Results 21 to 30 of about 1,284,966 (332)

Can Lenalidomide Protect against Severe COVID-19 Symptoms in Multiple Myeloma Patients? A Case Series and Review of the Literature

European Journal of Case Reports in Internal Medicine, 2022
We present a case series of three multiple myeloma (MM) patients on lenalidomide for maintenance therapy who were at high risk of coronavirus disease 2019 (COVID-19) complications and mortality.
Ali Al Sbihi, Nouraldeen Manasrah, Dahlia Sano   +2 more
doaj   +1 more source

Preclinical pharmacology and safety studies to support an AAV9 NGLY1 gene therapy clinical trial for the treatment of NGLY1 deficiency

Molecular Therapy: Methods & Clinical Development
GS-100 is an AAV9 gene replacement therapy for the treatment of N-glycanase 1 (NGLY1) deficiency, an ultra-rare, recessive disorder characterized by developmental delay, intellectual disability, hyperkinetic movement disorder, elevated liver enzymes ...
Lei Zhu, Jennifer W. Cook, Alicia Newton, Selina S. Dwight, Brendan Beahm, Matt Wilsey, William F. Mueller, Becky Schweighardt   +7 more
doaj   +1 more source

Giant Amoebic Liver Abscess: A Rare Diagnosis in a Rural Setting of Sub-Saharan Africa

Journal of Parasitology Research, 2021
Background. Extraintestinal amoebiasis is an uncommon complication of Entamoeba histolytica infection, occurring in about 5-10% of patient. Prompt diagnosis and management is essential to prevent complications.
Cyril Jabea Ekabe, Jules Kehbila, Njinju Asaba Clinton   +2 more
doaj   +1 more source

Automatic Computation of Cross Sections in HEP [PDF]

, 2000
For the study of reactions in High Energy Physics (HEP) automatic computation systems have been developed and are widely used nowadays. GRACE is one of such systems and it has achieved much success in analyzing experimental data.
Fujimoto, J., Ishikawa, T., Jimbo, M., Kaneko, T., Kato, K., Kawabata, S., Kon, T., Kurihara, Y., Kuroda, M., Nakazawa, N., Shimizu, Y., Tanaka, H., Yuasa, F.   +12 more
core   +2 more sources

The Healthcare Amyloidosis European Registry (HEAR): design of a national registry with a European extension strategy, and foundation of the F-CRIN GRACE network

Orphanet Journal of Rare Diseases
Background Cardiac amyloidosis (CA) is a rare disease that can lead to poor quality of life, conduction disorders, arrhythmia, heart failure, and even death.
Patricia Réant, Mounira Kharoubi, Erwan Donal, Fabrice Bauer, Mélanie Bézard, Arnaud Bisson, Diane Bodez, Océane Bouchot, Eve Cariou, Phillipe Charron, Jérôme Costa, Pierre-Yves Courand, Charlotte Dagrenat, Francois Delelis, Antoine Jobbe Duval, Jean-Christophe Eicher, Antoine Fraix, Barnabas Gellen, Jean-Pierre Gueffet, Damien Guijarro, Gilbert Habib, Albert Hagège, Olivier Huttin, Arnaud Jaccard, Julien Jeanneteau, Damien Legallois, Damien Logeart, Lise Legrand, Jocelyn Inamo, Léa Marguerit, Raphaël Mirailles, Théo Pezel, Nicolas Piriou, Francois Roubille, Basile Mouhat, Romain Trésorier, Jean-Jacques Von Hunolstein, Charles Taieb, Muriel Salvat, Amira Zaroui, Olivier Lairez, Thibaud Damy   +41 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

GRACE gravity solutions validated by in-situ ocean bottom pressure in different regions of the global ocean [PDF]

, 2009
The GRACE satellite mission provides gravity field estimates of the Earth with unprecedented accuracy. Nevertheless,the realistic detection of oceanic mass redistribution remains challenging due to comparatively small signalamplitude, aliasing by tides ...
Boebel, Olaf, Böning, Carmen, Macrander, Annecke, Schröter, Jens   +3 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Cynthia and Parodies [PDF]

, 2016
Includes: Cynthia , by Grace Ferguson and Parodies , by Gene Smith and Grace ...
Ferguson, Grace, Smith, Gene
core   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source