Results 71 to 80 of about 6,222 (193)

GPVI modulation during platelet activation and storage: its expression levels and ectodomain shedding compared to markers of platelet storage lesion

Platelets, 2017
Platelet storage is associated with deleterious changes leading to the loss of platelet reactivity and response. During storage, platelets experience increased expression and shedding of P-selectin and CD40L as specific markers of platelet activation ...
Ehteramolsadat Hosseini, Mehran Ghasemzadeh, Fatemeh Nassaji, Zeynab Pirmohammad Jamaat   +3 more
doaj   +1 more source

NOVEL REGULATORS OF GPVI-MEDIATED PLATELET ACTIVATION [PDF]

, 2017
Platelets are anucleate cells that are crucial mediators of hemostasis and thrombosis. Under physiological conditions, platelets are maintained in a quiescent state within the vasculature.
Patel, Akruti
core   +1 more source

Platelet glycoprotein VI and C-type lectin-like receptor 2 deficiency accelerates wound healing by impairing vascular integrity in mice

Haematologica, 2019
Platelets promote wound healing by forming a vascular plug and by secreting growth factors and cytokines. Glycoprotein (GP)VI and C-type lectin-like receptor (CLEC)-2 signal through a (hem)-immunoreceptor tyrosine-based activation motif, which induces ...
Surasak Wichaiyo, Sian Lax, Samantha J. Montague, Zhi Li, Beata Grygielska, Jeremy A. Pike, Elizabeth J. Haining, Alexander Brill, Steve P. Watson, Julie Rayes   +9 more
doaj   +1 more source

Respective roles of Glycoprotein VI and FcγRIIA in the regulation of αIIbβ3‐mediated platelet activation to fibrinogen, thrombus buildup, and stability

Research and Practice in Thrombosis and Haemostasis, 2021
Background The interplay between platelets and fibrinogen is the cornerstone of thrombus formation. Integrin αIIbβ3 is the main platelet adhesion receptor for fibrinogen and mediates an outside‐in signal upon ligand binding that reinforces platelet ...
Muhammad Usman Ahmed, Nicolas Receveur, Emily Janus‐Bell, Clarisse Mouriaux, Christian Gachet, Martine Jandrot‐Perrus, Béatrice Hechler, Elizabeth E. Gardiner, Pierre H. Mangin   +8 more
doaj   +1 more source

Tropomyosin 1 Promotes Platelet Adhesion and Clot Contraction Separate from Its Roles in Developmental Hematopoiesis

Advanced Science, Volume 13, Issue 48, 28 August 2026.
ABSTRACT Genome‐wide association studies (GWAS) link the Tropomyosin 1 (Tpm1) locus to quantitative blood trait variation, but related mechanisms are unclear. Tpm1 encodes an actin‐binding protein that regulates actin filament diversity, cell adhesion, signaling, and actomyosin contractility.
Po‐Lun Kung, Victor Tsao, Alina D Peshkova, Oscar A. Marcos‐Contreras, Kim Ha, Brian M Dulmovits, Nkemdilim Okoli, Anvi Sinha, Gennadiy Fonar, Rong Qiu, Rolf D Bates, Janelle Yeboah, Carson Shalaby, Tyler Truex, Soomin Jeong, Edna C Hardeman, Peter W Gunning, Vladimir R Muzykantov, Jacob W Myerson, Christopher S Thom   +19 more
wiley   +1 more source

Figure 8: Model of GPVI-Fc and Cross-Linked GPVI-Fc Binding to Plaque Collagen

, 2019
Cross-linking of dimeric glycoprotein VI–fragment crystallizable (GPVI-Fc) fusion protein (GPVI, brown; Fc, blue) by anti–Fc Fab2 creates oligomeric (n = 2 to 4) GPVI-Fc molecules, which bind to their corresponding motifs on collagen fibers more densely (
Kerstin Uhland (2092060), Reinhard Lorenz (6820967), Remco T.A. Megens (6820955), Shachar Sherman (6820961), Natalie Elia (660866), Mariaelvy Bianchini (6820958), Christine John (839705), Götz Münch (436471), Wolfgang Siess (168198), Johannes Buchner (277160), Alexander Faussner (781036), Christian Weber (86566), Martin Ungerer (436470), Richard Brandl (6820964), Janina Jamasbi (6820952)   +14 more
core   +1 more source

Anti-GPVI (HY101) activates platelets in a multicolor flow cytometry panel

Platelets, 2022
The platelet transmembrane receptor GPVI can be assessed together with other platelet membrane markers in a whole blood multicolor flow cytometry panel. The advantage of combining multiple antibodies in a single tube is the possibility of distinguishing ...
Marie-Astrid van Dievoet, Davide Brusa, Marie Octave, Sandrine Horman, Xavier Stephenne   +4 more
doaj   +1 more source

Targeting CD148 for Antithrombotic Therapy: Functional and Molecular Evaluation of AKB‐9778

Pharmacology Research &Perspectives, Volume 14, Issue 4, August 2026.
ABSTRACT CD148 is the primary receptor‐type protein tyrosine phosphatase (PTP) regulating platelet activation, and its inhibition has been proposed as a novel anti‐thrombotic strategy with potentially lower bleeding risk than current therapies. However, selective and potent inhibitors of CD148 are currently lacking.
Lina El Badaoui, Stipo Jurcevic, Yotis A. Senis, Alastair J. Barr   +3 more
wiley   +1 more source

Nanobodies to GPVI as alternative reagents for platelet spreading

Platelets
Platelet spreading assays are widely used to assess platelet adhesion, cytoskeletal remodeling and receptor‑specific signaling, but current GPVI ligands such as Collagen Related Peptide (CRP‑XL) suffer from non‑defined structure, batch variability, and ...
Alexandre Slater, Hsin-Yun Pan, Tzu-Han Ho, Eleyna M. Martin, Stephen P. Watson, Jeremy A. Pike, Natalie S. Poulter, Steven G. Thomas   +7 more
doaj   +1 more source

Haemostatic changes and bleeding with anti‐IL‐6 directed therapy in autoimmune diseases

British Journal of Pharmacology, Volume 183, Issue 15, Page 4111-4125, August 2026.
Abstract Anti‐IL‐6 directed therapy, especially tocilizumab (TCZ), is widely used for the treatment of autoimmune diseases such as rheumatoid arthritis, giant cell arteritis and systemic juvenile idiopathic arthritis. Next to being a master regulator of inflammation, IL‐6 also is an important regulator of haemostasis. Although generally well tolerated,
Charlotte D. C. C. van der Heijden, Loes C. Oskam, Lenny van Bon, Chantal P. Rovers   +3 more
wiley   +1 more source