Results 131 to 140 of about 46,379 (251)

Platelet glycoprotein VI modulates leukocyte characteristics in sepsis-induced systemic inflammatory response in male mice. [PDF]

Physiol Rep
Corken A, Ware J, Thakali KM.
europepmc   +1 more source

Comprehensive analysis of glycoprotein VI-mediated platelet activation signaling pathway for predicting pan-cancer survival and response to anti-PD-1 immunotherapy. [PDF]

Comput Struct Biotechnol J, 2023
Chen S, Zhang L, Chen L, Huang Q, Wang Y, Liang Y.   +5 more
europepmc   +1 more source

An Engineered HR1‐Stem Helix‐HR2 Trimeric Platform for Developing Broad‐Spectrum Coronavirus Vaccines

Advanced Science, EarlyView.
Sun et al. report a self‐assembling trimeric subunit vaccine platform termed RHS, which integrates the JN.1 receptor‐binding domain (RBD) with the heptad repeat 1 (HR1), stem helix (SH), and heptad repeat 2 (HR2) regions. The SARS‐CoV‐2 RHS vaccine elicits variant‐reactive RBD‐specific antibodies and cross‐reactive SH‐specific antibodies against ...
Xikui Sun, Junhao Fan, Xiaolu Xie, Yuting Shi, Xiaoqing Liu, Tiefeng Xu, Sidi Yang, Keda Shi, Chengshu Xie, Shixiong Li, Siwen Chen, Ruoxi Cai, Ping He, Yuzhen Ye, Tao Chen, Xiancai Ma, Chunmei Li, Jingyou Yu, Deyin Guo   +18 more
wiley   +1 more source

Partial downregulation of platelet glycoprotein VI by low affinity antibodies confers sustained and safe antithrombotic protection. [PDF]

Signal Transduct Target Ther
Navarro S, Beck S, Bonfiglio SI, Cuenca-Zamora EJ, Weiß LJ, Kuijpers M, Heemskerk J, Stegner D, Nieswandt B.   +8 more
europepmc   +1 more source

Evaluation of the effect of eltrombopag therapy on the platelet collagen receptor glycoprotein VI (GPVI) expression and soluble GPVI levels in young patients with immune thrombocytopenia. [PDF]

J Thromb Thrombolysis, 2023
Tantawy AAG, Elsherif NHK, Ebeid FS, El-Gamal RAE, Ismail EAR, Kenny MA, Morcos MBE.   +6 more
europepmc   +1 more source

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis

Advanced Science, EarlyView.
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang, Siteng Li, Wenzhong Chen, Qingcheng Song, Haiyue Zhao, Peng Wang, Yiran Zhang, Wenquan Liang, Shaowei Zheng, Juan Wang, Wei Chen, Yanbin Zhu, Yingze Zhang   +12 more
wiley   +1 more source

Glycoprotein VI inhibitors: glenzocimab and EMA601 two inhibitory Fabs. [PDF]

Eur Heart J
Mangin PH, Jandrot-Perrus M.
europepmc   +1 more source

Respective roles of Glycoprotein VI and FcγRIIA in the regulation of αIIbβ3-mediated platelet activation to fibrinogen, thrombus buildup, and stability. [PDF]

Res Pract Thromb Haemost, 2021
Ahmed MU, Receveur N, Janus-Bell E, Mouriaux C, Gachet C, Jandrot-Perrus M, Hechler B, Gardiner EE, Mangin PH.   +8 more
europepmc   +1 more source

Platelet receptor glycoprotein VI

Clinical & Experimental Thrombosis and Hemostasis, 2020
openaire   +1 more source

Unravelling the Distinct Phenotype and Mechanosensitive Properties of Different Tendon Cell Populations

Advanced Science, EarlyView.
Tendon interfascicular and fascicular matrix cells are isolated and cultured, revealing distinct phenotypes and mechanosensitive responses. Interfascicular matrix cells exhibit marked stiffness‐dependent phenotypic plasticity, whereas fascicular matrix cells remain comparatively stable.
S. E. Grossemy, D. E. Zamboulis, N. S. Khatib, M. R. Fazal, C. C. Gains, A. Giannopoulos, T. Hopkins, C. Bevan, Y. Aggarwal, M. M. Knight, H. R. C. Screen   +10 more
wiley   +1 more source