Results 41 to 50 of about 988,074 (296)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

“Osobni dosjei” vile Frangeš i vile Peroš prije i nakon potresa 2020. godine u Zagrebu

Radovi Instituta za Povijest Umjetnosti, 2020
Na primjeru dviju vila građenih početkom 20. stoljeća, vile Frangeš, pojedinačno zaštićenoga kulturnog dobra, i vile Peroš, koja predstavlja ambijentalnu vrijednost Povijesne urbane cjeline Grad Zagreb, autorice iznose problematiku njihove zaštite i ...
Nina Gazivoda, Marijana Sironić
doaj   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

Polazišta održivoga prostornog razvoja grada

Prostor, 2001
Promjene okoliša rezultat su načina na koji živimo i koristimo prostor. Svi korisnici prostora moraju postati svjesni ekološke odgovornosti. Ne možemo očekivati da ćemo sve probleme okoliša moći riješiti tehnologijom.
Srečko Pegan, Tihomir Jukić
doaj  

Divalent ion substitution effect on Yb-site in Kondo insulator YbB12

AIP Advances, 2018
YbB12 has been investigated energetically as a typical Kondo insulator. To study detailed formation mechanism of Kondo energy gap, we have investigated transport and magnetic properties of Yb1-xR3+xB12 (R3+ = non-magnetic trivalent ions).
W. Matsuhra, K. Yokomichi, W. Hirano, S. Kikuchi, N. Uematsu, H. Nakayama, A. Kondo, K. Kindo, F. Iga   +8 more
doaj   +1 more source

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source

Efficient kinetic method for fluid simulation beyond the Navier-Stokes equation [PDF]

, 2006
We present a further theoretical extension to the kinetic theory based formulation of the lattice Boltzmann method of Shan et al (2006). In addition to the higher order projection of the equilibrium distribution function and a sufficiently accurate Gauss-
C. Cercignani, H. Grad, Hudong Chen, I. Ginzburg, Raoyang Zhang, Xiaowen Shan   +5 more
core   +2 more sources

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Grad-CAM++: Improved Visual Explanations for Deep Convolutional Networks

, 2018
Over the last decade, Convolutional Neural Network (CNN) models have been highly successful in solving complex vision problems. However, these deep models are perceived as "black box" methods considering the lack of understanding of their internal ...
Balasubramanian, Vineeth N, Chattopadhyay, Aditya, Howlader, Prantik, Sarkar, Anirban   +3 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source