Results 71 to 80 of about 4,333 (173)

Model systems for platelet receptor shedding

Platelets, 2017
Platelet adhesion and aggregation at sites of vascular injury are crucial for hemostasis; however, under pathological conditions, they can cause myocardial infarction and stroke.
Markus Bender, David Stegner, Bernhard Nieswandt   +2 more
doaj   +1 more source

Prevention of In‐Stent Restenosis After PCI by Saponin Natural Products: Inhibition of Platelet Activation

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT Percutaneous coronary intervention (PCI) enables coronary revascularisation and restores haemodynamic stability but also carries risks of delayed complications including in‐stent restenosis (ISR), a chronic progressive disease with endovascular damage after PCI, which compromises the long‐term efficacy of PCI.
Xueli Lei, Chunlei Lv, Yu Zhang, Zhiyu Li, Hao Shen, Li Zhu   +5 more
wiley   +1 more source

Basic mechanisms of platelet receptor shedding

Platelets, 2017
Proteolytic shedding of the extracellular ectodomain of platelet receptors provides a key mechanism for irreversible loss of ligand-binding capacity, and for regulating platelet function in health and disease.
Robert K. Andrews, Elizabeth E. Gardiner
doaj   +1 more source

Retention of critical platelet hemostatic functions of amotosalen‐UVA pathogen‐reduced cryoprecipitated fibrinogen complex

Transfusion, Volume 66, Issue 2, Page 393-404, February 2026.
Abstract Background Cryoprecipitate Anti‐Haemophilic Factor (CRYO‐AHF) is enriched for fibrinogen, VWF, FVIII, FXIII and fibronectin, but has short post‐thaw expiration due to risk of transfusion‐transmitted infection (TTI) limiting availability for rapid treatment.
Florian Tupin, Clarisse Mouriaux, Michelle Gatmaitan, Kaja Kaastrup, Subramanian Yegneswaran, Laurence Corash, Pierre H. Mangin   +6 more
wiley   +1 more source

GPVI: An Internal Index Based on Grouping Partition for Clustering Validity Validation

International Journal of Computational Intelligence Systems
In supervised learning, algorithm evaluation is guided by those performance measures relying on known class labels, such as accuracy. Instead, in unsupervised learning, one can use internal indices that only rely on properties intrinsic to datasets as ...
Jinzhe Li, Xin Pan
doaj   +1 more source

The effects of signal transducer and activator of transcription three mutations on human platelets

Platelets, 2018
Involvement of signal transducer and activator of transcription 3 (STAT3) in inflammation is well known. Recently, a role for STAT3 in platelet activation and platelet production has been suggested.
Floor E. Aleva, Frank L. van de Veerdonk, Yang Li, Rahajeng N. Tunjungputri, Sami Simons, Philip G. De Groot, Mihai M. Netea, Yvonne F. Heijdra, Quirijn de Mast, André J.A.M. van der Ven   +9 more
doaj   +1 more source

Plasma levels of the soluble form of the FcγRIIa receptor vary with receptor polymorphisms and are elevated in rheumatoid arthritis

Platelets, 2020
Soluble forms of the low-affinity immunoglobulin receptor FcγRIIa (sFcγRIIa) lacking the cytoplasmic tail have been reported in plasma however the mechanism and functional consequences are unknown.
Jianlin Qiao, Eimear Dunne, Bruce Wines, Dermot Kenny, Geraldine M. McCarthy, P. Mark Hogarth, Kailin Xu, Robert K. Andrews, Elizabeth E. Gardiner   +8 more
doaj   +1 more source

Affimer reagents as tool molecules to modulate platelet GPVI-ligand interactions and specifically bind GPVI dimer

Blood Advances
Abstract Glycoprotein VI (GPVI) plays a key role in collagen-induced platelet aggregation. Affimers are engineered binding protein alternatives to antibodies. We screened and characterized GPVI-binding Affimers as novel tools to probe GPVI function.
Rui-Gang Xu, Christian Tiede, Antonio N. Calabrese, Lih T. Cheah, Thomas L. Adams, Julia S. Gauer, Matthew S. Hindle, Beth A. Webb, Daisie M. Yates, Alexandre Slater, Cédric Duval, Khalid M. Naseem, Andrew B. Herr, Darren C. Tomlinson, Steve P. Watson, Robert A. S. Ariëns   +15 more
openaire   +3 more sources

Regulation of platelet membrane protein shedding in health and disease

Platelets, 2017
Extracellular proteolysis of platelet plasma membrane proteins is an event that ensues platelet activation. Shedding of surface receptors such as glycoprotein (GP) Ibα, GPV and GPVI as well as externalized proteins P-selectin and CD40L releases soluble ...
Amanda E. Au, Emma C. Josefsson
doaj   +1 more source

Rapid ubiquitination of Syk following GPVI activation in platelets

Blood, 2005
AbstractSpleen tyrosine kinase (Syk) activation is a key intermediate step in the activation of platelets by the physiologic agonist collagen. We have found that Syk is rapidly ubiquitinated upon activation of platelets by collagen, collagen-related peptide (CRP), and convulxin.
Carol A, Dangelmaier, Patricia G, Quinter, Jianguo, Jin, Alexander Y, Tsygankov, Satya P, Kunapuli, James L, Daniel   +5 more
openaire   +3 more sources