Results 41 to 50 of about 46,379 (251)

Antiplatelet Activity of Tussilagone via Inhibition of the GPVI Downstream Signaling Pathway in Platelets

Frontiers in Medicine, 2020
Tussilagone is a sesquiterpenoid extracted from Tussilago farfara and is used as an oriental medicine for asthma and bronchitis. Although previous studies have shown that tussilagone has an inhibitory effect on platelet aggregation, no studies have been ...
Jing Zhou, Ru-Ping Yang, Wei Song, Hui-Min Xu, Yong-Hui Wang   +4 more
doaj   +1 more source

Enhanced stability of the SARS CoV-2 spike glycoprotein following modification of an alanine cavity in the protein core.

PLoS Pathogens, 2023
The spike (S) glycoprotein of SARS CoV-2 is the target of neutralizing antibodies (NAbs) that are crucial for vaccine effectiveness. The S1 subunit binds ACE2 while the S2 subunit mediates virus-cell membrane fusion.
Pantelis Poumbourios, Christine Langer, Irene Boo, Tasnim Zakir, Rob J Center, Anouschka Akerman, Vanessa Milogiannakis, Anupriya Aggarwal, Bronte A Johnstone, Jungmin Ha, Fasséli Coulibaly, Stuart G Turville, Heidi E Drummer   +12 more
doaj   +1 more source

Collagen can selectively trigger a platelet secretory phenotype via glycoprotein VI. [PDF]

PLoS ONE, 2014
Platelets are not only central actors of hemostasis and thrombosis but also of other processes including inflammation, angiogenesis, and tissue regeneration.
Véronique Ollivier, Varouna Syvannarath, Angèle Gros, Amena Butt, Stéphane Loyau, Martine Jandrot-Perrus, Benoît Ho-Tin-Noé   +6 more
doaj   +1 more source

Glycoprotein VI oligomerization in cell lines and platelets [PDF]

Journal of Thrombosis and Haemostasis, 2007
Glycoprotein VI (GPVI) is a physiologic receptor for collagen expressed at the surface of platelets and megakaryocytes. Constitutive dimerization of GPVI has been proposed as being necessary for the interaction with collagen, although direct evidence of dimerization has not been reported in cell lines or platelets.To investigate oligomerization of GPVI
Berlanga, O, Bori-Sanz, T, James, JR, Frampton, J, Davis, S, Tomlinson, MG, Watson, S   +6 more
openaire   +3 more sources

Atroxlysin-III, A Metalloproteinase from the Venom of the Peruvian Pit Viper Snake Bothrops atrox (Jergón) Induces Glycoprotein VI Shedding and Impairs Platelet Function

Molecules, 2019
Atroxlysin-III (Atr-III) was purified from the venom of Bothrops atrox. This 56-kDa protein bears N-linked glycoconjugates and is a P-III hemorrhagic metalloproteinase.
Luciana S. Oliveira, Maria Inácia Estevão-Costa, Valéria G. Alvarenga, Dan E. Vivas-Ruiz, Armando Yarleque, Augusto Martins Lima, Ana Cavaco, Johannes A. Eble, Eladio F. Sanchez   +8 more
doaj   +1 more source

An optimized herbal medicine containing Scutellaria baicalensis Georgi, Alisma orientale Juzepzuk, and Atractylodes japonica Koidzumi has potent antiplatelet and antithrombotic activities

Journal of Traditional and Complementary Medicine, 2023
Background and aim: Platelet-derived thrombosis is important in the pathogenesis of cardiovascular diseases. HTB is an optimized herbal medicine including Scutellaria baicalensis Georgi, Alisma orientale Juzepzuk, and Atractylodes japonica Koidzumi.
Yeon-Ji Kim, Tae In Kim, Kyungho Kim
doaj   +1 more source

Cross-Linking GPVI-Fc by Anti-Fc Antibodies Potentiates Its Inhibition of Atherosclerotic Plaque- and Collagen-Induced Platelet Activation

JACC: Basic to Translational Science, 2016
To enhance the antithrombotic properties of recombinant glycoprotein VI fragment crystallizable (GPVI-Fc), the authors incubated GPVI-Fc with anti-human Fc antibodies to cross-link the Fc tails of GPVI-Fc.
Janina Jamasbi, RPh, Remco T.A. Megens, PhD, Mariaelvy Bianchini, MSc, Kerstin Uhland, PhD, Götz Münch, MD, Martin Ungerer, MD, Shachar Sherman, BSc, Alexander Faussner, PhD, Richard Brandl, MD, Christine John, MSc, Johannes Buchner, PhD, Christian Weber, MD, Reinhard Lorenz, MD, Natalie Elia, PhD, Wolfgang Siess, MD   +14 more
doaj   +1 more source

Polymerized fibrin activates glycoprotein VI [PDF]

Blood, 2015
In this issue of Blood , [Mammadova-Bach et al][1] show that polymerized fibrin binds to the platelet receptor glycoprotein VI (GPVI), amplifying thrombin generation and enhancing thrombus growth.[1][2] ![Figure][3] GPVI amplifies thrombin generation and platelet aggregation. PS,
openaire   +2 more sources

Platelet glycoprotein VI‐related clinical defects [PDF]

British Journal of Haematology, 2007
SummaryHuman patients with defects associated with the platelet collagen receptor, glycoprotein (GP)VI, are rare and usually described as having a mild bleeding disorder. However, here we review clinical profiles of patients with familial or acquired GPVI defects, revealing the bleeding defect is often severe and associated with immune dysfunction ...
Jane F, Arthur, Scott, Dunkley, Robert K, Andrews   +2 more
openaire   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source