Results 211 to 220 of about 7,185 (234)
Western Diet Modifies Platelet Activation Profiles in Male Mice. [PDF]
Int J Mol SciCorken A, Wahl EC, Sikes JD, Thakali KM.
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Restraining of glycoprotein VI- and integrin α2β1-dependent thrombus formation by platelet PECAM1. [PDF]
Cell Mol Life SciJooss NJ +10 more
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A GPVI signalling defect in newly formed platelets generated in stress thrombopoiesis
Stephanie R. Hyslop +11 more
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A novel technique to characterize procoagulant platelet formation and evaluate platelet procoagulant tendency in cats by flow cytometry. [PDF]
Front Vet SciShaverdian M, Nguyen N, Li RHL.
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GPVI and the not so eager cleaver [PDF]
Blood, 2010 Platelets control their responsiveness, in part, by shedding adhesion and signaling receptors from their surface. The molecular mechanism by which this occurs, however,is incompletely understood. In this issue of Blood, Bender and colleagues make judicious use of mice genetically deficient in selected candidate proteases to shed new light on the ...
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The Journal of Pharmacology and Experimental Therapeutics, 2012
Glycoprotein VI (GPVI) has been proposed as a promising antiplatelet target, because its blockade prevents experimental thrombosis without impairing hemostasis. The objective of this study was to develop a preclinical tool to evaluate the role of human GPVI (hGPVI) in various models of thrombosis and to screen anti-GPVI compounds.
P. H. Mangin +7 more
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Glycoprotein VI (GPVI) has been proposed as a promising antiplatelet target, because its blockade prevents experimental thrombosis without impairing hemostasis. The objective of this study was to develop a preclinical tool to evaluate the role of human GPVI (hGPVI) in various models of thrombosis and to screen anti-GPVI compounds.
P. H. Mangin +7 more
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Blood, 2009
The search is on for natural regulators of platelet reactivity. In this issue of Blood, Trifiro and colleagues confirm that the low frequency isoform of platelet GPVI (VIb) attenuates ligand-mediated signal transduction and dampens down platelet reactivity with collagen while not affecting GPVI receptor copy number.
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The search is on for natural regulators of platelet reactivity. In this issue of Blood, Trifiro and colleagues confirm that the low frequency isoform of platelet GPVI (VIb) attenuates ligand-mediated signal transduction and dampens down platelet reactivity with collagen while not affecting GPVI receptor copy number.
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Platelet GPVI: a target for antithrombotic therapy?!
Trends in Pharmacological Sciences, 2012Platelet activation is a key step in the pathogenesis of ischemic cardio- and cerebrovascular diseases, which represent the leading causes of death and severe disability worldwide. Although existing antiplatelet drugs have proved beneficial in the clinic, their use is limited by their inherent effect on primary hemostasis, making the identification of ...
Markus Bender +2 more
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Generation of Transgenic Mice for Platelet-Specific Expression of Human GPVI From GPVI-Knockout Mice
Blood, 2011Abstract Abstract 1139 Transgenic mice with human gene knock-in (KI) in platelets can be very useful tools for the evaluation of anti-thrombotic therapeutics in vivo, as many murine thrombosis models have been established and well-characterized.
Yan Zhang +5 more
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