Results 21 to 30 of about 4,333 (173)

Biomarkers of Cardioembolic Stroke in Thrombus Composition: Diagnostic Value of DNA and Fibrin Content. [PDF]

Eur J Neurol
ABSTRACT Background and Purpose Cryptogenic strokes, accounting for 25%–40% of ischemic strokes, represent a major challenge in secondary prevention due to their uncertain etiology and high recurrence risk. Identifying biomarkers to reliably distinguish cardioembolic (CE) strokes among embolic strokes of undetermined source (ESUS) could help guide ...
Fasille J, Nomenjanahary MS, Faille D, Habay C, Bedoucha L, Kyheng M, Labreuche J, Consoli A, Lapergue B, Piotin M, Blanc R, Ho-Tin-Noé B, Mazighi M, Desilles JP, Di Meglio L, Compo CLOT Study Group.   +15 more
europepmc   +2 more sources

Association between endometriosis, infertility and autoimmune antiplatelet glycoprotein VI antibodies in two patients

Platelets, 2023
The association between endometriosis and autoimmune diseases is well known, however no acquired platelet function defect has been described so far. We describe the case of two patients with endometriosis associated with an antiplatelet glycoprotein VI ...
Stéphane Loyau, Anne Bauters, Nathalie Trillot, Cédric Garcia, Pierre Cougoul, Hélène Pol, Camille Paris, Geoffroy Robin, Chrystèle Rubod, Bernard Payrastre, Martine Jandrot-Perrus, Sophie Voisin, Annabelle Dupont   +12 more
doaj   +1 more source

Clustering of glycoprotein VI (GPVI) dimers upon adhesion to collagen as a mechanism to regulate GPVI signaling in platelets [PDF]

Journal of Thrombosis and Haemostasis, 2017
Essentials - Dimeric high-affinity collagen receptor glycoprotein VI (GPVI) is present on resting platelets. - Spatio-temporal organization of platelet GPVI-dimers was evaluated using advanced microscopy. - Upon platelet adhesion to collagenous substrates, GPVI-dimers coalesce to form clusters.
Poulter, N. S., Pollitt, A. Y., Owen, D. M., Gardiner, E. E., Andrews, R. K., Shimizu, H., Ishikawa, D., Bihan, D., Farndale, R. W., Moroi, M., Watson, S. P., Jung, S. M.   +11 more
openaire   +4 more sources

Targeting GPVI as a novel antithrombotic strategy

Journal of Blood Medicine, 2014
While platelet activation is essential to maintain blood vessel patency and minimize loss of blood upon injury, untimely or excessive activity can lead to unwanted platelet activation and aggregation. Resultant thrombosis has the potential to block blood vessels, causing myocardial infarction or stroke. To tackle this major cause of mortality, clinical
Andrews, Robert K, Arthur, JF, Gardiner, Elizabeth   +2 more
openaire   +7 more sources

Inhibition of Src but not Syk causes weak reversal of GPVI-mediated platelet aggregation measured by light transmission aggregometry

Platelets, 2022
Src tyrosine kinases and spleen tyrosine kinase (Syk) have recently been shown to contribute to sustained platelet aggregation on collagen under arterial shear.
Hilaire Yam Fung Cheung, Luis A. Moran, Albert Sickmann, Johan W.M. Heemskerk, Ángel Garcia, Steve P. Watson   +5 more
doaj   +1 more source

Cross-Linking GPVI-Fc by Anti-Fc Antibodies Potentiates Its Inhibition of Atherosclerotic Plaque- and Collagen-Induced Platelet Activation

JACC: Basic to Translational Science, 2016
To enhance the antithrombotic properties of recombinant glycoprotein VI fragment crystallizable (GPVI-Fc), the authors incubated GPVI-Fc with anti-human Fc antibodies to cross-link the Fc tails of GPVI-Fc.
Janina Jamasbi, RPh, Remco T.A. Megens, PhD, Mariaelvy Bianchini, MSc, Kerstin Uhland, PhD, Götz Münch, MD, Martin Ungerer, MD, Shachar Sherman, BSc, Alexander Faussner, PhD, Richard Brandl, MD, Christine John, MSc, Johannes Buchner, PhD, Christian Weber, MD, Reinhard Lorenz, MD, Natalie Elia, PhD, Wolfgang Siess, MD   +14 more
doaj   +1 more source

Collagen-dependent platelet dysfunction and its relevance to either mitochondrial ROS or cytosolic superoxide generation: a question about the quality and functional competence of long-stored platelets

Thrombosis Journal, 2020
Background Upon vascular damage, the exposed subendothelial matrix recruits circulating platelets to site of injury while inducing their firm adhesion mainly via GPVI-collagen interaction.
Ehteramolsadat Hosseini, Saba Hojjati, Safoora Afzalniaye gashti, Mehran Ghasemzadeh   +3 more
doaj   +1 more source

Anti‐GPVI nanobody blocks collagen‐ and atherosclerotic plaque–induced GPVI clustering, signaling, and thrombus formation

Journal of Thrombosis and Haemostasis, 2022
The collagen receptor glycoprotein VI (GPVI) is an attractive antiplatelet target due to its critical role in thrombosis but minor involvement in hemostasis.To investigate GPVI receptor involvement in platelet activation by collagen-I and atherosclerotic plaque using novel blocking and non-blocking anti-GPVI nanobodies (Nbs).Nb effects on GPVI-mediated
Natalie J. Jooss, Christopher W. Smith, Alexandre Slater, Samantha J. Montague, Ying Di, Christopher O'Shea, Mark R. Thomas, Yvonne M.C. Henskens, Johan W.M. Heemskerk, Steve P. Watson, Natalie S. Poulter   +10 more
openaire   +2 more sources

Structure-function relationship of the platelet glycoprotein VI (GPVI) receptor: does it matter if it is a dimer or monomer?

Platelets, 2021
GPVI is a critical signaling receptor responsible for collagen-induced platelet activation and a promising anti-thrombotic target in conditions such as coronary artery thrombosis, ischemic stroke, and atherothrombosis. This is due to the ability to block
Joanne C. Clark, Foteini-Nafsika Damaskinaki, Yam Fung Hilaire Cheung, Alexandre Slater, Steve P. Watson   +4 more
doaj   +1 more source

Targeting GPVI

, 2023
Platelets are blood cells that prevent the loss of extensive blood volumes, but also contribute to arterial thrombosis. After a vessel is injured, platelets become activated by the exposed collagen and aggregate together, forming a thrombus. Whilst this is a crucial process in hemostasis, platelets also become activated due to rupture of an ...
openaire   +2 more sources