Results 111 to 120 of about 987,516 (263)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Economía del agua: conceptos y aplicaciones para una mejor gestión [PDF]
, 2014 Destaca la importancia de instrumentos económicos como las tarifas, los pagos por retribuciones por uso, los derechos y las transacciones condicionadas de agua que pueden generar un uso más eficiente, equitativo y sostenible del agua en situaciones ...
Zegarra Méndez, Eduardo +1 more
core
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Human resources management and leadership in surgery [PDF]
, 2021 Grade, Marian, Ghadimi, Michael
core +1 more source
Patient Preference and Adherence, 2021 Isolde Sommer,1 Viktoria Titscher,1 Monika Szelag,1 Gerald Gartlehner1,2 1Department for Evidence-Based Medicine and Evaluation, Danube University Krems, Krems, Austria; 2RTI International, Research Triangle Park, Raleigh, NC, USACorrespondence: Isolde ...
Sommer I +3 more
doaj
Biophysical approaches for studying viral entry
FEBS Letters, EarlyView.Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley +1 more source
The Effect of Grade Retention on High School Completion [PDF]
Low-achieving students in many school districts are retained in a grade in order to allow them to gain the academic or social skills that teachers believe are necessary to succeed academically. This practice is highly controversial, with many researchers
Brian Jacob, Lars Lefgren
core
Una mirada de largo plazo a la economía campesina en los Andes [PDF]
, 2012 El objetivo del estudio es mostrar cómo han evolucionado las economías en Pomacanchi y Yanamarca -denominadas originalmente por Daniel Cotlear como “tradicional” y “moderna”)- en las últimas dos décadas y qué rol ha tenido la política pública, tanto ...
Ponce, Carmen, Escobal, Javier
core
Radiology and Oncology, 2017 Diffusion kurtosis imaging (DKI) allows for assessment of diffusion influenced by microcellular structures. We analyzed DKI in suspected low-grade gliomas prior to histopathological diagnosis.
Delgado Anna F. +10 more
doaj +1 more source
Graded Poisson and graded Dirac structures
Journal of Mathematical PhysicsThere have been several attempts in recent years to extend the notions of symplectic and Poisson structures in order to create a suitable geometrical framework for classical field theories, trying to achieve a success similar to the use of these concepts in Hamiltonian mechanics.
Manuel de León, Rubén Izquierdo-López
openaire +4 more sources