Results 201 to 210 of about 6,739 (277)

The Appreciation Game. A Monist Ontology of Works of Art

European Journal of Philosophy, EarlyView.
Abstract A pluralist ontology of art states that works of art can belong to distinct ontological categories whereas a monist ontology states that all works of art belong to one ontological category. A monist ontology would be preferable since it is more informative about the nature of art, and may pave the way for a definition of art.
Enrico Terrone
wiley   +1 more source

Structured interconnectivity optimizes neural geometry for balancing specificity and generalization in object recognition. [PDF]

Commun Biol
Zhang Y, Liu J, Liu J.
europepmc   +1 more source

The aesthetic sublime of megaproject structures: A framework and a research agenda

European Management Review, EarlyView.
Abstract The physical structures of megaprojects—such as mega‐canals, metros, railway lines, bridges, tunnels, and iconic opera houses—hold a profound capacity to generate aesthetic experiences with enduring societal impact. Yet, research on megaprojects has predominantly focused on functionality and economic rationale with aesthetics being pushed to ...
Federica De Molli, Alfons van Marrewijk, Arne Carlsen   +2 more
wiley   +1 more source

Emotion Recognition of Violin Playing Based on Big Data Analysis Technologies.

J Environ Public Health, 2022
Zou L.
europepmc   +1 more source

Dimerization‐dependent NOTCH receptor transactivation unveils a class of highly selective NOTCH signalling inhibitors

The FEBS Journal, EarlyView.
NOTCH signalling is indispensable for tissue homeostasis and, consequently, corruption of its normal function promotes numerous diseases, including cancer. However, the development of targeted therapies has been hampered by inefficacy and overt toxicity. Here, we show that NOTCH receptor dimerization is necessary for receptor transactivation, which has
Xinxin Liu, Haijiang Wang, Gunja Mishra, Lin‐Ting Wu, Chao Li, Maarten van Dinther, Jin Liu, Manuel A.F.V. Gonçalves, Peter ten Dijke, David A. Baker   +9 more
wiley   +1 more source

Mapping the Global Research on Drug-Drug Interactions: A Multidecadal Evolution Through AI-Driven Terminology Standardization. [PDF]

Bioengineering (Basel)
Radu AF, Radu A, Tit DM, Bungau G, Negru PA.   +4 more
europepmc   +1 more source

Lock, relax, load, and shoot: a molecular perspective on Nedd4 regulation

The FEBS Journal, EarlyView.
Structural basis of inactive and active states of the Nedd4 HECT E3 ligase subfamily, following a ‘lock, relax, load, and shoot’ mechanism. In the locked, autoinhibited state, intramolecular domain interactions restrain the HECT domain. Relaxation releases these restraints, allowing loading of ubiquitin onto the catalytic cysteine, followed by the ...
Masa Janosev, Tomas Obsil, Veronika Obsilova   +2 more
wiley   +1 more source

Financial Statement Information and Equity Value: The Role of Real Options Characteristics

Financial Management, EarlyView.
ABSTRACT This paper examines whether firm‐specific real options characteristics are equity value‐relevant beyond valuation estimates anchored in financial statements. Using extensive historical data for the United Kingdom, we assess and compare the forecast accuracy and explanatory power for stock prices of equity valuation models based on residual ...
Mingyu (Chandler) Chen, Colin Clubb, Tarik Driouchi   +2 more
wiley   +1 more source

Gene Editing for Haemophilia—The Next Frontier

Haemophilia, EarlyView.
ABSTRACT The recently approved haemophilia A and B gene therapies via adeno‐associated virus (AAV) showed a promising therapeutic response after a single injection, but there are still limitations, including the potential loss of transgene expression and restriction in adults.
Mirko Pinotti, Gregory A. Newby, Sundar Selvaraj, Steven W. Pipe   +3 more
wiley   +1 more source