Results 21 to 30 of about 6,222 (193)
Discovery of novel GPVI receptor antagonists by structure-based repurposing. [PDF]
PLoS ONE, 2014 Inappropriate platelet aggregation creates a cardiovascular risk that is largely managed with thienopyridines and aspirin. Although effective, these drugs carry risks of increased bleeding and drug 'resistance', underpinning a drive for new antiplatelet ...
Lewis Taylor +6 more
doaj +2 more sources
Comparison of CLEC-2 and GPVI signaling in platelets: the role of adaptor proteins [PDF]
, 2010 GPVI activates platelets through an ITAM pathway by activation of Src and Syk kinases leading to activation of PLC\(_y\)2. CLEC-2 has been shown to activate platelets using an ITAM-like sequence in its cytoplasmic tail that is also dependent on Src and ...
Hughes, Craig Edward
core +7 more sources
GPVI receptor spatial organisation and signalling in platelets [PDF]
, 2020 Platelets are crucial players in many (patho)physiological processes including haemostasis, thrombosis and inflammation. The immunoreceptor tyrosine-based activation motif (ITAM)-containing receptor glycoprotein VI (GPVI) is the major platelet signalling
Pallini, Chiara
core +6 more sources
Phytochemical Profiling, Antiplatelet Potential, and Cytotoxic Assessment of Thymelaea tartonraira Aerial Part Essential Oil: In Vitro and In Silico Studies. [PDF]
Chem BiodiversEssential oil from Thymelaea tartonraira was characterized by GC–MS and evaluated using in vitro and in silico approaches. The oil exhibited notable antiplatelet activity with low cytotoxicity. Molecular docking revealed strong interactions of major compounds with GPVI, COX‐1, and P2Y12, supporting its potential as a natural antiplatelet agent ...
Soltani S +8 more
europepmc +2 more sources
Soluble GPVI is elevated in injured patients: shedding is mediated by fibrin activation of GPVI [PDF]
Blood Advances, 2018 Key Points Soluble GPVI is elevated in patients with thermal injury with sepsis, and sGPVI levels augment severity score prediction of mortality.
Samantha J. Montague +20 more
openaire +6 more sources
Thrombosis and Haemostasis, 2021 AbstractCollagen has been proposed to bind to a unique epitope in dimeric glycoprotein VI (GPVI) and the number of GPVI dimers has been reported to increase upon platelet activation. However, in contrast, the crystal structure of GPVI in complex with collagen-related peptide (CRP) showed binding distinct from the site of dimerization.
Joanne C. Clark +14 more
openaire +3 more sources
mTOR regulates GPVI-mediated platelet activation [PDF]
Journal of Translational Medicine, 2021 Abstract Background Due to mTOR (mammalian/mechanistic target of rapamycin) gene-loss mice die during embryonic development, the role of mTOR in platelets has not been evaluated using gene knockout technology. Methods A mouse model with megakaryocyte/platelet-specific ...
Longsheng Wang +10 more
openaire +3 more sources
Role of focal adhesion tyrosine kinases in GPVI-dependent platelet activation and reactive oxygen species formation. [PDF]
PLoS ONE, 2014 We have previously shown the presence of a TRAF4/p47phox/Hic5/Pyk2 complex associated with the platelet collagen receptor, GPVI, consistent with a potential role of this complex in GPVI-dependent ROS formation.
Naadiya Carrim +5 more
doaj +1 more source
Thrombosis Journal, 2022 Background Continuous agitation during storage slows down the platelet storage lesions. However, in special circumstances, manual-mixing can be alternatively used to store products for short time periods without compromising platelet quality.
Ehteramolsadat Hosseini +4 more
doaj +1 more source
Platelets, 2021 Collagen, the most thrombogenic constituent of blood vessel walls, activates platelets through glycoprotein VI (GPVI). In suspension, following platelet activation by collagen, GPVI is cleaved by A Disintegrin And Metalloproteinase (ADAM)10 and ADAM17 ...
Chiara Pallini +6 more
doaj +1 more source