerotic plaque. GPVI has recently been shown to be also a receptor for fibrinogen and fibrin, which mediate platelet aggregation and clot formation.
openaire   +2 more sources

FcRγ‐chain signals in the absence of glycoprotein VI [PDF]

Journal of Thrombosis and Haemostasis, 2007
J, Liu, J, Ware, C W, Jackson, T K, Gartner   +3 more
openaire   +2 more sources

Distinct and Overlapping Metabolites Associated with Visual Impairment and Cognitive Impairment

Journal of Alzheimer's Disease Reports
Background: Previous studies found that visual impairment (VI) is associated with higher risk of cognitive impairment, but the molecular basis of these conditions is unknown.
Wenyi Hu, Tiancheng Chu, Huan Liao, Wei Wang, Jason Ha, Katerina Kiburg, Xiayin Zhang, Xianwen Shang, Yu Huang, Xueli Zhang, Shulin Tang, Yijun Hu, Honghua Yu, Xiaohong Yang, Mingguang He, Zhuoting Zhu   +15 more
doaj   +1 more source

Role of heat shock protein 47 in platelet glycoprotein VI dimerization and signaling. [PDF]

Res Pract Thromb Haemost, 2023
AlOuda SK, Sasikumar P, AlThunayan T, Alaajam F, Khan S, Sahli KA, Abohassan MS, Pollitt A, Jung SM, Gibbins JM.   +9 more
europepmc   +1 more source

Protease-activated receptors and glycoprotein VI cooperatively drive the platelet component in thromboelastography. [PDF]

J Thromb Haemost, 2023
Rudran T, Antoniak S, Flick MJ, Ginsberg MH, Wolberg AS, Bergmeier W, Lee RH.   +6 more
europepmc   +1 more source

Regulation of Glycoprotein VI-Dependent Platelet Activation and Thrombus Formation by Heparan Sulfate Proteoglycan Perlecan. [PDF]

Int J Mol Sci, 2023
Provenzale I, De Simone I, Gibbins JM, Heemskerk JWM, van der Meijden PEJ, Jones CI.   +5 more
europepmc   +1 more source

Multiparameter phenotyping of platelets and characterization of the effects of agonists using machine learning

Research and Practice in Thrombosis and Haemostasis
Background: Platelet function is driven by the expression of specialized surface markers. The concept of distinct circulating subpopulations of platelets has emerged in recent years, but their exact nature remains debatable.
Ami Vadgama, James Boot, Nicola Dark, Harriet E. Allan, Charles A. Mein, Paul C. Armstrong, Timothy D. Warner   +6 more
doaj   +1 more source

Platelet Receptor Glycoprotein VI-Dimer Is Overexpressed in Patients with Atrial Fibrillation at High Risk of Ischemic Stroke. [PDF]

TH Open, 2023
Induruwa I, Kempster C, Thomas P, McKinney H, Malcor JD, Bonna A, Batista J, Soejima K, Ouwehand W, Farndale RW, Downes K, Moroi M, Jung SM, Warburton EA.   +13 more
europepmc   +1 more source