Results 1 to 10 of about 289 (70)
Myricetin as a promising inhibitor of platelet fibrinogen receptor in humans
Heliyon, 2023 Platelets play a vital role in the formation of dangerous arterial thrombosis. Platelets are activated by adhesive proteins or soluble agonists through their specific receptors.
Yi Chang +7 more
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Kindlins, integrin activation and the regulation of talin recruitment to αIIbβ3. [PDF]
PLoS ONE, 2012 Talins and kindlins bind to the integrin β3 cytoplasmic tail and both are required for effective activation of integrin αIIbβ3 and resulting high-affinity ligand binding in platelets. However, binding of the talin head domain alone to β3 is sufficient to
Bryan N Kahner +5 more
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The WASH-complex subunit Strumpellin regulates integrin αIIbβ3 trafficking in murine platelets
Scientific Reports, 2023 The platelet specific integrin αIIbβ3 mediates platelet adhesion, aggregation and plays a central role in thrombosis and hemostasis. In resting platelets, αIIbβ3 is expressed on the membrane surface and in intracellular compartments. Upon activation, the
Yvonne Schurr +5 more
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Cryo-EM structures of full-length integrin αIIbβ3 in native lipids
Nature Communications, 2023 Platelet integrin αIIbβ3 is maintained in a bent inactive state (low affinity to physiologic ligand), but can rapidly switch to a ligand-competent (high-affinity) state in response to intracellular signals (“inside-out” activation).
Brian D. Adair +3 more
doaj +1 more source
Molecular Oncology, 2021 Cadherin 6 (CDH6) is significantly overexpressed in advanced ovarian and renal cancers. However, the role of CDH6 in cancer metastasis is largely unclear.
Rubén A. Bartolomé +8 more
doaj +1 more source
Cells, 2023 CD40L is expressed in activated T cells, and it plays a major role in immune response and is a major therapeutic target for inflammation. High IgM syndrome type 1 (HIGM1) is a congenital functional defect in CD40L/CD40 signaling due to defective CD40L ...
Yoko K. Takada +2 more
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Membranes, 2021 The study of the platelet receptor integrin αIIbβ3 in a membrane-mimetic environment without interfering signalling pathways is crucial to understand protein structure and dynamics.
Una Janke +4 more
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Platelet integrin αIIbβ3: signal transduction, regulation, and its therapeutic targeting
Journal of Hematology & Oncology, 2019 Integrins are a family of transmembrane glycoprotein signaling receptors that can transmit bioinformation bidirectionally across the plasma membrane.
Jiansong Huang +17 more
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Platelets, 2020 Phosphatidylinositol 3 kinase (PI3K) is a major player in platelet activation and regulates thrombus formation and stabilization. The β isoform of PI3K is implicated in integrin αIIbβ3 outside-in signaling, is required for the phosphorylation of Akt, and
Mauro Torti +7 more
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Cells, 2022 Activation of platelet integrin αIIbβ3, a key event for hemostasis and thrombus formation, is known to be mediated exclusively by inside-out signaling. We showed that inflammatory chemokines CX3CL1 and CXCL12 in previous studies, and CCL5 in this study ...
Yoko K. Takada +2 more
doaj +1 more source