Results 71 to 80 of about 43,195 (149)

Ultra-high throughput-based screening for the discovery of antiplatelet drugs affecting receptor dependent calcium signaling dynamics

Scientific Reports
Distinct platelet activation patterns are elicited by the tyrosine kinase-linked collagen receptor glycoprotein VI (GPVI) and the G-protein coupled protease-activated receptors (PAR1/4) for thrombin.
Delia I. Fernández, Sara Troitiño, Vladimír Sobota, Bibian M. E. Tullemans, Jinmi Zou, Helma van den Hurk, Ángel García, Saman Honarnejad, Marijke J. E. Kuijpers, Johan W. M. Heemskerk   +9 more
doaj   +1 more source

Introduction of an ancient founder glycoprotein VI mutation into the Chilean population. [PDF]

Blood Adv, 2022
Dalby A, Mezzano D, Miquel JF, Rivera J, Watson SP, Morgan NV.   +5 more
europepmc   +1 more source

Novel Ligands for Platelet Glycoprotein VI [PDF]

Thrombosis and Haemostasis, 2018
openaire   +2 more sources

Platelet glycoprotein VI as a mediator of metastasis [PDF]

Journal of Thrombosis and Haemostasis, 2009
openaire   +2 more sources

Nanobodies to GPVI as alternative reagents for platelet spreading

Platelets
Platelet spreading assays are widely used to assess platelet adhesion, cytoskeletal remodeling and receptor‑specific signaling, but current GPVI ligands such as Collagen Related Peptide (CRP‑XL) suffer from non‑defined structure, batch variability, and ...
Alexandre Slater, Hsin-Yun Pan, Tzu-Han Ho, Eleyna M. Martin, Stephen P. Watson, Jeremy A. Pike, Natalie S. Poulter, Steven G. Thomas   +7 more
doaj   +1 more source

Targeting Glycoprotein VI for Thromboembolic Disorders [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2019
Frederik Denorme, Matthew T. Rondina
openaire   +1 more source

Targeting GPVI as a novel antithrombotic strategy

Journal of Blood Medicine, 2014
Robert K Andrews, Jane F Arthur, Elizabeth E Gardiner Australian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia Abstract: While platelet activation is essential to maintain blood vessel patency and minimize loss of blood upon ...
Andrews RK, Arthur JF, Gardiner EE
doaj  

Platelet Rubicon Bidirectional Regulation of GPVI and Integrin αIIbβ3 Signaling Mitigates Stroke Infarction Without Compromising Hemostasis

Advanced Science
Inhibiting the platelet glycoprotein VI (GPVI) receptor is a promising strategy for reducing cerebral ischemia‐reperfusion injury (CIRI) without severe compromise of hemostasis, while targeting glycoprotein IIb/IIIa (integrin αIIbβ3) causes bleeding. The
Xiaoyan Chen, Jingke Li, Yangyang Liu, Li Li, Xin Deng, Yilin Sheng, Xianyu Zhu, Xiao Jiang, Wei Li, Xueli Cai, Qiming Sun, Hu Hu   +11 more
doaj   +1 more source

Modulation of Glycoprotein VI and Its Downstream Signaling Pathways as an Antiplatelet Target. [PDF]

Int J Mol Sci, 2022
Fuentes E.
europepmc   +1 more source

Platelet Activation by Antisense Oligonucleotides (ASOs) in the Göttingen Minipig, including an Evaluation of Glycoprotein VI (GPVI) and Platelet Factor 4 (PF4) Ontogeny. [PDF]

Pharmaceutics, 2023
Valenzuela A, Ayuso M, Buyssens L, Bars C, Van Ginneken C, Tessier Y, Van Cruchten S.   +6 more
europepmc   +1 more source