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GPVI: no magic bullet for thrombosis
Blood, 2006Comment on Mangin et al, page The platelet collagen receptor GPVI has been considered an attractive therapeutic target to treat human cardiovascular diseases. An article by Mangin and colleagues in this issue of Blood reveals that loss of GPVI does not produce the expected dramatic effect on arterial thrombosis in mice.
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Highly potent anti-human GPVI monoclonal antibodies derived from GPVI knockout mouse immunization
Thrombosis Research, 2007Recent progress in the understanding of thrombus formation has suggested an important role for glycoprotein (GP) VI in this process. To clarify the exact role in detail, it is necessary to use specific, high affinity inhibitory antibodies. However, possibly due to the conserved structure of GPVI among species, it has been difficult to obtain potent ...
Simon Lockyer +9 more
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Tec regulates platelet activation by GPVI in the absence of Btk [PDF]
Blood, 2003 AbstractThe Tec family kinase Btk plays an important role in the regulation of phospholipase Cγ2 (PLCγ2) downstream of the collagen receptor glycoprotein VI (GPVI) in human platelets. Platelets also express a second member of this family, Tec; however, its function has not been analyzed.
Steve P. Watson +4 more
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Platelet Activation through GPVI Receptor: Variability of the Response
Biochemistry (Moscow), Supplement Series A: Membrane and Cell Biology, 2021Platelets are nuclear-free cell fragments responsible for preventing blood loss in case of the vascular wall injury. After a contact with collagen exposed when the vessel is damaged, platelets become activated through the receptor glycoprotein GPVI. This leads to platelet shape change, degranulation, aggregation, and procoagulant responses.
A. N. Sveshnikova +4 more
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Thrombosis and Haemostasis, 2009
SummaryThe Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, CD147, basigin) is an immunoglobulin-like receptor expressed in various cell types. During cellular interactions homotypic EMMPRIN-EMMPRIN interactions are known to induce the synthesis of matrix metalloproteinases. Recently, we have identified EMMPRIN as a novel receptor on platelets.
Oliver Borst +14 more
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SummaryThe Extracellular Matrix Metalloproteinase Inducer (EMMPRIN, CD147, basigin) is an immunoglobulin-like receptor expressed in various cell types. During cellular interactions homotypic EMMPRIN-EMMPRIN interactions are known to induce the synthesis of matrix metalloproteinases. Recently, we have identified EMMPRIN as a novel receptor on platelets.
Oliver Borst +14 more
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FcRγ-Chain Signals in GPVI-Deficient Platelets.
Blood, 2005Abstract The receptor glycoprotein VI (GPVI) is required for hemostasis and collagen-induced platelet aggregation. GPVI and FcRγ-chain form a noncovalent signaling complex. Genetic ablation of murine FcRγ-chain prevents expression of GPVI, and immunodepletion of GPVI removes FcRγ chain from platelet membranes.
Carl W. Jackson +3 more
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GPVI and collagen: the final word?
Blood, 2022Alexandre Slater, Martine Jandrot-Perrus
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DAPT and GPVI: an antiplatelet triple threat
Journal of Thrombosis and Haemostasis, 2023Andrew, Rickenberg, Michael, Holinstat
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New role for the GPVI/FcRγ chain complex
Blood, 2006Comment on Inoue et al, page [1405][1] Previously thought to function only in collagen-induced platelet activation, Inoue and colleagues report that the GPVI/FcRγ chain complex is a crucial component in relaying activation signals following platelet exposure to the extracellular matrix ...
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