Results 41 to 50 of about 43,195 (149)

Cross-Linking GPVI-Fc by Anti-Fc Antibodies Potentiates Its Inhibition of Atherosclerotic Plaque- and Collagen-Induced Platelet Activation

JACC: Basic to Translational Science, 2016
To enhance the antithrombotic properties of recombinant glycoprotein VI fragment crystallizable (GPVI-Fc), the authors incubated GPVI-Fc with anti-human Fc antibodies to cross-link the Fc tails of GPVI-Fc.
Janina Jamasbi, RPh, Remco T.A. Megens, PhD, Mariaelvy Bianchini, MSc, Kerstin Uhland, PhD, Götz Münch, MD, Martin Ungerer, MD, Shachar Sherman, BSc, Alexander Faussner, PhD, Richard Brandl, MD, Christine John, MSc, Johannes Buchner, PhD, Christian Weber, MD, Reinhard Lorenz, MD, Natalie Elia, PhD, Wolfgang Siess, MD   +14 more
doaj   +1 more source

Biomechanical thrombosis: the dark side of force and dawn of mechano-medicine

Stroke and Vascular Neurology, 2020
Arterial thrombosis is in part contributed by excessive platelet aggregation, which can lead to blood clotting and subsequent heart attack and stroke. Platelets are sensitive to the haemodynamic environment.
Yunfeng Chen, Lining Arnold Ju
doaj   +1 more source

Restrained glycoprotein VI-induced platelet signaling by tyrosine protein phosphatases independent of phospholipase Cγ2

Bleeding, Thrombosis and Vascular Biology, 2023
The platelet collagen receptor glycoprotein VI (GPVI) signals to activation of phospholipase Cγ2 (PLCγ2) and phosphoinositide 3-kinases (PI3K), causing platelet activation and aggregation.
Jingnan Huang, Delia I. Fernández, Jinmi Zou, Xueqing Wang, Johan W.M. Heemskerk, Ángel García   +5 more
doaj   +1 more source

Detection and first characterization of an uncommon haptoglobin in porcine saliva of pigs with rectal prolapse by using boronic acid sample enrichment

Animal, 2017
Salivary glycoprotein profiles, obtained after boronic acid enrichment, were studied for the first time in pigs in order to search for specific overall alterations related to acute inflammatory condition.
A.M. Gutiérrez, I. Miller, D. Kolarich, K. Hummel, K. Nöbauer, E. Razzazi-Fazeli   +5 more
doaj   +1 more source

Influence of Vincristine, Clinically Used in Cancer Therapy and Immune Thrombocytopenia, on the Function of Human Platelets

Molecules, 2021
Vincristine is a clinically used antimicrotubule drug for treating patients with lymphoma. Due to its property of increasing platelet counts, vincristine is also used to treat patients with immune thrombocytopenia.
Li-Ming Lien, Wan-Jung Lu, Kuan-Hung Lin, Ling-Hsuan Kang, Ting-Yu Chen, Bo-Jung Lin, Yung-Chang Lu, Chun-Yao Huang, Chun-Ming Shih, Hsuan Chen, Yao-Chou Tsai, Ray-Jade Chen, Joen-Rong Sheu   +12 more
doaj   +1 more source

CLP36 Is a Negative Regulator of Glycoprotein VI Signaling in Platelets [PDF]

Circulation Research, 2012
Rationale: At sites of vascular injury, exposed subendothelial collagens not only trigger sudden platelet adhesion and aggregation, thereby initiating normal hemostasis, but also can lead to acute ischemic diseases, such as myocardial infarction or stroke. The glycoprotein (GP) VI/Fc receptor γ-chain
Shuchi, Gupta, Attila, Braun, Martina, Morowski, Thomas, Premsler, Markus, Bender, Zoltan, Nagy, Albert, Sickmann, Heike M, Hermanns, Michael, Bösl, Bernhard, Nieswandt   +9 more
openaire   +2 more sources

Thymosin β4 is essential for thrombus formation by controlling the G-actin/F-actin equilibrium in platelets

Haematologica, 2021
Coordinated rearrangements of the actin cytoskeleton are pivotal for platelet biogenesis from megakaryocytes but also orchestrate key functions of peripheral platelets in hemostasis and thrombosis, such as granule release, the formation of filopodia and
Inga Scheller, Sarah Beck, Vanessa Göb, Carina Gross, Raluca A. I. Neagoe, Katja Aurbach, Markus Bender, David Stegner, Zoltan Nagy, Bernhard Nieswandt   +9 more
doaj   +1 more source

Expression of glycoprotein VI in vascular endothelial cells

Platelets, 2003
Glycoprotein (GP) VI, a collagen receptor, plays a important role in collagen-mediated platelet aggregation and adhesion. To date, GPVI expression has been found only in platelets and megakaryocytes. In the present studies, we have demonstrated that GPVI was also expressed in cultured human umbilical vein endothelial cells (HUVEC) at both transcript ...
Bing, Sun, Lian, Tao, Shihua, Lin, Noel Y, Calingasan, Jess, Li, Narendra N, Tandon, Masuhiro, Yoshitake, Jun-Ichi, Kambayashi   +7 more
openaire   +3 more sources

Selective Blockade of Glycoprotein VI Clustering on Collagen Helices [PDF]

Journal of Biological Chemistry, 2006
Platelet activation by collagen relies on the interaction of the receptor glycoprotein VI (GPVI) with collagen helices. We have previously generated two recombinant single chain human antibodies (scFvs) to human GPVI. The first, 10B12, binds to the collagen-binding site on the apical surface between the two immunoglobulin-like domains (D1D2) of the ...
Marie N, O'Connor, Peter A, Smethurst, Lorna W, Davies, Lotta, Joutsi-Korhonen, David J, Onley, Andrew B, Herr, Richard W, Farndale, Willem H, Ouwehand   +7 more
openaire   +2 more sources

Beyond antiplatelets: The role of glycoprotein VI in ischemic stroke [PDF]

International Journal of Stroke, 2016
Background Platelets are essential to physiological hemostasis or pathological thrombus formation. Current antiplatelet agents inhibit platelet aggregation but leave patients at risk of systemic side-effects such as hemorrhage.
Induruwa, Isuru, Jung, Stephanie M, Warburton, Elizabeth A   +2 more
openaire   +2 more sources