Results 21 to 30 of about 62,112 (126)

Integrin αIIbβ3: from platelet membrane to biomimetic models [PDF]

, 2016
The cell membrane is complex mixture of phospholipids, sphingolipids, sterols and proteins that combine to provide a semi-permeable barrier between the extracellular and intracellular environments, while also providing a functional role in cell ...
Gaul, Vincent
core   +2 more sources

CIB1 is an endogenous inhibitor of agonist-induced integrin αIIbβ3 activation [PDF]

, 2006
In response to agonist stimulation, the αIIbβ3 integrin on platelets is converted to an active conformation that binds fibrinogen and mediates platelet aggregation. This process contributes to both normal hemostasis and thrombosis.
Yuan, Weiping, McFadden, Andrew W., Clark, Shantres, Lam, Stephen C.T., Shantres Clark, Leslie V. Parise, Christel Boudignon-Proudhon, Parise, Leslie V., Tina M. Leisner, Boudignon-Proudhon, Christel, Zhengyan Wang, Stephen C.-T. Lam, Wang, Zhengyan, Andrew W. McFadden, Larson, Mark K., Mark K. Larson, Weiping Yuan, Leisner, Tina M.   +17 more
core   +1 more source

Apolipoprotein A-IV binds αIIbβ3 integrin and inhibits thrombosis

Nature Communications, 2018
Activation of integrin αIIbβ3 at the surface of platelets is required for their aggregation and for thrombus formation. Here Xu et al. identify apolipoprotein A-IV as a novel ligand for platelet αIIbβ3 integrin, and find it inhibits platelet aggregation ...
Xiaohong Ruby Xu, Yiming Wang, Reheman Adili, Lining Ju, Christopher M. Spring, Joseph Wuxun Jin, Hong Yang, Miguel A. D. Neves, Pingguo Chen, Yan Yang, Xi Lei, Yunfeng Chen, Reid C. Gallant, Miao Xu, Hailong Zhang, Jina Song, Peifeng Ke, Dan Zhang, Naadiya Carrim, Si-Yang Yu, Guangheng Zhu, Yi-Min She, Terry Cyr, Wenbin Fu, Guoqing Liu, Philip W. Connelly, Margaret L. Rand, Khosrow Adeli, John Freedman, Jeffrey E. Lee, Patrick Tso, Patrizia Marchese, W. Sean Davidson, Shaun P. Jackson, Cheng Zhu, Zaverio M. Ruggeri, Heyu Ni   +36 more
doaj   +1 more source

Implications of the differing roles of the β1 and β3 transmembrane and cytoplasmic domains for integrin function

eLife, 2016
Integrins are transmembrane receptors composed of α and β subunits. Although most integrins contain β1, canonical activation mechanisms are based on studies of the platelet integrin, αIIbβ3.
Zhenwei Lu, Sijo Mathew, Jiang Chen, Arina Hadziselimovic, Riya Palamuttam, Billy G Hudson, Reinhard Fässler, Ambra Pozzi, Charles R Sanders, Roy Zent   +9 more
doaj   +1 more source

Coated platelets function in platelet-dependent fibrin formation via integrin αIIbβ3 and transglutaminase factor XIII

Haematologica, 2016
Coated platelets, formed by collagen and thrombin activation, have been characterized in different ways: i) by the formation of a protein coat of α-granular proteins; ii) by exposure of procoagulant phosphatidylserine; or iii) by high fibrinogen binding.
Nadine J.A. Mattheij, Frauke Swieringa, Tom G. Mastenbroek, Michelle A. Berny-Lang, Frauke May, Constance C.F.M.J. Baaten, Paola E.J. van der Meijden, Yvonne M.C. Henskens, Erik A.M. Beckers, Dennis P.L. Suylen, Marc W. Nolte, Tilman M. Hackeng, Owen J.T. McCarty, Johan W.M. Heemskerk, Judith M.E.M. Cosemans   +14 more
doaj   +1 more source

The photolabeled residues of integrin αIIbβ3 by azi-isoflurane.

, 2013
The photolabeled residues of integrin αIIbβ3 by azi-isoflurane.
Koichi Yuki (398264), Weiming Bu (184333), Motomu Shimaoka (398265), Roderic Eckenhoff (398266)   +3 more
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Strong Binding of Platelet Integrin αIIbβ3 to Fibrin Clots: Potential Target to Destabilize Thrombi [PDF]

, 2017
The formation of platelet thrombi is determined by the integrin αIIbβ3-mediated interactions of platelets with fibrinogen and fibrin. Blood clotting in vivo is catalyzed by thrombin, which simultaneously induces fibrinogen binding to αIIbβ3 and converts ...
Mark S. Alber, Zhiliang Xu, Weisel, John W, Weisel, John W., Kim, Oleg V., Shixin Xu, John W. Weisel, Oleg V. Kim, Bennett, Joel S, Xu, Shixin, Litvinov, Rustem I., Litvinov, Rustem I, Kim, Oleg V, Xu, Zhiliang, Peter Höök, Joel S. Bennett, Alber, Mark S, Alber, Mark S., Höök, Peter, Rustem I. Litvinov, Bennett, Joel S.   +20 more
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Reconstructing and Deconstructing Agonist-Induced Activation of Integrin αIIbβ3

, 2006
SummaryBackgroundIntegrin receptors, composed of transmembrane α and β subunits, are essential for the development and functioning of multicellular animals.
Ginsberg, Mark H., Watanabe, Naohide, Shattil, Sanford J., Ratnikov, Boris, Boussiotis, Vassiliki A., Han, Jaewon, Lim, Chinten James, Puzon-McLaughlin, Wilma, Soriani, Alessandra, Lafuente, Esther M., Calderwood, David A.   +10 more
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Dynamic Regulation of Fibrinogen: Integrin αIIbβ3 Binding [PDF]

, 2010
This study demonstrates that two orthogonal events regulate integrin αIIbβ3’s interactions with fibrinogen, its primary physiological ligand: (1) conformational changes at the αIIb–β3 interface and (2) flexibility in the carboxy terminus of fibrinogen’s ...
Lord, Susan T., Susan T. Lord, Mary C. Stahle, Stahle, Mary C., Roy R. Hantgan, Hantgan, Roy R.   +5 more
core   +1 more source

Roles of Focal Adhesion Kinase PTK2 and Integrin αIIbβ3 Signaling in Collagen- and GPVI-Dependent Thrombus Formation under Shear [PDF]

, 2022
Glycoprotein (GP)VI and integrin αIIbβ3 are key signaling receptors in collagen-dependent platelet aggregation and in arterial thrombus formation under shear. The multiple downstream signaling pathways are still poorly understood.
Wichapong, Kanin, Huang, Jingnan, Ángel García, Kanin Wichapong, Heemskerk, Johan W. M., Dijkgraaf, Ingrid, Albert Sickmann, Ingrid Dijkgraaf, Fernández, Delia I, Jingnan Huang, Sickmann, Albert, Jooss, Natalie J, Natalie J. Jooss, Wichapong, Kanin; id_orcid, Johan W. M. Heemskerk, Jooss, Natalie J., Fernández, Delia I., Dijkgraaf, Ingrid; id_orcid, Delia I. Fernández, Heemskerk, Johan W M, García, Ángel, García Alonso, Ángel, Fernández, D.I., Heemskerk, J.W.M., Dijkgraaf, I., Sickmann, A., Jooss, N.J., Wichapong, K., Huang, J.   +28 more
core   +2 more sources