Results 21 to 30 of about 120,442 (145)

Preclinical pharmacology and safety studies to support an AAV9 NGLY1 gene therapy clinical trial for the treatment of NGLY1 deficiency

Molecular Therapy: Methods & Clinical Development
GS-100 is an AAV9 gene replacement therapy for the treatment of N-glycanase 1 (NGLY1) deficiency, an ultra-rare, recessive disorder characterized by developmental delay, intellectual disability, hyperkinetic movement disorder, elevated liver enzymes ...
Lei Zhu, Jennifer W. Cook, Alicia Newton, Selina S. Dwight, Brendan Beahm, Matt Wilsey, William F. Mueller, Becky Schweighardt   +7 more
doaj   +1 more source

Giant Amoebic Liver Abscess: A Rare Diagnosis in a Rural Setting of Sub-Saharan Africa

Journal of Parasitology Research, 2021
Background. Extraintestinal amoebiasis is an uncommon complication of Entamoeba histolytica infection, occurring in about 5-10% of patient. Prompt diagnosis and management is essential to prevent complications.
Cyril Jabea Ekabe, Jules Kehbila, Njinju Asaba Clinton   +2 more
doaj   +1 more source

Can Lenalidomide Protect against Severe COVID-19 Symptoms in Multiple Myeloma Patients? A Case Series and Review of the Literature

European Journal of Case Reports in Internal Medicine, 2022
We present a case series of three multiple myeloma (MM) patients on lenalidomide for maintenance therapy who were at high risk of coronavirus disease 2019 (COVID-19) complications and mortality.
Ali Al Sbihi, Nouraldeen Manasrah, Dahlia Sano   +2 more
doaj   +1 more source

The Healthcare Amyloidosis European Registry (HEAR): design of a national registry with a European extension strategy, and foundation of the F-CRIN GRACE network

Orphanet Journal of Rare Diseases
Background Cardiac amyloidosis (CA) is a rare disease that can lead to poor quality of life, conduction disorders, arrhythmia, heart failure, and even death.
Patricia Réant, Mounira Kharoubi, Erwan Donal, Fabrice Bauer, Mélanie Bézard, Arnaud Bisson, Diane Bodez, Océane Bouchot, Eve Cariou, Phillipe Charron, Jérôme Costa, Pierre-Yves Courand, Charlotte Dagrenat, Francois Delelis, Antoine Jobbe Duval, Jean-Christophe Eicher, Antoine Fraix, Barnabas Gellen, Jean-Pierre Gueffet, Damien Guijarro, Gilbert Habib, Albert Hagège, Olivier Huttin, Arnaud Jaccard, Julien Jeanneteau, Damien Legallois, Damien Logeart, Lise Legrand, Jocelyn Inamo, Léa Marguerit, Raphaël Mirailles, Théo Pezel, Nicolas Piriou, Francois Roubille, Basile Mouhat, Romain Trésorier, Jean-Jacques Von Hunolstein, Charles Taieb, Muriel Salvat, Amira Zaroui, Olivier Lairez, Thibaud Damy   +41 more
doaj   +1 more source

Assessing the Efficacy of Radioactive Iodine Seed Localisation in Targeted Axillary Dissection for Node-Positive Early Breast Cancer Patients Undergoing Neoadjuvant Systemic Therapy: A Systematic Review and Pooled Analysis

Diagnostics
Targeted axillary dissection (TAD), employing marked lymph node biopsy (MLNB) alongside sentinel lymph node biopsy (SLNB), is increasingly recognised for its efficacy in reducing false negative rates (FNRs) in node-positive early breast cancer patients ...
Munaser Alamoodi, Umar Wazir, Janhavi Venkataraman, Reham Almukbel, Kefah Mokbel   +4 more
doaj   +1 more source

Analysis the scatter parameter of SOI RF switch with different design structure

Dianzi Jishu Yingyong, 2019
Based on commercial 0.2 μm SOI RF process platform, the influence of stack, width, bias resistance and bias voltage on scatter parameter characteristics of test structure for SOI RF switch application is investigated, including series branch, shunt ...
Xin Haiwei, Liu Zhangli
doaj   +1 more source

Coping and Self-Medication in a Community Sample of Junior High School Students

Pain Research and Management, 1997
OBJECTIVE: To examine differences between high and low catastrophizers in terms of pain, self-medication, coping, age and sex.
Geneviève Bianca V Bedard, Graham J Reid, Patrick J McGrath, Christine T Chambers   +3 more
doaj   +1 more source

The Role of Inflammasome Activation in Early HIV Infection

Journal of Immunology Research, 2021
The inflammasome pathway is an important arm of the innate immune system that provides antiviral immunity against many viruses. The main pathways involved in virus infections include the NLRP3, IFI16, and AIM2 pathways.
Cyril Jabea Ekabe, Njinju Asaba Clinton, Jules Kehbila, Ngangom Chouamo Franck   +3 more
doaj   +1 more source

Implementing recommendations for routine mismatch repair (MMR) immunohistochemistry (IHC) testing of endometrial cancer and subsequent patient management

BMJ Open Quality
Lynch syndrome is associated with an increased risk of cancer, including endometrial cancer. We audited the introduction of a nurse-led testing and management pathway for Lynch syndrome.
Jo Morrison, Mohamed Shawky, Maria Murrey   +2 more
doaj   +1 more source

Differences in attitudes to feeding post repair of Gastroschisis and development of a standardized feeding protocol

BMC Pediatrics, 2019
Background The purpose of this study was to examine differences in attitudes to feeding in neonates with Gastroschisis between clinical groups and to develop a standardized feeding protocol.
Donna Hobson, Kaye Spence, Amit Trivedi, Gordon Thomas   +3 more
doaj   +1 more source