Results 1 to 10 of about 7,566 (100)
Cells, 2023 CD40L is expressed in activated T cells, and it plays a major role in immune response and is a major therapeutic target for inflammation. High IgM syndrome type 1 (HIGM1) is a congenital functional defect in CD40L/CD40 signaling due to defective CD40L ...
Yoko K. Takada +2 more
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Cells, 2022 Activation of platelet integrin αIIbβ3, a key event for hemostasis and thrombus formation, is known to be mediated exclusively by inside-out signaling. We showed that inflammatory chemokines CX3CL1 and CXCL12 in previous studies, and CCL5 in this study ...
Yoko K. Takada +2 more
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The enigmatic nature of the triggering receptor expressed in myeloid cells -1 (TLT- 1)
Platelets, 2021 Receptors are important pharmacological targets on cells. The Triggering Receptor Expressed on Myeloid Cells (TREM) – Like Transcript – 1 is an abundant, yet little understood, platelet receptor.
Siobhan Branfield, A. Valance Washington
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Activated αIIbβ3 on platelets mediates flow-dependent NETosis via SLC44A2
eLife, 2020 Platelet-neutrophil interactions are important for innate immunity, but also contribute to the pathogenesis of deep vein thrombosis, myocardial infarction and stroke.
Adela Constantinescu-Bercu +5 more
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Platelets, 2021 Fucosylated glycosaminoglycan (FG) from sea cucumbers has been reported to have anticoagulant effects via targeting intrinsic tenase. However, FG from natural source also potentially poses risks due to its FXIIa activation and platelet aggregating ...
Lisha Lin +6 more
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Volatile anesthetics, not intravenous anesthetic propofol bind to and attenuate the activation of platelet receptor integrin αIIbβ3. [PDF]
PLoS ONE, 2013 In clinical reports, the usage of isoflurane and sevoflurane was associated with more surgical field bleeding in endoscopic sinus surgeries as compared to propofol.
Koichi Yuki +3 more
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Structure, signal transduction, activation, and inhibition of integrin αIIbβ3
Thrombosis Journal, 2023 Integrins are heterodimeric receptors comprising α and β subunits. They are expressed on the cell surface and play key roles in cell adhesion, migration, and growth. Several types of integrins are expressed on the platelets, including αvβ3, αIIbβ3, α2β1,
Honglei Xin +5 more
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The WASH-complex subunit Strumpellin regulates integrin αIIbβ3 trafficking in murine platelets
Scientific Reports, 2023 The platelet specific integrin αIIbβ3 mediates platelet adhesion, aggregation and plays a central role in thrombosis and hemostasis. In resting platelets, αIIbβ3 is expressed on the membrane surface and in intracellular compartments. Upon activation, the
Yvonne Schurr +5 more
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Molecular Oncology, 2021 Cadherin 6 (CDH6) is significantly overexpressed in advanced ovarian and renal cancers. However, the role of CDH6 in cancer metastasis is largely unclear.
Rubén A. Bartolomé +8 more
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Kindlins, integrin activation and the regulation of talin recruitment to αIIbβ3. [PDF]
PLoS ONE, 2012 Talins and kindlins bind to the integrin β3 cytoplasmic tail and both are required for effective activation of integrin αIIbβ3 and resulting high-affinity ligand binding in platelets. However, binding of the talin head domain alone to β3 is sufficient to
Bryan N Kahner +5 more
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