Results 41 to 50 of about 6,222 (193)

Structure-function relationship of the platelet glycoprotein VI (GPVI) receptor: does it matter if it is a dimer or monomer?

Platelets, 2021
GPVI is a critical signaling receptor responsible for collagen-induced platelet activation and a promising anti-thrombotic target in conditions such as coronary artery thrombosis, ischemic stroke, and atherothrombosis. This is due to the ability to block
Joanne C. Clark, Foteini-Nafsika Damaskinaki, Yam Fung Hilaire Cheung, Alexandre Slater, Steve P. Watson   +4 more
doaj   +1 more source

Device-Induced Blood Damage in Pump-Assisted Circulation: A Comparative Study of HeartMate III and BrioVAD Pumps. [PDF]

Artif Organs
Shear‐induced blood damage—including hemolysis, platelet and neutrophil injury, and von Willebrand factor (vWF) degradation—was evaluated for the BrioVAD and HM3 using an in vitro circulatory loop under clinically relevant conditions. Across 15 biomarkers (n > 6 per group), no significant differences were observed between the two devices.
Sun W, Clark KP, Tran D, Vandenberge JC, Kim N, Wang S, Tarafder A, Perez R, Griffith BP, Han D.   +9 more
europepmc   +2 more sources

Comparison of GPVI expression between control and stroke cohorts and GPVI-dimer as a function of total GPVI in control and stroke cohorts.

, 2022
A) Total GPVI and B) GPVI-dimer are both significantly higher in the stroke population at admission compared to the control cohort (P P-values were calculated using an unpaired t-test and the error bars represent the mean MFI of each of the cohorts ± SD.
Richard Farndale (11965393), Willem Ouwehand (269630), Masaaki Moroi (11965396), Jean-Daniel Malcor (2105536), Karola Rehnstrom (5658886), Arkadiusz Bonna (1719886), Elaine Bumanlag-Amis (11965387), Isuru Induruwa (6853274), Sophie Ashford (11965390), Harriet McKinney (11965375), Joanne McGee (11965384), Joana Batista (11965381), Kate Downes (242215), Elizabeth Warburton (3269124), Carly Kempster (11965378), Patrick Thomas (1699507), Stephanie Jung (704917), Kenji Soejima (371282)   +17 more
core   +1 more source

ADPase CD39 Fused to Glycoprotein VI‐Fc Boosts Local Antithrombotic Effects at Vascular Lesions

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2017
BackgroundGPVI (Glycoprotein VI) is the essential platelet collagen receptor in atherothrombosis. Dimeric GPVI‐Fc (Revacept) binds to GPVI binding sites on plaque collagen. As expected, it did not increase bleeding in clinical studies.
Heidrun Degen, Oliver Borst, Melanie Ziegler, Ann‐Katrin Mojica Munoz, Janina Jamasbi, Britta Walker, Silvia Göbel, Julia Fassbender, Kristin Adler, Richard Brandl, Götz Münch, Reinhard Lorenz, Wolfgang Siess, Meinrad Gawaz, Martin Ungerer   +14 more
doaj   +1 more source

Restrained glycoprotein VI-induced platelet signaling by tyrosine protein phosphatases independent of phospholipase Cγ2

Bleeding, Thrombosis and Vascular Biology, 2023
The platelet collagen receptor glycoprotein VI (GPVI) signals to activation of phospholipase Cγ2 (PLCγ2) and phosphoinositide 3-kinases (PI3K), causing platelet activation and aggregation.
Jingnan Huang, Delia I. Fernández, Jinmi Zou, Xueqing Wang, Johan W.M. Heemskerk, Ángel García   +5 more
doaj   +1 more source

α2β1 integrin, GPVI receptor, and common FcRγ chain on mouse platelets mediate distinct responses to collagen in models of thrombosis.

PLoS ONE, 2014
ObjectivePlatelets express the α2β1 integrin and the glycoprotein VI (GPVI)/FcRγ complex, both collagen receptors. Understanding platelet-collagen receptor function has been enhanced through use of genetically modified mouse models.
Robin J Marjoram, Zhengzhi Li, Li He, Douglas M Tollefsen, Thomas J Kunicki, S Kent Dickeson, Samuel A Santoro, Mary M Zutter   +7 more
doaj   +1 more source

GPVI-mediated Ca²⁺ release is sensitive to inhibitors of Trx-R and Trx.

, 2016
Washed human platelets were loaded with 3 μM fura2-AM and Ca2+ release monitored at 340nm and 380nm. Fluorescence was monitored for 5 cycles to obtain a baseline reading, following which drug was added for approx.
Stuart J. Mundell (311222), Clive Metcalfe (538890), Anjana Ramasubramoni (3204102), Matthew T. Harper (287910), Carmen H. Coxon (298171), Giordano Pula (640787)   +5 more
core   +1 more source

Immobilized fibrinogen activates human platelets through GPVI [PDF]

, 2018
GPVI, a major platelet activation receptor for collagen and fibrin, is considered as a particularly promising safe antithrombotic target. In this study, we show that human GPVI signals upon platelet adhesion to fibrinogen.
Hughes, CE, Loyau, S, Watson, Steve P., Amir K Babar, Miller, Jeanette L C, Robert AS Ariëns, Marie-Blanche Onselaer, Babar, AK, Mangin, PH, Receveur, Nicolas, Hardy, AT, Babar, Amir K., Le Lay, N, Philippou, H, Mangin, Pierre H, Craig E Hughes, Philippou, Helen, Nicolas Receveur, Receveur, N, Steve P. Watson, Babar, Amir K, Dupuis, Arnaud, Miller, JLC, Jandrot-Perrus, Martine, Mangin, Pierre H., Sanchez, Ximena, Arnaud Dupuis, Herr, Andrew B, Mezzano, Diego, Andrew B Herr, Onselaer, Marie-Blanche, Ximena Sanchez, Helen Philippou, Watson, Steve; id_orcid, Martine Jandrot-Perrus, Watson, SP, Herr, AB, Jandrot-Perrus, M, Mezzano, D, Wilson, Clare, Miller, Jeanette L. C., Sanchez, X, Alexander T Hardy, Hardy, Alexander, Jeanette LC Miller, Gachet, C, Nicolas Le Lay, Ariens, Robert A., Dupuis, A, Diego Mezzano, Ariëns, Robert A. S., Le Lay, Nicolas, Hardy, Alexander T., Herr, Andrew B., Ariëns, RAS, Pierre H Mangin, Gachet, Christian, Christian Gachet, Onselaer, Marie Blanche, Onselaer, MB, Clare Wilson, Stéphane Loyau, Loyau, Stephane, Wilson, C, Hughes, Craig, Hughes, Craig E.   +65 more
core   +1 more source

GPVI deficiency reduces clot size and murine thrombosis in normoglycaemic but not hyperglycemic conditions

Platelets
Background Glycoprotein (GP)VI is involved in platelet activation, procoagulant phenotype development and reactive oxygen species (ROS) production. Patients with diabetes have altered platelet reactivity and abnormal clot structure, contributing to ...
Julia S. Gauer, Cédric Duval, Helen R. McPherson, Amanda D. V. MacCannell, Lee D. Roberts, Khalid M. Naseem, Ramzi A. Ajjan, Robert A. S. Ariëns   +7 more
doaj   +1 more source

GPVI inhibitor as antitumor gateway drug [PDF]

Blood, 2019
In this issue of Blood, Volz et al establish a potential antitumor strategy by exploiting the selective requirement for platelets to maintain vascular integrity within the tumor microenvironment.1 Their work demonstrates, for the first time, that functional inhibition of platelet-specific surface receptor glycoprotein (GP) VI, using F(ab′)2 fragments ...
openaire   +2 more sources