Platelet glycoprotein VI modulates leukocyte characteristics in sepsis‐induced systemic inflammatory response in male mice [PDF]
Physiological ReportsPlatelets are responsible for maintaining vascular integrity through the process of hemostasis with glycoprotein VI (GPVI) acting as a major receptor for platelet activation.
Adam Corken +2 more
doaj +3 more sources
Comparison of the GPVI inhibitors losartan and honokiol [PDF]
Platelets, 2020 Losartan and honokiol are small molecules which have been described to inhibit aggregation of platelets by collagen. Losartan has been proposed to block clustering of GPVI but not to affect binding of collagen. Honokiol has been reported to bind directly
Magdolna Nagy +2 more
exaly +4 more sources
Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation [PDF]
Platelets, 2017 The tetraspanins are a superfamily of four-transmembrane proteins, which regulate the trafficking, lateral diffusion and clustering of the transmembrane proteins with which they interact.
Peter J Noy +2 more
exaly +3 more sources
Partial downregulation of platelet glycoprotein VI by low affinity antibodies confers sustained and safe antithrombotic protection [PDF]
Signal Transduction and Targeted TherapyGlycoprotein (GP) VI is a platelet-specific activating receptor for collagen and fibrin(ogen), and a promising target for antithrombotic therapy. Inhibitory Fab fragments against GPVI provide robust protection in mouse models of arterial thrombosis and ...
Stefano Navarro +8 more
doaj +2 more sources
Serum GPVI for Diagnostic Assessment and Short-Term Risk Stratification in Patients with Suspected Transient Ischemic Attack: A Prospective Observational Cohort Study [PDF]
Brain SciencesBackground/Objectives: Transient ischemic attack (TIA) is a neurological emergency associated with a substantial early risk of ischemic stroke, yet its diagnosis remains clinically challenging because objective biomarkers are limited.
Ömer Gençer +5 more
doaj +2 more sources
When GPVI Goes Rogue: Pathogenesis and Therapeutic Horizons in ITP [PDF]
Expert Reviews in Molecular MedicineImmune thrombocytopenia (ITP) is a heterogeneous autoimmune disorder characterized by immune-mediated platelet destruction, impaired thrombopoiesis and a bleeding diathesis, with growing recognition of accompanying inflammatory and immunoregulatory ...
Jalal Naghinezhad +5 more
doaj +2 more sources
Does fibrin(ogen) bind to monomeric or dimeric GPVI, or not at all?
Platelets, 2019 GPVI is the major signalling receptor for collagen on platelets. Dimerization of GPVI is required for collagen binding and initiation of signalling through the associated FcR-γ chain.
Alexandre Slater +2 more
exaly +2 more sources
PLoS ONE, 2022 ObjectivesPlatelet activation underpins thrombus formation in ischemic stroke. The active, dimeric form of platelet receptor glycoprotein (GP) VI plays key roles by binding platelet ligands collagen and fibrin, leading to platelet activation.
Isuru Induruwa +17 more
doaj +1 more source
Minimal Collagen-Binding Epitope of Glycoprotein VI in Human and Mouse Platelets
Biomedicines, 2023 Glycoprotein VI (GPVI) is a platelet-specific receptor for collagen and fibrin, regulating important platelet functions such as platelet adhesion and thrombus growth. Although the blockade of GPVI function is widely recognized as a potent anti-thrombotic
Chao Han +15 more
doaj +1 more source
Research and Practice in Thrombosis and Haemostasis, 2022 Background In the fibrin‐forming process, thrombin cleaves fibrinogen to fibrin, which form fibrils and then fibers, producing a gel‐like clot. Thrombin also activates coagulation factor XIII (FXIII), which crosslinks fibrin γ‐chains and α‐chains ...
Masaaki Moroi +3 more
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