Results 81 to 90 of about 4,333 (173)

G6f-like is an ITAM-containing collagen receptor in thrombocytes.

PLoS ONE, 2012
Collagen activates mammalian platelets through a complex of the immunoglobulin (Ig) receptor GPVI and the Fc receptor γ-chain, which has an immunoreceptor tyrosine-based activation motif (ITAM).
Craig E Hughes, Uvaraj P Radhakrishnan, Marie Lordkipanidzé, Stuart Egginton, Johannes M Dijkstra, Pudur Jagadeeswaran, Stephen P Watson   +6 more
doaj   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Functional characterization of a nanobody-based glycoprotein VI-specific platelet agonist

Research and Practice in Thrombosis and Haemostasis
Background: Glycoprotein (GP)VI is a platelet-specific collagen receptor required for platelet activation during hemostasis. Platelet reactivity toward collagen is routinely assessed during diagnostic workup of platelet disorders.
Minka Zivkovic, Elisabeth Pols - van Veen, Vossa van der Vegte, Silvie A.E. Sebastian, Annick S. de Moor, Suzanne J.A. Korporaal, Roger E.G. Schutgens, Rolf T. Urbanus, Erik Beckers, Michiel Coppens, Jeroen Eikenboom, Louise Hooimeijer, Gerard Jansen, Roger Schutgens, Rolf Urbanus, Minka Zivkovic, Emile van den Akker, Wala Al Arashi, Ryanne Arisz, Lieke Baas, Ruben Bierings, Maartje van den Biggelaar, Johan Boender, Anske van der Bom, Mettine Bos, Martijn Brands, Annelien Bredenoord, Laura Bukkems, Lex Burdorf, Jessica Del Castillo Alferez, Michael Cloesmeijer, Marjon Cnossen, Mariëtte Driessens, Jeroen Eikenboom, Karin Fijnvandraat, Kathelijn Fischer, Geertje Goedhart, Tine Goedhart, Samantha Gouw, Rieke van der Graaf, Masja de Haas, Lotte Haverman, Jan Hazelzet, Shannon van Hoorn, Elise Huisman, Nathalie Jansen, Alexander Janssen, Sean de Jong, Sjoerd Koopman, Marieke Kruip, Sebastiaan Laan, Frank Leebeek, Nikki van Leeuwen, Hester Lingsma, Moniek de Maat, Ron Mathôt, Felix van der Meer, Karina Meijer, Sander Meijer, Stephan Meijer, Iris van Moort, Caroline Mussert, Hans Kristian Ploos van Amstel, Suzanne Polinder, Diaz Prameyllawati, Simone Reitsma, Eliza Roest, Lorenzo Romano, Saskia Schols, Roger Schutgens, Rolf Urbanus, Carin Uyl, Jan Voorberg, Huan Zhang, Minka Zivkovic   +74 more
doaj   +1 more source

Clustering of GPVI dimers upon adhesion to collagen as a mechanism to regulate GPVI signalling in platelets [PDF]

, 2017
Background: Platelet GPVI binding to subendothelial collagen exposed upon blood vessel injury initiates thrombus formation. Dimeric GPVI has high affinity for collagen and occurs constitutively on resting platelets. Objective: To identify higher order oligomerisation (clustering) of pre-existing GPVI-dimers upon interaction with collagen as a mechanism
Poulter, N. S., Pollitt, A. Y., Owen, D. M., Gardiner, E. E., Andrews, R. K., Shimizu, H., Ishikawa, D., Bihan, D., Farndale, R. W., Moroi, M., Watson, S. P., Jung, S. M.   +11 more
openaire  

Mechanism of Buyang Huanwu Decoction in Improving Heart Failure after Myocardial Infarction by Inhibiting Platelet Aggregation via Platelet Glycoprotein VI: An Investigation Based on Molecular Docking and Surface Plasmon Resonance

World Journal of Traditional Chinese Medicine
Objective: Postmyocardial infarction heart failure (HF post-MI) induces platelet disorders, increased blood viscosity, and thrombosis. Buyang Huanwu decoction (BHD), a classical Chinese formulation for Qi deficiency and blood stasis, has proven clinical ...
Zi-Yan Wang, Ying Li, Ao-Ao Wang, Xian Zhou, Guo-Yuan Zhang, Yan-Lei Ma, Yue Shi, Jian-Shu Song, Jin Zhang, Ce Cao, Lei Li, Jian-Xun Liu   +11 more
doaj   +1 more source

GPVI inhibition: Advancing antithrombotic therapy in cardiovascular disease

European Heart Journal - Cardiovascular Pharmacotherapy
Abstract Glycoprotein (GP) VI (GPVI) plays a major role in thrombosis but not haemostasis, making it a promising antithrombotic target. The primary role of GPVI on the surface of platelets is a signalling receptor for collagen, which is one of the most potent thrombotic sub-endothelial components that is exposed by atherosclerotic plaque
Alexandre Slater, Sophia Khattak, Mark R Thomas   +2 more
openaire   +2 more sources

OC 58.3 Affinity of anti-GPVI Antibodies Determines the Degree of Human and Mouse GPVI Depletion in vivo

Research and Practice in Thrombosis and Haemostasis, 2023
S. Navarro, S. Beck, M. Kuijpers, J.W.M. Heemskerk, D. Stegner, B. Nieswandt   +5 more
openaire   +1 more source

Characterization of Platelet Protein Alterations in Stored Platelet Concentrates. [PDF]

J Clin Med
Alhawiti NM, Alharbi AM, Barhoumi T, Madkhali HA, Alrfaei BM.   +4 more
europepmc   +1 more source

Receptor homodimerization significantly prolongs the lifetime of ligand-induced cross-linking of CLEC-2 but not GPVI. [PDF]

Blood Vessel Thromb Hemost
Clark JC, Martin EM, Slater A, Calebiro D, Koszegi Z, Watson SP.   +5 more
europepmc   +1 more source

Research advances on platelet glycoprotein VI in ischemic stroke. [PDF]

Thromb J
Xiang H, Ding K, Meng F, Huo M, Yao W, Wang H.   +5 more
europepmc   +1 more source