Results 21 to 30 of about 43,195 (149)

Variation in Human Platelet Glycoprotein VI Content Modulates Glycoprotein VI–Specific Prothrombinase Activity [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2001
Glycoprotein VI (GPVI) is a platelet-specific receptor for collagen that figures prominently in signal transduction. An addition to binding to type I and III collagens, GPVI is also bound specifically by collagen-related peptide and convulxin (CVX), a snake venom protein.
Furihata, K, Clemetson, Kenneth John, Deguchi, H, Kunicki, TJ   +3 more
openaire   +4 more sources

Absence of bleeding upon dual antiplatelet therapy in a patient with a immune GPVI deficiency

Platelets, 2021
Acquired deficiencies in platelet glycoprotein VI are rare and have not been found associated with other defects. Here we report the case of a 64-year old male patient presenting an immune GPVI deficiency associated to a mutation in the alpha-actinin ...
Stéphane Loyau Inserm, Dorothée Faille, Philippe Gautier, Paquita Nurden, Martine Jandrot-Perrus, Nadine Ajzenberg   +5 more
doaj   +1 more source

Efficient inhibition of collagen-induced platelet activation and adhesion by LAIR-2, a soluble Ig-like receptor family member. [PDF]

PLoS ONE, 2010
LAIR-1 (Leukocyte Associated Ig-like Receptor -1) is a collagen receptor that functions as an inhibitory receptor on immune cells. It has a soluble family member, LAIR-2, that also binds collagen and can interfere with LAIR-1/collagen interactions ...
Peter J Lenting, Geertje H A Westerlaken, Cécile V Denis, Jan Willem Akkerman, Linde Meyaard   +4 more
doaj   +1 more source

Differential effects of reduced glycoprotein VI levels on activation of murine platelets by glycoprotein VI ligands [PDF]

Biochemical Journal, 2002
We have investigated the effects of decreased levels of the complex between glycoprotein VI (GPVI) and the Fc receptor γ-chain (FcRγ) on responses to collagen and GPVI-specific ligands in murine platelets. We show that levels of GPVI—FcRγ of the order of 50% and 20% of wild-type levels caused 2- and 5-fold shifts to the right respectively in the dose ...
Snell, D.C., Schulte, V., Jarvis, Gavin, Arase, K., Sakurai, D., Saito, T., Watson, S.P., Nieswandt, B.   +7 more
openaire   +2 more sources

Association between endometriosis, infertility and autoimmune antiplatelet glycoprotein VI antibodies in two patients

Platelets, 2023
The association between endometriosis and autoimmune diseases is well known, however no acquired platelet function defect has been described so far. We describe the case of two patients with endometriosis associated with an antiplatelet glycoprotein VI ...
Stéphane Loyau, Anne Bauters, Nathalie Trillot, Cédric Garcia, Pierre Cougoul, Hélène Pol, Camille Paris, Geoffroy Robin, Chrystèle Rubod, Bernard Payrastre, Martine Jandrot-Perrus, Sophie Voisin, Annabelle Dupont   +12 more
doaj   +1 more source

Glycoprotein VI interplay with fibrin(ogen) in thrombosis

Journal of Thrombosis and Haemostasis, 2023
Platelets play a central role in the arrest of bleeding. The ability of platelets to engage with extracellular matrix proteins of the subendothelium has long been recognized as a pivotal platelet attribute, underpinning adequate hemostasis. The propensity of platelets to rapidly bind and functionally respond to collagen was one of the earliest ...
Pierre H, Mangin, Elizabeth E, Gardiner, Robert A S, Ariëns, Martine, Jandrot-Perrus   +3 more
openaire   +2 more sources

Glycoprotein VI oligomerization in cell lines and platelets [PDF]

Journal of Thrombosis and Haemostasis, 2007
Glycoprotein VI (GPVI) is a physiologic receptor for collagen expressed at the surface of platelets and megakaryocytes. Constitutive dimerization of GPVI has been proposed as being necessary for the interaction with collagen, although direct evidence of dimerization has not been reported in cell lines or platelets.To investigate oligomerization of GPVI
Berlanga, O, Bori-Sanz, T, James, JR, Frampton, J, Davis, S, Tomlinson, MG, Watson, S   +6 more
openaire   +3 more sources

Ibrutinib-associated alveolar hemorrhage and spontaneous hemothorax

Polish Journal of Thoracic and Cardiovascular Surgery, 2022
Ibrutinib is an irreversible inhibitor of Bruton’s tyrosine kinase (BTK), a cytoplasmic tyrosine kinase of the Tec family, which plays an important role in the B-cell receptor signaling pathway [1].
Ismail Tombul, Muhammet Sayan, Nazlihan Dundar, Asena Dikyar, Seyma Yildiz, Ali Celik   +5 more
doaj   +1 more source

Co-expression of the collagen receptors leukocyte-associated immunoglobulin-like receptor-1 and glycoprotein VI on a subset of megakaryoblasts

Haematologica, 2010
Background The collagen receptor glycoprotein VI generates activating signals through an immunoreceptor tyrosine-based activating motif on the co-associated Fc receptor gamma chain.
Tessa A.M. Steevels, Geertje H.A. Westerlaken, Marloes R. Tijssen, Paul J. Coffer, Peter J. Lenting, Jan Willem N. Akkerman, Linde Meyaard   +6 more
doaj   +1 more source

Platelet glycoprotein VI‐related clinical defects [PDF]

British Journal of Haematology, 2007
SummaryHuman patients with defects associated with the platelet collagen receptor, glycoprotein (GP)VI, are rare and usually described as having a mild bleeding disorder. However, here we review clinical profiles of patients with familial or acquired GPVI defects, revealing the bleeding defect is often severe and associated with immune dysfunction ...
Jane F, Arthur, Scott, Dunkley, Robert K, Andrews   +2 more
openaire   +2 more sources