Results 21 to 30 of about 45,521 (251)

Association between endometriosis, infertility and autoimmune antiplatelet glycoprotein VI antibodies in two patients

Platelets, 2023
The association between endometriosis and autoimmune diseases is well known, however no acquired platelet function defect has been described so far. We describe the case of two patients with endometriosis associated with an antiplatelet glycoprotein VI ...
Stéphane Loyau, Anne Bauters, Nathalie Trillot, Cédric Garcia, Pierre Cougoul, Hélène Pol, Camille Paris, Geoffroy Robin, Chrystèle Rubod, Bernard Payrastre, Martine Jandrot-Perrus, Sophie Voisin, Annabelle Dupont   +12 more
doaj   +1 more source

Variation in Human Platelet Glycoprotein VI Content Modulates Glycoprotein VI–Specific Prothrombinase Activity [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2001
Glycoprotein VI (GPVI) is a platelet-specific receptor for collagen that figures prominently in signal transduction. An addition to binding to type I and III collagens, GPVI is also bound specifically by collagen-related peptide and convulxin (CVX), a snake venom protein.
Furihata, K, Clemetson, Kenneth John, Deguchi, H, Kunicki, TJ   +3 more
openaire   +4 more sources

Ibrutinib-associated alveolar hemorrhage and spontaneous hemothorax

Polish Journal of Thoracic and Cardiovascular Surgery, 2022
Ibrutinib is an irreversible inhibitor of Bruton’s tyrosine kinase (BTK), a cytoplasmic tyrosine kinase of the Tec family, which plays an important role in the B-cell receptor signaling pathway [1].
Ismail Tombul, Muhammet Sayan, Nazlihan Dundar, Asena Dikyar, Seyma Yildiz, Ali Celik   +5 more
doaj   +1 more source

Co-expression of the collagen receptors leukocyte-associated immunoglobulin-like receptor-1 and glycoprotein VI on a subset of megakaryoblasts

Haematologica, 2010
Background The collagen receptor glycoprotein VI generates activating signals through an immunoreceptor tyrosine-based activating motif on the co-associated Fc receptor gamma chain.
Tessa A.M. Steevels, Geertje H.A. Westerlaken, Marloes R. Tijssen, Paul J. Coffer, Peter J. Lenting, Jan Willem N. Akkerman, Linde Meyaard   +6 more
doaj   +1 more source

Differential effects of reduced glycoprotein VI levels on activation of murine platelets by glycoprotein VI ligands [PDF]

Biochemical Journal, 2002
We have investigated the effects of decreased levels of the complex between glycoprotein VI (GPVI) and the Fc receptor γ-chain (FcRγ) on responses to collagen and GPVI-specific ligands in murine platelets. We show that levels of GPVI—FcRγ of the order of 50% and 20% of wild-type levels caused 2- and 5-fold shifts to the right respectively in the dose ...
Snell, D.C., Schulte, V., Jarvis, Gavin, Arase, K., Sakurai, D., Saito, T., Watson, S.P., Nieswandt, B.   +7 more
openaire   +2 more sources

The relationship between platelet glycoprotein VI T13254C polymorphism and acute myocardial infarction (MI) [PDF]

پیاورد سلامت, 2011
Background and Aim: Myocardial infarction (MI) is a major cause of morbidity and mortality worldwide. Epidemiological studies indicate that MI results from complex interactions between long-term environmental influences, concomitant disorders, and ...
A Fatemi, A Kazemi, MM Peighambari, N Givtaj, H Bakhshandeh   +4 more
doaj   +1 more source

Increased platelet reactivity as measured by plasma glycoprotein VI in gout

Platelets, 2018
Patients with gout have an increased risk of cardiovascular events. The glycoprotein VI (GPVI) receptor is found exclusively on platelets and megakaryocytes, is proteolytically cleaved upon platelet activation, and detectable in plasma as soluble GPVI ...
Richard Conway, Claire-Louise Murphy, Anne Madigan, Patricia Kavanagh, Liz Geraghty, Niamh Redmond, Laura Helbert, John J. Carey, Eimear Dunne, Dermot Kenny, Geraldine M. McCarthy   +10 more
doaj   +1 more source

Sanguinarine Attenuates Collagen-Induced Platelet Activation and Thrombus Formation

Biomedicines, 2021
Sanguinarine, a benzophenanthridine alkaloid, has been described to have an antiplatelet activity. However, its antithrombotic effect and the mechanism of platelet inhibition have not thoroughly been explored.
Dan Shu, Ying Zhu, Meng Lu, Ao-Di He, Jiang-Bin Chen, Ding-Song Ye, Yue Liu, Xiang-Bin Zeng, Rong Ma, Zhang-Yin Ming   +9 more
doaj   +1 more source

Posttranslational modifications of platelet adhesion receptors

Pharmacological Research, 2022
Platelets play a key role in normal hemostasis, whereas pathological platelet adhesion is involved in various cardiovascular events. The underlying cause in cardiovascular events involves plaque rupture leading to subsequent platelet adhesion, activation,
Shukun Sun, Bao Qiao, Yu Han, Bailu Wang, Shujian Wei, Yuguo Chen   +5 more
doaj   +1 more source

Glycoprotein VI interplay with fibrin(ogen) in thrombosis

Journal of Thrombosis and Haemostasis, 2023
Platelets play a central role in the arrest of bleeding. The ability of platelets to engage with extracellular matrix proteins of the subendothelium has long been recognized as a pivotal platelet attribute, underpinning adequate hemostasis. The propensity of platelets to rapidly bind and functionally respond to collagen was one of the earliest ...
Pierre H, Mangin, Elizabeth E, Gardiner, Robert A S, Ariëns, Martine, Jandrot-Perrus   +3 more
openaire   +2 more sources