Results 211 to 220 of about 209,934 (245)

A tutorial for understanding SEM using R: Where do all the numbers come from?

open access: yesBritish Journal of Mathematical and Statistical Psychology, EarlyView.
Abstract Structural equation modeling (SEM) is often seen as a complex and difficult method, especially for those who want to understand how the numbers in SEM software output are actually computed. Although many open‐source SEM tools are now available—especially in the R programming environment—looking into their source code to understand the ...
Yves Rosseel, Marc Vidal
wiley   +1 more source

Health Side Story: Scoping Review of Literature on Narrative Therapy for ADHD. [PDF]

open access: yesHealthcare (Basel)
Ophir Y   +3 more
europepmc   +1 more source

To vary or not to vary: A flexible empirical Bayes factor for testing variance components

open access: yesBritish Journal of Mathematical and Statistical Psychology, EarlyView.
Abstract Random effects are the gold standard for capturing structural heterogeneity, such as individual differences or temporal dependence. Yet testing their presence is difficult because variance components are constrained to be non‐negative, creating a boundary problem. This paper introduces a flexible empirical Bayes factor (EBF) for testing random
Fabio Vieira, Hongwei Zhao, Joris Mulder
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown   +2 more
wiley   +1 more source

A covalent peptide engager approach to equip immunotherapeutic monoclonal and pan IgG serum antibodies with new tumour‐targeting function

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Site‐specific antibody modification is a useful chemical strategy to elaborate antibody therapeutic function. Conventional lysine‐ or cysteine‐based conjugation methods generate heterogeneous products, while protein engineering approaches are resource‐intensive.
Karolina Krygier   +2 more
wiley   +1 more source

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