Results 51 to 60 of about 6,222 (193)

Dynamin 2 is required for GPVI signaling and platelet hemostatic function in mice

Haematologica, 2020
Receptor-mediated endocytosis, which contributes to a wide range of cellular functions, including receptor signaling, cell adhesion, and migration, requires endocytic vesicle release by the large GTPase dynamin 2.
Nathan Eaton, Caleb Drew, Jon Wieser, Adam D. Munday, Hervé Falet   +4 more
doaj   +1 more source

Janus kinase inhibitors ruxolitinib and baricitinib impair glycoprotein-VI mediated platelet function

Platelets, 2022
Several Janus kinase (JAK) inhibitors (jakinibs) have recently been approved to treat inflammatory, autoimmune and hematological conditions. Despite emerging roles for JAKs and downstream signal transducer and activator of transcription (STAT) proteins ...
Iván Parra-Izquierdo, Alexander R. Melrose, Jiaqing Pang, Hari Hara Sudhan Lakshmanan, Stéphanie E. Reitsma, Sai Hitesh Vavilapalli, Mark K. Larson, Joseph J. Shatzel, Owen J. T. McCarty, Joseph E. Aslan   +9 more
doaj   +1 more source

Commonalities of platelet dysfunction in heart failure with preserved ejection fraction and underlying comorbidities

ESC Heart Failure, Volume 12, Issue 2, Page 1013-1028, April 2025.
Abstract Heart failure with preserved ejection fraction (HFpEF) is characterized by a lack of a specific targeted treatment and a complex, partially unexplored pathophysiology. Common comorbidities associated with HFpEF are hypertension, atrial fibrillation, obesity and diabetes.
Giorgia D'Italia, Blanche Schroen, Judith M.E.M. Cosemans   +2 more
wiley   +1 more source

Platelet glycoprotein VI genetic quantitative and qualitative defects

Platelets, 2019
Platelet membrane glycoprotein VI (GPVI) is increasingly recognized as an important receptor for thrombus formation and growth. Numerous arguments have been published indicating that GPVI plays a major role in thrombosis without being essential for ...
Martine Jandrot-Perrus, Cedric Hermans, Diego Mezzano   +2 more
doaj   +1 more source

Regulation of platelet activation and thrombus formation by reactive oxygen species

Redox Biology, 2018
Reactive oxygen species (ROS) are generated within activated platelets and play an important role in regulating platelet responses to collagen and collagen-mediated thrombus formation.
Jianlin Qiao, Jane F. Arthur, Elizabeth E. Gardiner, Robert K. Andrews, Lingyu Zeng, Kailin Xu   +5 more
doaj   +1 more source

Unraveling the Plasma Extracellular Vesicles Proteome: Predictors of Resistance in Immunotherapy of Advanced Melanoma

International Journal of Cancer, EarlyView.
ABSTRACT Despite substantial clinical benefit from immune checkpoint inhibitors (ICI), advanced melanoma remains challenging due to frequent treatment resistance. Resistance may be intrinsic (primary) or emerge over time (secondary). Biomarkers predicting distinct resistance phenotypes before therapy are lacking.
Julian Kött, Glenn Geidel, Carmen M. T. Roeper, Lucija Ačkar, Bente Siebels, Hannah Voß, Hartmut Schlüter, Michaela Schweizer, Kilian Müller, Alessandra Rünger, Tim Zell, Benjamin Deitert, Ali Zeinal‐Abedini, Isabel Heidrich, Stefan W. Schneider, Klaus Pantel, Daniel J. Smit, Christoffer Gebhardt   +17 more
wiley   +1 more source

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source

Platelet GPVI repairs its own damage [PDF]

Blood, 2015
In this issue of Blood, Gros et al report that glycoprotein VI (GPVI) promotes the proinflammatory role of platelets by increasing neutrophil secretion and toxicity while at the same time repairing the vascular damage inflicted by neutrophil activation, thereby maintaining vascular integrity. Significantly, this effect is independent of hemostasis.
Julie, Rayes, Steve P, Watson
openaire   +2 more sources

Platelets modulate cardiac remodeling via the collagen receptor GPVI after acute myocardial infarction

Frontiers in Immunology
IntroductionPlatelets play an important role in cardiovascular diseases. After acute myocardial infarction, platelets display enhanced activation and migrate into the infarct zone.
Friedrich Reusswig, Matthias Dille, E. Krüger, J. Ortscheid, Tobias Feige, S. Gorressen, J.-W. Fischer, Margitta Elvers   +7 more
doaj   +1 more source

Predicting Device‐Induced Platelet Damage in Assisted Circulation Using a New Biophysical Model and Experimental Validation

Artificial Organs, EarlyView.
Quantitative assessment of a newly proposed CFD‐based biophysical model for predicting device‐induced platelet damage by circulatory assist devices was performed. The new model preserved the relative trends observed previously with the power‐law formulation across a range of clinically relevant pump operating conditions, while demonstrating improved ...
Anik Tarafder, Dong Han, Bartley P. Griffith, Zhongjun J. Wu   +3 more
wiley   +1 more source