Results 101 to 110 of about 6,222 (193)

Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases

, 2010
Glycoprotein VI (GPVI) mediates platelet activation on exposed subendothelial collagens at sites of vascular injury and thereby contributes to normal hemostasis, but also to the occlusion of diseased vessels in the setting of myocardial infarction or ...
Hofmann, S., Nieswandt, B., Scheller, J., Markus Bender, Athena Chalaris, Michael Bösl, Attila Braun, Jürgen Scheller, Bender, M., Chalaris, A., Bernhard Nieswandt, Bösl, M., Stegner, D., David Stegner, Stefan Rose-John, Rose-John, S., Braun, A., Sebastian Hofmann   +17 more
core   +1 more source

Rapid ubiquitination of Syk following GPVI activation in platelets

Blood, 2005
AbstractSpleen tyrosine kinase (Syk) activation is a key intermediate step in the activation of platelets by the physiologic agonist collagen. We have found that Syk is rapidly ubiquitinated upon activation of platelets by collagen, collagen-related peptide (CRP), and convulxin.
Carol A, Dangelmaier, Patricia G, Quinter, Jianguo, Jin, Alexander Y, Tsygankov, Satya P, Kunapuli, James L, Daniel   +5 more
openaire   +3 more sources

A Humanized Glycoprotein VI (GPVI) Mouse Model to Assess the Antithrombotic Efficacies of Anti-GPVI Agents □ S [PDF]

, 2020
Glycoprotein VI (GPVI) has been proposed as a promising antiplatelet target, because its blockade prevents experimental thrombosis without impairing hemostasis.

core  

Mechanism of Buyang Huanwu Decoction in Improving Heart Failure after Myocardial Infarction by Inhibiting Platelet Aggregation via Platelet Glycoprotein VI: An Investigation Based on Molecular Docking and Surface Plasmon Resonance

World Journal of Traditional Chinese Medicine
Objective: Postmyocardial infarction heart failure (HF post-MI) induces platelet disorders, increased blood viscosity, and thrombosis. Buyang Huanwu decoction (BHD), a classical Chinese formulation for Qi deficiency and blood stasis, has proven clinical ...
Zi-Yan Wang, Ying Li, Ao-Ao Wang, Xian Zhou, Guo-Yuan Zhang, Yan-Lei Ma, Yue Shi, Jian-Shu Song, Jin Zhang, Ce Cao, Lei Li, Jian-Xun Liu   +11 more
doaj   +1 more source

Functional characterization of a nanobody-based glycoprotein VI-specific platelet agonist

Research and Practice in Thrombosis and Haemostasis
Background: Glycoprotein (GP)VI is a platelet-specific collagen receptor required for platelet activation during hemostasis. Platelet reactivity toward collagen is routinely assessed during diagnostic workup of platelet disorders.
Minka Zivkovic, Elisabeth Pols - van Veen, Vossa van der Vegte, Silvie A.E. Sebastian, Annick S. de Moor, Suzanne J.A. Korporaal, Roger E.G. Schutgens, Rolf T. Urbanus, Erik Beckers, Michiel Coppens, Jeroen Eikenboom, Louise Hooimeijer, Gerard Jansen, Roger Schutgens, Rolf Urbanus, Minka Zivkovic, Emile van den Akker, Wala Al Arashi, Ryanne Arisz, Lieke Baas, Ruben Bierings, Maartje van den Biggelaar, Johan Boender, Anske van der Bom, Mettine Bos, Martijn Brands, Annelien Bredenoord, Laura Bukkems, Lex Burdorf, Jessica Del Castillo Alferez, Michael Cloesmeijer, Marjon Cnossen, Mariëtte Driessens, Jeroen Eikenboom, Karin Fijnvandraat, Kathelijn Fischer, Geertje Goedhart, Tine Goedhart, Samantha Gouw, Rieke van der Graaf, Masja de Haas, Lotte Haverman, Jan Hazelzet, Shannon van Hoorn, Elise Huisman, Nathalie Jansen, Alexander Janssen, Sean de Jong, Sjoerd Koopman, Marieke Kruip, Sebastiaan Laan, Frank Leebeek, Nikki van Leeuwen, Hester Lingsma, Moniek de Maat, Ron Mathôt, Felix van der Meer, Karina Meijer, Sander Meijer, Stephan Meijer, Iris van Moort, Caroline Mussert, Hans Kristian Ploos van Amstel, Suzanne Polinder, Diaz Prameyllawati, Simone Reitsma, Eliza Roest, Lorenzo Romano, Saskia Schols, Roger Schutgens, Rolf Urbanus, Carin Uyl, Jan Voorberg, Huan Zhang, Minka Zivkovic   +74 more
doaj   +1 more source

Regulation of platelet glycoprotein VI (GPVI) surface expression and of soluble GPVI in patients with atrial fibrillation (AF) and acute coronary syndrome (ACS).

, 2009
The platelet collagen receptor glycoprotein VI (GPVI) mediates platelet adhesion to subendothelial matrix and thrombus formation in acute coronary syndrome (ACS).
Stellos, K., May, A.E., Seizer, P., Weig, H.J., Pötz, O., Kremmer, E., Geisler, T., Joos, T., Bigalke, B., Lindemann, S., Gawaz, M.   +10 more
core   +1 more source

Poster Sessions

HemaSphere, Volume 10, Issue S1, June 2026.
wiley   +1 more source

Role of GPVI/Fibrinogen interplay in platelet activation, thrombus formation and stability

, 2020
La GPVI, un membre de la superfamille des immunoglobulines, est exprimée uniquement dans les plaquettes et les mégacaryocytes. Comme les patients déficients en GPVI souffrent d'une diathèse hémorragique très légère et que les souris déficientes en GPVI ...
Ahmed, Muhammad Usman
core  

OC 58.3 Affinity of anti-GPVI Antibodies Determines the Degree of Human and Mouse GPVI Depletion in vivo

Research and Practice in Thrombosis and Haemostasis, 2023
S. Navarro, S. Beck, M. Kuijpers, J.W.M. Heemskerk, D. Stegner, B. Nieswandt   +5 more
openaire   +1 more source

Hypoxia suppresses platelet activity through GPVI down-regulation but paradoxically enhances arterial thrombosis via elevated vWF. [PDF]

Cardiovasc Res
Jha V, Kim JS, Ahmed M, Italiano JE, Razani B, Cho J.   +5 more
europepmc   +1 more source