Results 41 to 50 of about 4,434,198 (281)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

New Silica Laser-Optimized Multimode Optical Fibers with Extremely Enlarged 100-μm Core Diameter for Gigabit Onboard and Industrial Networks

Fibers, 2020
We present new type of silica graded index laser-optimized multimode optical fibers (LOMF) with extremely enlarged core diameter up to 100 μm and “typical” “telecommunication” cladding diameter 125 μm. This optical fiber
Vladimir A. Burdin, Michael V. Dashkov, Vladimir V. Demidov, Konstantin V. Dukelskii, Alexander S. Evtushenko, Artem A. Kuznetsov, Alexandra S. Matrosova, Oleg G. Morozov, Egishe V. Ter-Nersesyants, Alexander A. Vasilets, Elena S. Zaitseva, Alexander E. Zhukov, Anton V. Bourdine   +12 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Numerical Analysis of Optical Fiber Refractive Index in the Miniaturized Graded‐Index Fiber Probe

Engineering Reports
We analyze the impact of the refractive index of optical fibers on the focusing properties of a miniaturized graded‐index (GRIN) fiber probe. The ABCD ray transfer matrix and characteristic parameters are employed to characterize the working distance ...
Shubo Bi, Shuaishuai Zhang, Hongying Tang, Zhanyuan Chang, Wenjing Ma, Hairong Zhu   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

High-Power Continuous-Wave Directly-Diode-Pumped Fiber Raman Lasers

Applied Sciences, 2015
We describe novel fiber Raman lasers pumped directly by spectrally combined high power multimode laser diodes at 975 nm and emitting at 1019 nm. With a commercial multimode graded-index fiber, we reached 20 W of laser output power with a record slope ...
Tianfu Yao, Achar V. Harish, Jayanta K. Sahu, Johan Nilsson   +3 more
doaj   +1 more source

Generation of Narrow Modes in Random Raman Fiber Laser Based on Multimode Fiber

Photonics, 2023
We present a new design of a random Raman fiber laser based on a graded-index multimode fiber as the media composing the cavity that allows the generation of narrow spectral lines.
Ilya D. Vatnik, Oleg A. Gorbunov, Dmitry V. Churkin   +2 more
doaj   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

100.4 W All-Fiber Visible Supercontinuum Source Based on Graded-Index Multimode Fiber

IEEE Photonics Journal
An all-fiber high-power visible light super-continuum (SC) source based on graded-index multimode fiber (GRIN MMF) is presented. In the experiment, a picosecond pulse laser with a center wavelength of 1062 nm is amplified by a multimode ytterbium-doped ...
Zhijian Huang, Tingwu Ge, Guanrui Zhao, Chuang Xue, Ruoyu Jia, Yanli Li, Haohao Kong, Chengxin Li, Yixuan Liu, Miaomiao Yang, Qingxuan Li, Wenbin Qin   +11 more
doaj   +1 more source