Results 91 to 100 of about 6,222 (193)

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, Volume 15, Issue 20, 27 May 2026.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Clinical significance of receptor shedding-platelet GPVI as an emerging diagnostic and therapeutic tool

Platelets, 2017
Platelet membrane bedecked with a wide array of receptors offers a platform to regulate platelet responsiveness, thrombotic propensity, inflammatory disposition, and immune reactivity under diverse pathophysiological conditions.
Madhumita Chatterjee, Meinrad Gawaz
doaj   +1 more source

Gene Targeting Implicates Cdc42 GTPase in GPVI and Non-GPVI Mediated Platelet Filopodia Formation, Secretion and Aggregation

PLoS ONE, 2011
Cdc42 and Rac1, members of the Rho family of small GTPases, play critical roles in actin cytoskeleton regulation. We have shown previously that Rac1 is involved in regulation of platelet secretion and aggregation. However, the role of Cdc42 in platelet activation remains controversial. This study was undertaken to better understand the role of Cdc42 in
Huzoor Akbar, Xun Shang, Rehana Perveen, Mark Berryman, Kevin Funk, James F Johnson, Narendra N Tandon, Yi Zheng   +7 more
openaire   +4 more sources

Anti-GPVI Fab SAR264565 effectively blocks GPVI function in ex vivo human platelets under arterial shear in a perfusion chamber

, 2022
S.949-956Glycoprotein VI (GPVI) is the major platelet receptor for collagen-mediated platelet adhesion and activation. SAR264565 is an anti-GPVI-Fab, binds to GPVI with high affinity, and blocks GPVI function in human platelets in vitro.
Florian, P., Graff, J., Kuczka, K., Harder, S., Wonerow, P., Dubar, M.   +5 more
core   +1 more source

GPVI: An Internal Index Based on Grouping Partition for Clustering Validity Validation

International Journal of Computational Intelligence Systems
In supervised learning, algorithm evaluation is guided by those performance measures relying on known class labels, such as accuracy. Instead, in unsupervised learning, one can use internal indices that only rely on properties intrinsic to datasets as ...
Jinzhe Li, Xin Pan
doaj   +1 more source

The effects of signal transducer and activator of transcription three mutations on human platelets

Platelets, 2018
Involvement of signal transducer and activator of transcription 3 (STAT3) in inflammation is well known. Recently, a role for STAT3 in platelet activation and platelet production has been suggested.
Floor E. Aleva, Frank L. van de Veerdonk, Yang Li, Rahajeng N. Tunjungputri, Sami Simons, Philip G. De Groot, Mihai M. Netea, Yvonne F. Heijdra, Quirijn de Mast, André J.A.M. van der Ven   +9 more
doaj   +1 more source

Plasma levels of the soluble form of the FcγRIIa receptor vary with receptor polymorphisms and are elevated in rheumatoid arthritis

Platelets, 2020
Soluble forms of the low-affinity immunoglobulin receptor FcγRIIa (sFcγRIIa) lacking the cytoplasmic tail have been reported in plasma however the mechanism and functional consequences are unknown.
Jianlin Qiao, Eimear Dunne, Bruce Wines, Dermot Kenny, Geraldine M. McCarthy, P. Mark Hogarth, Kailin Xu, Robert K. Andrews, Elizabeth E. Gardiner   +8 more
doaj   +1 more source

Regulation of platelet membrane protein shedding in health and disease

Platelets, 2017
Extracellular proteolysis of platelet plasma membrane proteins is an event that ensues platelet activation. Shedding of surface receptors such as glycoprotein (GP) Ibα, GPV and GPVI as well as externalized proteins P-selectin and CD40L releases soluble ...
Amanda E. Au, Emma C. Josefsson
doaj   +1 more source

Clustering of GPVI dimers upon adhesion to collagen as a mechanism to regulate GPVI signalling in platelets [PDF]

, 2017
Background: Platelet GPVI binding to subendothelial collagen exposed upon blood vessel injury initiates thrombus formation. Dimeric GPVI has high affinity for collagen and occurs constitutively on resting platelets. Objective: To identify higher order oligomerisation (clustering) of pre-existing GPVI-dimers upon interaction with collagen as a mechanism
Poulter, N. S., Pollitt, A. Y., Owen, D. M., Gardiner, E. E., Andrews, R. K., Shimizu, H., Ishikawa, D., Bihan, D., Farndale, R. W., Moroi, M., Watson, S. P., Jung, S. M.   +11 more
openaire  

GPIb potentiates GPVI-induced responses in human platelets

Platelets, 2004
Platelet adhesion to vascular subendothelial proteins at the site of blood vessel injury is critical for initiating haemostasis. Collagen is a major matrix protein that binds plasma von Willebrand factor (vWF) when the endothelium becomes damaged and therefore in vivo platelets are likely to encounter both of these agonists simultaneously, through ...
Julie, Baker, Rebecca K L, Griggs, Shahrokh, Falati, Alastair W, Poole   +3 more
openaire   +2 more sources