Clathrin-mediated integrin αIIbβ3 trafficking controls platelet spreading
Platelets, 2018 Dynamic endocytic and exocytic trafficking of integrins is an important mechanism for cell migration, invasion, and cytokinesis. Endocytosis of integrin can be classified as clathrin dependent and clathrin independent manners.
Wen Gao +6 more
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Volatile anesthetics, not intravenous anesthetic propofol bind to and attenuate the activation of platelet receptor integrin αIIbβ3. [PDF]
PLoS ONE, 2013 In clinical reports, the usage of isoflurane and sevoflurane was associated with more surgical field bleeding in endoscopic sinus surgeries as compared to propofol.
Koichi Yuki +3 more
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Hypoxia impairs agonist-induced integrin αIIbβ3 activation and platelet aggregation [PDF]
Scientific Reports, 2017 Under ischemic conditions, tissues are exposed to hypoxia. Although human physiology, to a certain extent, can adapt to hypoxic conditions, the impact of low oxygen levels on platelet function is unresolved.
Klytaimnistra Kiouptsi +5 more
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The integrin-linked kinase-PINCH-parvin complex supports integrin αIIbβ3 activation.
PLoS ONE, 2013 Integrin-linked kinase (ILK) is an important signaling regulator that assembles into the heteroternary complex with adaptor proteins PINCH and parvin (termed the IPP complex).
Shigenori Honda +4 more
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Structure, signal transduction, activation, and inhibition of integrin αIIbβ3
Thrombosis Journal, 2023 Integrins are heterodimeric receptors comprising α and β subunits. They are expressed on the cell surface and play key roles in cell adhesion, migration, and growth. Several types of integrins are expressed on the platelets, including αvβ3, αIIbβ3, α2β1,
Honglei Xin +5 more
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Mechanistic Basis for the Binding of RGD- and AGDV-Peptides to the Platelet Integrin αIIbβ3 [PDF]
, 2017 © 2017 American Chemical Society.Binding of soluble fibrinogen to the activated conformation of the integrin αIIbβ3 is required for platelet aggregation and is mediated exclusively by the C-terminal AGDV-containing dodecapeptide (γC-12) sequence of the ...
Weisel J. +6 more
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Effects of the RGD loop and C-terminus of rhodostomin on regulating integrin αIIbβ3 recognition. [PDF]
PLoS ONE, 2017 Rhodostomin (Rho) is a medium disintegrin containing a 48PRGDMP motif. We here showed that Rho proteins with P48A, M52W, and P53N mutations can selectively inhibit integrin αIIbβ3. To study the roles of the RGD loop and C-terminal region in disintegrins,
Yao-Tsung Chang +6 more
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Haematologica, 2010 Background Support for the role of transmembrane and membrane-proximal domains of αIIbβ3 integrin in the maintenance of receptor low affinity comes from mutational studies showing that activating mutations can induce constitutive bi-directional ...
Asier Jayo +6 more
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Normal Platelet Integrin Function in Mice Lacking Hydrogen Peroxide-Induced Clone-5 (Hic-5).
PLoS ONE, 2015 Integrin αIIbβ3 plays a central role in the adhesion and aggregation of platelets and thus is essential for hemostasis and thrombosis. Integrin activation requires the transmission of a signal from the small cytoplasmic tails of the α or β subunit to the
Michael Popp +3 more
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Inhibition of αIIbβ3 Ligand Binding by an αIIb Peptide that Clasps the Hybrid Domain to the βI Domain of β3. [PDF]
PLoS ONE, 2015 Agonist-stimulated platelet activation triggers conformational changes of integrin αIIbβ3, allowing fibrinogen binding and platelet aggregation. We have previously shown that an octapeptide, p1YMESRADR8, corresponding to amino acids 313-320 of the β ...
Wen Hwa Lee +10 more
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