Results 311 to 320 of about 29,098 (325)

SMG9 drives ferroptosis by directly inhibiting GPX4 degradation

Biochemical and Biophysical Research Communications, 2021
Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that plays an integral role in eliminating abnormal mRNA and corresponding proteins. It is unclear whether the NMD pathway is involved in regulating ferroptosis, which is a type of iron-dependent cell death mainly caused by the inhibition of the antioxidant SLC7A11-GPX4 axis.
Leng Han, Lulu Bai, Xue Fang, Jiao Liu, Rui Kang, Di Zhou, Daolin Tang, Enyong Dai   +7 more
openaire   +3 more sources

Role of GPX4 in ferroptosis and its pharmacological implication

Free Radical Biology and Medicine, 2019
Ferroptosis is a non-apoptotic form of cell death characterized by iron-dependent lipid peroxidation and metabolic constraints. Dependence on NADPH/H+, polyunsaturated fatty acid metabolism, and the mevalonate and glutaminolysis metabolic pathways have been implicated in this novel form of regulated necrotic cell death.
Tobias Seibt, Bettina Proneth, Marcus Conrad   +2 more
openaire   +3 more sources

Function and regulation of GPX4 in the development and progression of fibrotic disease

Journal of Cellular Physiology, 2022
AbstractFibrosis is a common feature of fibrotic diseases that poses a serious threat to global health due to high morbidity and mortality in developing countries. There exist some chemical compounds and biomolecules associated with the development of fibrosis, including cytokines, hormones, and enzymes.
Zhaobing Li, Zigui Zhu, Yulu Liu, Yannan Liu, Hong Zhao   +4 more
openaire   +2 more sources

GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2023
Glutathione peroxidase 4 (GPx4) moonlights as structural protein and antioxidase that powerfully inhibits lipid oxidation. In the past years, it is considered as a key regulator of ferroptosis, which takes role in the lipid and amine acid metabolism and influences the cell aging, oncogenesis, and cell death.
Yi, Liu, Yicong, Wan, Yi, Jiang, Lin, Zhang, Wenjun, Cheng   +4 more
openaire   +2 more sources

Redox homeostasis maintained by GPX4 facilitates STING activation

Nature Immunology, 2020
Stimulator-of-interferon genes (STING) is vital for sensing cytosolic DNA and initiating innate immune responses against microbial infection and tumors. Redox homeostasis is the balance of oxidative and reducing reactions present in all living systems. Yet, how the intracellular redox state controls STING activation is unclear.
Jan Rehwinkel, Wenwen Wang, Wenwen Wang, Jinming Yu, Lin Lv, Lin Lv, Wei Zhao, Wei Zhao, Mutian Jia, Mutian Jia, Yuanyuan Wang, Yuanyuan Wang, Li Tong, Li Tong, Chunyuan Zhao, Zhongxia Yu, Zhongxia Yu, Danhui Qin, Danhui Qin, Li Chai, Li Chai   +20 more
openaire   +3 more sources

Mouse Models for Glutathione Peroxidase 4 (GPx4) [PDF]

, 2011
The selenoperoxidase glutathione peroxidase 4 (GPx4 – also frequently referred to as phospholipid hydroperoxide glutathione peroxidase, PHGPx) is one of the eight glutathione peroxidases in mammals, but the only one known to be essential for early mouse development.
openaire   +2 more sources

Targeting GPX4 palmitoylation to boost antitumor immunity

Trends in Cancer
Despite significant milestones in cancer immunotherapy, tumor cells often escape immune surveillance. Zhou et al. revealed that the pivotal ferroptosis suppressor glutathione peroxidase 4 (GPX4) can undergo palmitoylation by zDHHC8, enhancing ferroptosis resistance.
Daehee Hwang, Whitney S. Henry
openaire   +2 more sources

Selenium affects the expression of GPx4 and catalase in the liver of chicken

Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology, 2010
A total of 128 chickens (Gallus gallus, broilers) were used to investigate the effect of organic selenium (Se) in expression of catalase (CAT) and phospholipid hydroperoxidase 4 (GPx4) genes. There were 4 replicates of 4 dietary treatments: T1 (basal diet with no added Se), T2 (T1 with 0.15 ppm Se added), T3 (T1 with 0.3 ppm Se) and T4 (T1 with 3.0 ppm
Constantinos A. Georgiou, Epsilon Komaitis, Evangelos Zoidis, Athanasios C. Pappas, Kostas Feggeros   +4 more
openaire   +3 more sources

Lipid peroxidation and GPx4: the players of the oxygen paradox

Free Radical Biology and Medicine, 2018
Ferroptosis recapitulates the history of oxygen toxicity and lipid peroxidation. Ferroptosis is involved in degenerative diseases and is proposed as a relevant mechanism of onco-suppression. Oxygen, polyunsaturated fatty acids, iron from a labile pool, and seemingly a lipoxygenase are all required for lipid peroxidation that can only take place in the ...
Mattia Zaccarin, Rina Venerando, Antonella Roveri, Matilde Maiorino, Maria Luisa Di Paolo, Giovanni Miotto, Valentina Bosello-Travain, Giorgio Cozza, Stefano Toppo, Monica Rossetto, Ana-Marija Vučković, Fulvio Ursini   +11 more
openaire   +2 more sources

Unraveling Masked GPX4 Inhibitors

Synfacts, 2020
Alexander J. E. Novak, Dirk Trauner
openaire   +2 more sources