Results 51 to 60 of about 4,333 (173)

Novel antiplatelet strategies targeting GPVI, CLEC-2 and tyrosine kinases

Platelets, 2021
Antiplatelet medications comprise the cornerstone of treatment for diseases that involve arterial thrombosis, including acute coronary syndromes (ACS), stroke and peripheral arterial disease.
Maan H. Harbi, Christopher W. Smith, Phillip L. R. Nicolson, Steve P. Watson, Mark R. Thomas   +4 more
doaj   +1 more source

GPVI modulation during platelet activation and storage: its expression levels and ectodomain shedding compared to markers of platelet storage lesion

Platelets, 2017
Platelet storage is associated with deleterious changes leading to the loss of platelet reactivity and response. During storage, platelets experience increased expression and shedding of P-selectin and CD40L as specific markers of platelet activation ...
Ehteramolsadat Hosseini, Mehran Ghasemzadeh, Fatemeh Nassaji, Zeynab Pirmohammad Jamaat   +3 more
doaj   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, Volume 15, Issue 20, 27 May 2026.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Respective roles of Glycoprotein VI and FcγRIIA in the regulation of αIIbβ3‐mediated platelet activation to fibrinogen, thrombus buildup, and stability

Research and Practice in Thrombosis and Haemostasis, 2021
Background The interplay between platelets and fibrinogen is the cornerstone of thrombus formation. Integrin αIIbβ3 is the main platelet adhesion receptor for fibrinogen and mediates an outside‐in signal upon ligand binding that reinforces platelet ...
Muhammad Usman Ahmed, Nicolas Receveur, Emily Janus‐Bell, Clarisse Mouriaux, Christian Gachet, Martine Jandrot‐Perrus, Béatrice Hechler, Elizabeth E. Gardiner, Pierre H. Mangin   +8 more
doaj   +1 more source

LL‐37: Biological Mechanisms and Emerging Therapeutic Applications in Intestinal Disease

Immunity, Inflammation and Disease, Volume 14, Issue 5, May 2026.
ABSTRACT Human cathelicidin peptide LL‐37 is encoded by the CAMP gene and plays a key role in innate immunity. It maintains intestinal homeostasis through antibacterial, immunomodulation, and tissue repair functions. This paper reviews the multiple functions of LL‐37 in the intestinal‐immune axis and its contribution to intestinal immune homeostasis. A
Qichao Liu, Peng Xu, Cheng Zhang
wiley   +1 more source

Activation of GPVI by collagen is regulated by α2β1 and secondary mediators [PDF]

Journal of Thrombosis and Haemostasis, 2003
We have compared the roles of adenosine diphosphate (ADP), thromboxanes and the integrin alpha(2)beta(1) in the activation of washed platelets by collagen in the presence of the alpha(IIb)beta(3) antagonist lotrafiban. The stimulation of protein tyrosine phosphorylation by a collagen suspension is markedly delayed in the presence of the above ...
Atkinson, B.T., Jarvis, Gavin, Watson, S.P.   +2 more
openaire   +2 more sources

Platelet glycoprotein VI and C-type lectin-like receptor 2 deficiency accelerates wound healing by impairing vascular integrity in mice

Haematologica, 2019
Platelets promote wound healing by forming a vascular plug and by secreting growth factors and cytokines. Glycoprotein (GP)VI and C-type lectin-like receptor (CLEC)-2 signal through a (hem)-immunoreceptor tyrosine-based activation motif, which induces ...
Surasak Wichaiyo, Sian Lax, Samantha J. Montague, Zhi Li, Beata Grygielska, Jeremy A. Pike, Elizabeth J. Haining, Alexander Brill, Steve P. Watson, Julie Rayes   +9 more
doaj   +1 more source

Anti-GPVI (HY101) activates platelets in a multicolor flow cytometry panel

Platelets, 2022
The platelet transmembrane receptor GPVI can be assessed together with other platelet membrane markers in a whole blood multicolor flow cytometry panel. The advantage of combining multiple antibodies in a single tube is the possibility of distinguishing ...
Marie-Astrid van Dievoet, Davide Brusa, Marie Octave, Sandrine Horman, Xavier Stephenne   +4 more
doaj   +1 more source

Nanofibrous Platforms for Advanced Wound Therapeutics: Mechanisms, Materials, and Clinical Horizons

Macromolecular Bioscience, Volume 26, Issue 5, May 2026.
The fabrication of nanofiber dressings from diverse natural and synthetic polymers offers a robust platform for chronic wound management. By encapsulating therapeutic drugs and bioactive agents, these dressings can simultaneously attenuate chronic inflammation and microbial infection while actively stimulating angiogenesis, addressing the primary ...
Wanho Cho, Chungmo Yang, Hyuk Sang Yoo
wiley   +1 more source

Inhibition of Glycoprotein VI Clustering by Collagen as a Mechanism of Inhibiting Collagen-Induced Platelet Responses: The Example of Losartan. [PDF]

PLoS ONE, 2015
Exposure of platelets to collagen triggers the formation of a platelet clot. Pharmacological agents capable of inhibiting platelet activation by collagen are thus of potential therapeutic interest.
Peng Jiang, Stéphane Loyau, Maria Tchitchinadze, Jacques Ropers, Guillaume Jondeau, Martine Jandrot-Perrus   +5 more
doaj   +1 more source