Results 21 to 30 of about 9,490 (159)

Dynamic Regulation of Fibrinogen: Integrin αIIbβ3 Binding [PDF]

, 2010
This study demonstrates that two orthogonal events regulate integrin αIIbβ3’s interactions with fibrinogen, its primary physiological ligand: (1) conformational changes at the αIIb–β3 interface and (2) flexibility in the carboxy terminus of fibrinogen’s ...
Lord, Susan T., Susan T. Lord, Mary C. Stahle, Stahle, Mary C., Roy R. Hantgan, Hantgan, Roy R.   +5 more
core   +1 more source

New insights into regulation of αIIbβ3 integrin signaling by filamin A

Research and Practice in Thrombosis and Haemostasis, 2022
Background Filamin (FLN) regulates many cell functions through its scaffolding activity cross‐linking cytoskeleton and integrins. FLN was shown to inhibit integrin activity, but the exact mechanism remains unclear. Objectives The aim of this study was to
Lamia Lamrani, Frédéric Adam, Christelle Soukaseum, Cécile V. Denis, Hana Raslova, Jean‐Philippe Rosa, Marijke Bryckaert   +6 more
doaj   +1 more source

Clathrin-mediated integrin αIIbβ3 trafficking controls platelet spreading

Platelets, 2018
Dynamic endocytic and exocytic trafficking of integrins is an important mechanism for cell migration, invasion, and cytokinesis. Endocytosis of integrin can be classified as clathrin dependent and clathrin independent manners.
Wen Gao, Panlai Shi, Xue Chen, Lin Zhang, Junling Liu, Xuemei Fan, Xinping Luo   +6 more
doaj   +1 more source

Glanzmann Thrombasthenia: Perspectives from Clinical Practice on Accurate Diagnosis and Optimal Treatment Strategies

Journal of Blood Medicine, 2021
Natalie Mathews,1 Georges-Etienne Rivard,2 Arnaud Bonnefoy2 1Division of Haematology/Oncology, Department of Paediatrics, The Hospital for Sick Children, Toronto, Ontario, Canada; 2Division of Hematology-Oncology, Department of Pediatrics, CHU Sainte ...
Mathews N, Rivard GE, Bonnefoy A
doaj  

L718P mutation in the membrane-proximal cytoplasmic tail of β3 promotes abnormal αIIbβ3 clustering and lipid microdomain coalescence, and associates with a thrombasthenia-like phenotype

Haematologica, 2010
Background Support for the role of transmembrane and membrane-proximal domains of αIIbβ3 integrin in the maintenance of receptor low affinity comes from mutational studies showing that activating mutations can induce constitutive bi-directional ...
Asier Jayo, Isabel Conde, Pedro Lastres, Constantino Martínez, José Rivera, Vicente Vicente, Consuelo González-Manchón   +6 more
doaj   +1 more source

Variation in One Residue Associated with the Metal Ion- Dependent Adhesion Site Regulates αIIbβ3 IntegrinLigand Binding Affinity [PDF]

, 2013
Variation in One Residue Associated with the Metal Ion- Dependent Adhesion Site Regulates αIIbβ3 IntegrinLigand Binding ...
, Joel Raborn, 李国辉, 付婷, Bing-Hao Luo, Zhilong Xiu, 吴雪, Zhilong Xiu (468058), Luo, Bing Hao, Wu, Xue, Xue Wu (317735), Luo Bing-Hao, Guohui Li (105239), Fu Ting, Li Guohui, Raborn, Joel, Raborn Joel, Bing-Hao Luo (3810), Ting Fu (468057), Xiu, Zhilong, Li, Guohui, Joel Raborn (468056), Wu Xue, Guohui Li, Ting Fu, Xiu Zhilong, Fu, Ting, Luo, Bing-Hao, Xue Wu   +28 more
core   +2 more sources

Dynamic Regulation of Fibrinogen: Integrin αIIbβ3 Binding

, 2016
This study demonstrates that two orthogonal events regulate integrin αIIbβ3's interactions with fibrinogen, its primary physiological ligand: (1) conformational changes at the αIIb−β3 interface and (2) flexibility in the carboxy terminus of fibrinogen’s ...
Mary C. Stahle (2255554), Roy R. Hantgan (202202), Susan T. Lord (1346931)   +2 more
core   +1 more source

USP15-Mediated Deubiquitination of FKBP 5 and Activation of the αIIbβ3 Signaling Pathway Regulate Thrombosis in Mice

Frontiers in Bioscience-Landmark
Background: Platelets have the hemostatic function, and their aberrant activation is associated with occlusive thrombus formation. Plasma exosomes are rich in platelets containing ubiquitin-specific peptidase 15 (USP15). Herein, we aim
Ziwei Guo, Sixu Bao, Zehui Shi, Xuejiao Li, Peijin Li, Bin Zhong, Ming Zhang, Qiyong Wu   +7 more
doaj   +1 more source

Restoration of responsiveness of phospholipase Cγ2-deficient platelets by enforced expression of phospholipase Cγ1. [PDF]

PLoS ONE, 2015
Receptor-mediated platelet activation requires phospholipase C (PLC) activity to elevate intracellular calcium and induce actin cytoskeleton reorganization. PLCs are classified into structurally distinct β, γ, δ, ε, ζ, and η isoforms.
Yongwei Zheng, Tamara Adams, Huiying Zhi, Mei Yu, Renren Wen, Peter J Newman, Demin Wang, Debra K Newman   +7 more
doaj   +1 more source

Myricetin as a promising inhibitor of platelet fibrinogen receptor in humans

Heliyon, 2023
Platelets play a vital role in the formation of dangerous arterial thrombosis. Platelets are activated by adhesive proteins or soluble agonists through their specific receptors.
Yi Chang, Chih-Wei Hsia, Wei-Chieh Huang, Thanasekaran Jayakumar, Chih-Hsuan Hsia, Ting-Lin Yen, Joen-Rong Sheu, Shaw-Min Hou   +7 more
doaj   +1 more source