Results 191 to 200 of about 6,714 (280)

Reducing the replication time for structural estimations: A successful replication of “An Anatomy of International Trade” using GPU computing

open access: yesEconomic Inquiry, Volume 63, Issue 2, Page 424-440, April 2025.
Abstract Eaton, Kortum, and Kramarz (2011) (EKK) discovered empirical patterns from French manufacturing firms that a baseline firm heterogeneity model could not explain. The authors proposed and estimated a model that closely matches the patterns observed in French data.
Jiatong Zhong
wiley   +1 more source

The Appreciation Game. A Monist Ontology of Works of Art

open access: yesEuropean Journal of Philosophy, EarlyView.
Abstract A pluralist ontology of art states that works of art can belong to distinct ontological categories whereas a monist ontology states that all works of art belong to one ontological category. A monist ontology would be preferable since it is more informative about the nature of art, and may pave the way for a definition of art.
Enrico Terrone
wiley   +1 more source

Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors

open access: yesThe FEBS Journal, EarlyView.
NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu   +9 more
wiley   +1 more source

Lock, relax, load, and shoot: a molecular perspective on Nedd4 regulation

open access: yesThe FEBS Journal, EarlyView.
Structural basis of inactive and active states of the Nedd4 HECT E3 ligase subfamily, following a ‘lock, relax, load, and shoot’ mechanism. In the locked, autoinhibited state, intramolecular domain interactions restrain the HECT domain. Relaxation releases these restraints, allowing loading of ubiquitin onto the catalytic cysteine, followed by the ...
Masa Janosev   +2 more
wiley   +1 more source

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