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Deciphering glycoprotein VI signalling in platelet activation

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Glycoprotein VI - novel target in antiplatelet medication

Pharmacology & Therapeutics, 2021
Subendothelial collagen exposed to platelets after rupture of atherosclerotic plaques is the main trigger of platelet activation und acute arterial thrombotic occlusion leading to myocardial infarction or ischemic stroke. An efficacious antiplatelet therapy is essential to prevent atherothrombotic events.
Oliver, Borst, Meinrad, Gawaz
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Focusing on plasma glycoprotein VI

Thrombosis and Haemostasis, 2012
SummaryNew methods for analysing both platelet and plasma forms of the platelet-specific collagen receptor, glycoprotein VI (GPVI) in experimental models or human clinical samples, and the development of the first therapeutic compounds based on dimeric soluble GPVI-Fc or anti-GPVI antibody-based constructs, coincide with increased understanding of the ...
M, Al-Tamimi, J F, Arthur, E, Gardiner, R K, Andrews   +3 more
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Implications of glycoprotein VI for theranostics

Thrombosis and Haemostasis, 2014
SummaryGlycoprotein VI (GPVI), a membrane glycoprotein solely expressed in platelets and megakaryocytes, plays a critical role in thrombus formation due to collagen/GPVI-mediated platelet activation and adhesion. Recent studies have shown that surface expression of GPVI on circulating platelets is enhanced in acute cardiovascular diseases such as ...
M, Gawaz, S, Vogel, C, Pfannenberg, B, Pichler, H, Langer, B, Bigalke   +5 more
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Platelet Glycoprotein VI

2008
Glycoprotein VI (GPVI) is a membrane glycoprotein unique to platelets and has been identified as a physiological receptor for collagen. Damage to a vessel wall exposes the subendothelial component collagen to platelets in the blood flow. Interaction of platelets with collagen via the receptor GPVI results in platelet activation and adhesion--the ...
Stephanie M, Jung, Masaaki, Moroi
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Dimeric Glycoprotein VI Binds to Collagen but Not to Fibrin

Thrombosis and Haemostasis, 2018
AbstractPlatelet glycoprotein VI (GPVI) acts as a decisive collagen receptor in atherothrombosis. Besides collagen, injured atherosclerotic plaques expose tissue factor (TF) that triggers fibrin formation. Two recent studies reported that platelet GPVI also functions as fibrin receptor, which would importantly widen the mode of action of GPVI-targeted ...
Ebrahim, Mariam, Jamasbi, Janina, Adler, Kristin, Megens, Remco T. A., M'Bengue, Yacine, Blanchet, Xavier, Uhland, Kerstin, Ungerer, Martin, Brandl, Richard, Weber, Christian, Elia, Natalie, Lorenz, Reinhard, Muench, Goetz, Siess, Wolfgang   +13 more
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Platelet glycoprotein VI: its structure and function

Thrombosis Research, 2004
Glycoprotein (GP) VI is a platelet membrane protein with a molecular weight of 62 kDa that was identified as a physiological collagen receptor from studies of patients deficient in this protein. GPVI-deficient platelets lacked specifically collagen-induced aggregation and the ability to form thrombi on a collagen surface under flow conditions ...
Masaaki, Moroi, Stephanie M, Jung
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Diagnostic and Therapeutic Potentials of Platelet Glycoprotein VI

Seminars in Thrombosis and Hemostasis, 2010
Platelets respond immediately to vascular injury by adhesion, aggregation, and thrombus formation. Disruption of the endothelial cell layer exposes extracellular matrix to the bloodstream. Collagen binding to platelet glycoprotein VI (GPVI) mediates the initial adhesion of the rolling platelet to the vascular wound. Signaling by GPVI leads to the onset
Boris, Bigalke, Björn F, Krämer, Peter, Seizer, Suzanne, Fateh-Moghadam, Meinrad, Gawaz, Stephan, Lindemann   +5 more
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Progress toward a Glycoprotein VI Modulator for the Treatment of Thrombosis

Journal of Medicinal Chemistry, 2020
Pathogenic thrombus formation accounts for the etiology of many serious conditions including myocardial infarction, stroke, deep vein thrombosis, and pulmonary embolism. Despite the development of numerous anticoagulants and antiplatelet agents, the mortality rate associated with these diseases remains high.
Foster, H, Wilson, C, Philippou, H, Foster, R   +3 more
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Platelet Receptor Expression and Shedding: Glycoprotein Ib-IX-V and Glycoprotein VI

Transfusion Medicine Reviews, 2014
Quantity, quality, and lifespan are 3 important factors in the physiology, pathology, and transfusion of human blood platelets. The aim of this review is to discuss the proteolytic regulation of key platelet-specific receptors, glycoprotein(GP)Ib and GPVI, involved in the function of platelets in hemostasis and thrombosis, and nonimmune or immune ...
Elizabeth E, Gardiner, Robert K, Andrews
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