Results 31 to 40 of about 4,333 (173)

Tetraspanin Tspan9 regulates platelet collagen receptor GPVI lateral diffusion and activation

Platelets, 2017
The tetraspanins are a superfamily of four-transmembrane proteins, which regulate the trafficking, lateral diffusion and clustering of the transmembrane proteins with which they interact.
Elizabeth J. Haining, Alexandra L. Matthews, Peter J. Noy, Hanna M. Romanska, Helen J. Harris, Jeremy Pike, Martina Morowski, Rebecca L. Gavin, Jing Yang, Pierre-Emmanuel Milhiet, Fedor Berditchevski, Bernhard Nieswandt, Natalie S. Poulter, Steve P. Watson, Michael G. Tomlinson   +14 more
doaj   +1 more source

Restrained glycoprotein VI-induced platelet signaling by tyrosine protein phosphatases independent of phospholipase Cγ2

Bleeding, Thrombosis and Vascular Biology, 2023
The platelet collagen receptor glycoprotein VI (GPVI) signals to activation of phospholipase Cγ2 (PLCγ2) and phosphoinositide 3-kinases (PI3K), causing platelet activation and aggregation.
Jingnan Huang, Delia I. Fernández, Jinmi Zou, Xueqing Wang, Johan W.M. Heemskerk, Ángel García   +5 more
doaj   +1 more source

ADPase CD39 Fused to Glycoprotein VI‐Fc Boosts Local Antithrombotic Effects at Vascular Lesions

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundGPVI (Glycoprotein VI) is the essential platelet collagen receptor in atherothrombosis. Dimeric GPVI‐Fc (Revacept) binds to GPVI binding sites on plaque collagen. As expected, it did not increase bleeding in clinical studies.
Heidrun Degen, Oliver Borst, Melanie Ziegler, Ann‐Katrin Mojica Munoz, Janina Jamasbi, Britta Walker, Silvia Göbel, Julia Fassbender, Kristin Adler, Richard Brandl, Götz Münch, Reinhard Lorenz, Wolfgang Siess, Meinrad Gawaz, Martin Ungerer   +14 more
doaj   +1 more source

α2β1 integrin, GPVI receptor, and common FcRγ chain on mouse platelets mediate distinct responses to collagen in models of thrombosis.

PLoS ONE, 2014
ObjectivePlatelets express the α2β1 integrin and the glycoprotein VI (GPVI)/FcRγ complex, both collagen receptors. Understanding platelet-collagen receptor function has been enhanced through use of genetically modified mouse models.
Robin J Marjoram, Zhengzhi Li, Li He, Douglas M Tollefsen, Thomas J Kunicki, S Kent Dickeson, Samuel A Santoro, Mary M Zutter   +7 more
doaj   +1 more source

Dynamin 2 is required for GPVI signaling and platelet hemostatic function in mice

Haematologica, 2020
Receptor-mediated endocytosis, which contributes to a wide range of cellular functions, including receptor signaling, cell adhesion, and migration, requires endocytic vesicle release by the large GTPase dynamin 2.
Nathan Eaton, Caleb Drew, Jon Wieser, Adam D. Munday, Hervé Falet   +4 more
doaj   +1 more source

GPVI inhibitor as antitumor gateway drug [PDF]

Blood, 2019
In this issue of Blood, Volz et al establish a potential antitumor strategy by exploiting the selective requirement for platelets to maintain vascular integrity within the tumor microenvironment.1 Their work demonstrates, for the first time, that functional inhibition of platelet-specific surface receptor glycoprotein (GP) VI, using F(ab′)2 fragments ...
openaire   +2 more sources

GPVI deficiency reduces clot size and murine thrombosis in normoglycaemic but not hyperglycemic conditions

Platelets
Background Glycoprotein (GP)VI is involved in platelet activation, procoagulant phenotype development and reactive oxygen species (ROS) production. Patients with diabetes have altered platelet reactivity and abnormal clot structure, contributing to ...
Julia S. Gauer, Cédric Duval, Helen R. McPherson, Amanda D. V. MacCannell, Lee D. Roberts, Khalid M. Naseem, Ramzi A. Ajjan, Robert A. S. Ariëns   +7 more
doaj   +1 more source

Regulation of platelet activation and thrombus formation by reactive oxygen species

Redox Biology, 2018
Reactive oxygen species (ROS) are generated within activated platelets and play an important role in regulating platelet responses to collagen and collagen-mediated thrombus formation.
Jianlin Qiao, Jane F. Arthur, Elizabeth E. Gardiner, Robert K. Andrews, Lingyu Zeng, Kailin Xu   +5 more
doaj   +1 more source

Fibrin activates GPVI in human and mouse platelets [PDF]

Blood, 2015
Key PointsFibrin is a novel ligand for the platelet collagen receptor, GPVI, increasing platelet procoagulant activity. Activation of GPVI by fibrin contributes to thrombus growth and stabilization.
Osama M, Alshehri, Craig E, Hughes, Samantha, Montague, Stephanie K, Watson, Jon, Frampton, Markus, Bender, Steve P, Watson   +6 more
openaire   +2 more sources

Janus kinase inhibitors ruxolitinib and baricitinib impair glycoprotein-VI mediated platelet function

Platelets, 2022
Several Janus kinase (JAK) inhibitors (jakinibs) have recently been approved to treat inflammatory, autoimmune and hematological conditions. Despite emerging roles for JAKs and downstream signal transducer and activator of transcription (STAT) proteins ...
Iván Parra-Izquierdo, Alexander R. Melrose, Jiaqing Pang, Hari Hara Sudhan Lakshmanan, Stéphanie E. Reitsma, Sai Hitesh Vavilapalli, Mark K. Larson, Joseph J. Shatzel, Owen J. T. McCarty, Joseph E. Aslan   +9 more
doaj   +1 more source