Results 321 to 325 of about 29,098 (325)
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Cell Death & Differentiation
Emerging evidence indicates that activation of ferroptosis by inhibition of glutathione peroxidase 4 (GPX4) may be exploited as a therapeutic strategy to suppress tumor growth and progression. However, application of GPX4 inhibitors in cancer treatment is hampered by their poor selectivity, which results in unfavorable toxicity.
Rong Gong +13 more
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Emerging evidence indicates that activation of ferroptosis by inhibition of glutathione peroxidase 4 (GPX4) may be exploited as a therapeutic strategy to suppress tumor growth and progression. However, application of GPX4 inhibitors in cancer treatment is hampered by their poor selectivity, which results in unfavorable toxicity.
Rong Gong +13 more
openaire +2 more sources
An overview of GPX4-targeting TPDs for cancer therapy
Bioorganic & Medicinal ChemistryFerroptosis is a newly identified form of regulated, non-apoptotic cell death caused by iron-dependent phospholipid peroxidation. Glutathione peroxidase 4 (GPX4) inactivation-induced ferroptosis is an efficient antitumor treatment. Currently, several GPX4 inhibitors have been identified.
Xiaojuan, Yang +2 more
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Interfering with GPX4 degradation
Nature Chemical BiologyJing Li, Yuhan Zhou, Weimin Wang
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GPX4 methylation puts a brake on ferroptosis
Nature Cell BiologyGraeme I. Lancaster, Andrew J. Murphy
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Development of cortical interneurons depends on the selenoenzyme GPx4
GBM Annual Spring meeting Mosbach 2009, 2009openaire +2 more sources