Results 41 to 50 of about 9,490 (159)

Targeting the CD47–SIRPα phagocytic checkpoint in cancer: Biology, translational opportunities, and next‐generation therapeutic strategies

Smart Molecules, EarlyView.
The CD47–SIRPα axis has emerged as a critical innate immune checkpoint that suppresses macrophage‐mediated phagocytosis through a canonical “don't eat me” signal and enables tumor immune evasion. We comprehensively summarize the structural and biological features of CD47 and the molecular mechanisms underlying CD47‐mediated regulation of phagocytosis ...
Ruimei Zhou, Lingjie Jing, Jianping Zhang, Cheng Guo, Quanjun Yang   +4 more
wiley   +1 more source

Coated platelets function in platelet-dependent fibrin formation via integrin αIIbβ3 and transglutaminase factor XIII

Haematologica, 2016
Coated platelets, formed by collagen and thrombin activation, have been characterized in different ways: i) by the formation of a protein coat of α-granular proteins; ii) by exposure of procoagulant phosphatidylserine; or iii) by high fibrinogen binding.
Nadine J.A. Mattheij, Frauke Swieringa, Tom G. Mastenbroek, Michelle A. Berny-Lang, Frauke May, Constance C.F.M.J. Baaten, Paola E.J. van der Meijden, Yvonne M.C. Henskens, Erik A.M. Beckers, Dennis P.L. Suylen, Marc W. Nolte, Tilman M. Hackeng, Owen J.T. McCarty, Johan W.M. Heemskerk, Judith M.E.M. Cosemans   +14 more
doaj   +1 more source

Distinct Domains of αIIbβ3 Support Different Aspects of Outside-In Signal Transduction and Platelet Activation Induced by LSARLAF, an αIIbβ3 Interacting Peptide

, 2001
SummaryThe peptide LSARLAF causes αIIbβ3-dependent platelet activation exemplified by secretion, aggregation, spreading and adhesion on fibrinogen, and tyrosine phosphorylation.
Sanford Shattil, Ralph Gruppo, Jerry Derrick, Mortimer Poncz, Kent Gartner   +4 more
core   +1 more source

CIB1 is an endogenous inhibitor of agonist-induced integrin αIIbβ3 activation [PDF]

, 2006
In response to agonist stimulation, the αIIbβ3 integrin on platelets is converted to an active conformation that binds fibrinogen and mediates platelet aggregation. This process contributes to both normal hemostasis and thrombosis.
Yuan, Weiping, McFadden, Andrew W., Clark, Shantres, Lam, Stephen C.T., Shantres Clark, Leslie V. Parise, Christel Boudignon-Proudhon, Parise, Leslie V., Tina M. Leisner, Boudignon-Proudhon, Christel, Zhengyan Wang, Stephen C.-T. Lam, Wang, Zhengyan, Andrew W. McFadden, Larson, Mark K., Mark K. Larson, Weiping Yuan, Leisner, Tina M.   +17 more
core   +1 more source

Evolutionary Mechanisms of Coagulation Factors in Cetaceans During Aquatic Adaptation

Integrative Zoology, EarlyView.
Compared with Bos taurus, T. truncatus showed shorter prothrombin time and thrombin time but prolonged activated partial thromboplastin time, indicating pathway‐specific remodeling of coagulation. Evolutionary analyses identified 18 positively selected genes and accelerated F11 evolution, while functional assays revealed increased coagulation factor ...
Wenjun Lv, Wanfei Deng, Fei Deng, Shixia Xu, Wenhua Ren   +4 more
wiley   +1 more source

The pivotal role of von Willebrand factor binding to platelet αIIbβ3 in stabilizing the formation of a platelet plug at sites of injury

Haematologica
The interaction between VWF and platelet αIIbβ3 is thought to be essential for clot formation at injury sites, but its biological properties remain poorly understood due to the complexity and overlap with other αIIbβ3 ligands. Here, we developed a novel
Qizhen Shi, Jeremy G. Mattson, Patricia A. Morateck, Pamela A. Christopherson, Jocelyn A. Schroeder, Scot A. Fahs, Jessica Rapten, Marie L. Schulte, Hartmut Weiler, Jieqing Zhu, Sandra L. Haberichter, Veronica H. Flood, Robert R. Montgomery   +12 more
doaj   +1 more source

Molecular dynamics analysis of a novel β3 Pro189Ser mutation in a patient with glanzmann thrombasthenia differentially affecting αIIbβ3 and αvβ3 expression.

PLoS ONE, 2013
Mutations in ITGA2B and ITGB3 cause Glanzmann thrombasthenia, an inherited bleeding disorder in which platelets fail to aggregate when stimulated.
Michel Laguerre, Essa Sabi, Martina Daly, Jacqueline Stockley, Paquita Nurden, Xavier Pillois, Alan T Nurden   +6 more
doaj   +1 more source

Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin αIIbβ3 and Lyn Kinase. [PDF]

PLoS ONE, 2015
IgG immune complexes contribute to the etiology and pathogenesis of numerous autoimmune disorders, including heparin-induced thrombocytopenia, systemic lupus erythematosus, rheumatoid- and collagen-induced arthritis, and chronic glomerulonephritis ...
Huiying Zhi, Jing Dai, Junling Liu, Jieqing Zhu, Debra K Newman, Cunji Gao, Peter J Newman   +6 more
doaj   +1 more source

Integrin αIIbβ3 regulation in platelets [PDF]

, 2006
In summary, the studies described in this thesis show that discrete parts of the platelet integrin αIIbβ3 are involved in discrete ligand binding sub processes. A tripeptide sequence in the A3 domain of vWF is involved in preactivation of αIIbβ3, leading
Litjens, P.E.M.H.
core  

Outside-in signaling mediated by αIIb in CHO cells expressing αIIbβ3.

, 2012
(A) Spreading of CHO cells expressing αIIbβ3-WT, αIIbβ3-scramble and αIIbβ3-Δ724, respectively on immobilized Fg for 90minutes. (B) Quantification of area (pixel number) in 4 random fields (mean±SE) at all 6 time points.
Weiran Chai (127898), Yanhua Wang (127897), Kemin Wang (9691), Xue Chen (127892), Haixia Niu (127891), Lin Zhang (8926), Zhongren Ding (127901), T. Kent Gartner (127903), Junling Liu (127905), Ralph A. Gruppo (127894), Yueping Sun (127900), Ding Li (127896)   +11 more
core   +1 more source