Results 61 to 70 of about 4,333 (173)

Prothrombotic Activation of Platelet Pannexin‐1 Channels in Antiphospholipid Syndrome

Arthritis &Rheumatology, Volume 78, Issue 4, Page 896-903, April 2026.
Objective ATP is released from platelets through both degranulation and pannexin‐1 (PANX1) channels. ATP then activates P2X receptors to amplify platelet activation via calcium‐dependent signaling. The objective of this study was to evaluate the role of platelet PANX1 channels in the pathophysiology of antiphospholipid syndrome (APS), an acquired ...
Bruna de Moraes Mazetto Fonseca, Somanathapura K. NaveenKumar, Srilakshmi Yalavarthi, Kavya Sugur, Thalia G. Newman, Claire K. Hoy, Cyrus Sarosh, Jordan K. Schaefer, Ajay Tambralli, Jacqueline A. Madison, Yu Zuo, Fernanda A. Orsi, Michael Holinstat, Jason S. Knight   +13 more
wiley   +1 more source

Nanobodies to GPVI as alternative reagents for platelet spreading

Platelets
Platelet spreading assays are widely used to assess platelet adhesion, cytoskeletal remodeling and receptor‑specific signaling, but current GPVI ligands such as Collagen Related Peptide (CRP‑XL) suffer from non‑defined structure, batch variability, and ...
Alexandre Slater, Hsin-Yun Pan, Tzu-Han Ho, Eleyna M. Martin, Stephen P. Watson, Jeremy A. Pike, Natalie S. Poulter, Steven G. Thomas   +7 more
doaj   +1 more source

Discovery of novel GPVI receptor antagonists by structure-based repurposing.

PLoS ONE, 2014
Inappropriate platelet aggregation creates a cardiovascular risk that is largely managed with thienopyridines and aspirin. Although effective, these drugs carry risks of increased bleeding and drug 'resistance', underpinning a drive for new antiplatelet ...
Lewis Taylor, Sridhar R Vasudevan, Chris I Jones, Jonathan M Gibbins, Grant C Churchill, R Duncan Campbell, Carmen H Coxon   +6 more
doaj   +1 more source

Overcoming challenges in developing small molecule inhibitors for GPVI and CLEC-2

Platelets, 2021
GPVI and CLEC-2 have emerged as promising targets for long-term prevention of both arterial thrombosis and thrombo-inflammation with a decreased bleeding risk relative to current drugs.
Foteini-Nafsika Damaskinaki, Luis A. Moran, Angel Garcia, Barrie Kellam, Steve P. Watson   +4 more
doaj   +1 more source

Improved platelet recovery in cryopreserved platelets reconstituted in freeze‐dried plasma

Transfusion, Volume 66, Issue 4, Page 803-813, April 2026.
Abstract Background Cryopreserved platelets can support availability in settings where fresh platelets are inaccessible. Freeze‐dried plasma (FDP) may serve as an alternative reconstitution medium to fresh frozen plasma (FFP) when plasma thawing is impractical. The effects of FDP on cryopreserved platelet quality remain underexplored. Thus, we aimed to
Kristina Ehn, Per Sandgren, Klara Asplund Högelin, Agneta Wikman   +3 more
wiley   +1 more source

Assessment of Platelet Storage Lesions, Viability, and Function in Canine Platelet Concentrate Units Stored at 4°C for 14 Days

Journal of Veterinary Emergency and Critical Care, Volume 36, Issue 2, Page 177-188, March/April 2026.
ABSTRACT Objective To assess platelet function, storage lesion development, and bacterial contamination in canine platelet concentrate (PC) units stored at 4°C for 14 days. Design Prospective, in vitro experimental study. Setting University teaching hospital. Animals Six units of canine PC.
Kate S. Farrell, Steven E. Epstein, Nghi Nguyen, Ronald H. L. Li   +3 more
wiley   +1 more source

High-throughput elucidation of thrombus formation reveals sources of platelet function variability

Haematologica, 2019
In combination with microspotting, whole-blood microfluidics can provide high-throughput information on multiple platelet functions in thrombus formation.
Johanna P. van Geffen, Sanne L.N. Brouns, Joana Batista, Harriet McKinney, Carly Kempster, Magdolna Nagy, Suthesh Sivapalaratnam, Constance C.F.M.J. Baaten, Nikki Bourry, Mattia Frontini, Kerstin Jurk, Manuela Krause, Daniele Pillitteri, Frauke Swieringa, Remco Verdoold, Rachel Cavill, Marijke J. E. Kuijpers, Willem H. Ouwehand, Kate Downes, Johan W.M. Heemskerk   +19 more
doaj   +1 more source

Clinical significance of receptor shedding-platelet GPVI as an emerging diagnostic and therapeutic tool

Platelets, 2017
Platelet membrane bedecked with a wide array of receptors offers a platform to regulate platelet responsiveness, thrombotic propensity, inflammatory disposition, and immune reactivity under diverse pathophysiological conditions.
Madhumita Chatterjee, Meinrad Gawaz
doaj   +1 more source

TGFβ enhances platelet–breast‐cancer‐cell interaction and promotes platelet aggregation

The FEBS Journal, Volume 293, Issue 4, Page 1045-1065, February 2026.
TGFβ stimulation promotes EMT in MCF7 cells, increasing their ability to bind, activate, and aggregate PLT. This effect involves the upregulation of adhesion molecules Integrin‐αv and Galectin‐3. Inhibiting Integrin‐αv or Galectin‐3, through Cilengitide and GB1103, reduces PLT adhesion to MCF7 and PLT aggregation, suggesting a mechanism linking TGFβ ...
Margherita Genitoni, Lucia Merolle, Agnese Razzoli, Eleonora Maurizi, Gaia Gavioli, Roberto Baricchi, Chiara Marraccini, Davide Schiroli   +7 more
wiley   +1 more source

Gene Targeting Implicates Cdc42 GTPase in GPVI and Non-GPVI Mediated Platelet Filopodia Formation, Secretion and Aggregation

PLoS ONE, 2011
Cdc42 and Rac1, members of the Rho family of small GTPases, play critical roles in actin cytoskeleton regulation. We have shown previously that Rac1 is involved in regulation of platelet secretion and aggregation. However, the role of Cdc42 in platelet activation remains controversial. This study was undertaken to better understand the role of Cdc42 in
Huzoor Akbar, Xun Shang, Rehana Perveen, Mark Berryman, Kevin Funk, James F Johnson, Narendra N Tandon, Yi Zheng   +7 more
openaire   +4 more sources