Results 91 to 100 of about 45,521 (251)

Distinct and Overlapping Metabolites Associated with Visual Impairment and Cognitive Impairment

Journal of Alzheimer's Disease Reports
Background: Previous studies found that visual impairment (VI) is associated with higher risk of cognitive impairment, but the molecular basis of these conditions is unknown.
Wenyi Hu, Tiancheng Chu, Huan Liao, Wei Wang, Jason Ha, Katerina Kiburg, Xiayin Zhang, Xianwen Shang, Yu Huang, Xueli Zhang, Shulin Tang, Yijun Hu, Honghua Yu, Xiaohong Yang, Mingguang He, Zhuoting Zhu   +15 more
doaj   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Role of heat shock protein 47 in platelet glycoprotein VI dimerization and signaling. [PDF]

Res Pract Thromb Haemost, 2023
AlOuda SK, Sasikumar P, AlThunayan T, Alaajam F, Khan S, Sahli KA, Abohassan MS, Pollitt A, Jung SM, Gibbins JM.   +9 more
europepmc   +1 more source

Metal–Organic Framework‐Preserved Thermostable Microneedle Patch for Minimally Invasive Detection and Monitoring of Kidney Dysfunction

Advanced Materials, EarlyView.
By growing a conformal ZIF‐8 protective layer directly on antibody‐functionalized microneedles, this work converts a fragile biosensing interface into a thermostable diagnostic platform. The MOF@MN patch enables minimally invasive NGAL detection from dermal ISF while supporting cold‐chain‐independent storage and transport for decentralized kidney ...
Yixuan Wang, Ying Liu, Avishek Debnath, Chuang Li, Zheyu Wang, Gayathri Kondepati, Saketh Balmoori, Jeremiah J. Morrissey, Ying Maggie Chen, Limei Tian, Srikanth Singamaneni   +10 more
wiley   +1 more source

Protease-activated receptors and glycoprotein VI cooperatively drive the platelet component in thromboelastography. [PDF]

J Thromb Haemost, 2023
Rudran T, Antoniak S, Flick MJ, Ginsberg MH, Wolberg AS, Bergmeier W, Lee RH.   +6 more
europepmc   +1 more source

Chaotropic Surface Arginine Correlates With Protein Corona Formation on Anti‐Fouling Biomaterial Surfaces: A Quantitative Proteomics and Protein Structure Study

Advanced Materials Interfaces, EarlyView.
Why do specific proteins accumulate on “non‐fouling” surfaces? Quantitative proteomics and structural analysis reveal surface‐exposed arginine as the key molecular determinant. ABSTRACT The protein corona determines the biocompatibility of medical devices, yet predicting its composition on anti‐fouling surfaces remains challenging.
Ayano Nomura, Guanghao Hu, Ang Art Wei Yao, Chisato Komura, Hideharu Kurioka, Tomohiro Hayashi   +5 more
wiley   +1 more source

At Home Detection of Ovarian Health Biomarker in Menstruation Blood

Advanced Materials Technologies, EarlyView.
A lateral flow assay enables the detection of anti‐Müllerian hormone directly in unprocessed menstrual blood using silica‐gold nanoshells and smartphone‐assisted machine learning analysis. The platform supports decentralized, user‐operated testing in wearable and dipstick formats, highlighting the potential of menstrual blood as a non‐invasive matrix ...
Lucas Dosnon, Thomas Rduch, Salma Sherif Azer, Inge K. Herrmann   +3 more
wiley   +1 more source

Chemoproteomic Identification of AKT2 as a Paclitaxel‐Binding Protein via C─C Bond‐Linked Probe PTX‐4 in Paclitaxel‐Resistant Breast Cancer

Advanced Science, EarlyView.
ABSTRACT Breast cancer remains one of the most prevalent malignancies among women, and taxane‐based chemotherapies such as paclitaxel and docetaxel are central to standard treatment regimens. However, drug resistance in breast cancer limits therapeutic efficacy and contributes to recurrence and metastasis.
Kai Wang, Yuqing Yuan, Wei Shen, Xiuxiu Yang, Xiaokang Wu, Haihua Zhou, Yi Hu, Qing Zhu   +7 more
wiley   +1 more source

Multiparameter phenotyping of platelets and characterization of the effects of agonists using machine learning

Research and Practice in Thrombosis and Haemostasis
Background: Platelet function is driven by the expression of specialized surface markers. The concept of distinct circulating subpopulations of platelets has emerged in recent years, but their exact nature remains debatable.
Ami Vadgama, James Boot, Nicola Dark, Harriet E. Allan, Charles A. Mein, Paul C. Armstrong, Timothy D. Warner   +6 more
doaj   +1 more source

Regulation of Glycoprotein VI-Dependent Platelet Activation and Thrombus Formation by Heparan Sulfate Proteoglycan Perlecan. [PDF]

Int J Mol Sci, 2023
Provenzale I, De Simone I, Gibbins JM, Heemskerk JWM, van der Meijden PEJ, Jones CI.   +5 more
europepmc   +1 more source